NAU publications by SHERC
Faculty & staff publications
NAU faculty and staff have the opportunity to publish their findings and knowledge as authors. SHERC has many researchers that have been cited multiple times in major publications for their great work. The Southwest Health Equity Research Collaborative has accumulated all faculty publications into one, easy to navigate database.
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Camplain, Ricky; Baldwin, Julie A; Warren, Meghan; Camplain, Carolyn; Lininger, Monica R; Trotter, Robert T Physical Activity in People Who Are Incarcerated: A Social Justice Issue Journal Article Journal of Physical Activity and Health, 16 (5), pp. 306–307, 2019. @article{Camplain2019b, title = {Physical Activity in People Who Are Incarcerated: A Social Justice Issue}, author = {Ricky Camplain and Julie A Baldwin and Meghan Warren and Carolyn Camplain and Monica R Lininger and Robert T Trotter}, url = {https://doi.org/10.1123/jpah.2019-0055}, doi = {10.1123/jpah.2019-0055}, year = {2019}, date = {2019-05-01}, journal = {Journal of Physical Activity and Health}, volume = {16}, number = {5}, pages = {306–307}, abstract = {Every year, approximately 12 million Americans cycle in and out of jail (ie, short-term facilities that hold individuals awaiting trial and/or sentenced to a term of less than 1 y).1 Although jails allow incarcerated individuals’ recreation time to engage in physical activity,2 it is not clear to what extent these opportunities are utilized. This potential lack of engagement in physical activity is concerning, especially as some of the benefits of physical activity are immediate and may improve the day-to-day life for those who are incarcerated. For example, a single bout of moderate to vigorous physical activity will reduce blood pressure, improve insulin sensitivity, improve sleep and cognition, and reduce symptoms of anxiety symptoms and anger.3 Unfortunately, use of recreation time in the jail setting has not been described previously, thereby precluding an important area for policy intervention.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Every year, approximately 12 million Americans cycle in and out of jail (ie, short-term facilities that hold individuals awaiting trial and/or sentenced to a term of less than 1 y).1 Although jails allow incarcerated individuals’ recreation time to engage in physical activity,2 it is not clear to what extent these opportunities are utilized. This potential lack of engagement in physical activity is concerning, especially as some of the benefits of physical activity are immediate and may improve the day-to-day life for those who are incarcerated. For example, a single bout of moderate to vigorous physical activity will reduce blood pressure, improve insulin sensitivity, improve sleep and cognition, and reduce symptoms of anxiety symptoms and anger.3 Unfortunately, use of recreation time in the jail setting has not been described previously, thereby precluding an important area for policy intervention. |
Mousavi, Sajad; Afghah, Fatemeh Inter-and intra-patient ECG heartbeat classification for arrhythmia detection: a sequence to sequence deep learning approach Journal Article IEEE International Conference on Acoustics, Speech and Signal Processing, pp. 1308-1312, 2019. @article{Mousavi2019b, title = {Inter-and intra-patient ECG heartbeat classification for arrhythmia detection: a sequence to sequence deep learning approach}, author = {Sajad Mousavi and Fatemeh Afghah}, url = {https://ieeexplore.ieee.org/document/8683140}, doi = {10.1109/icassp.2019.8683140}, year = {2019}, date = {2019-04-17}, journal = {IEEE International Conference on Acoustics, Speech and Signal Processing}, pages = {1308-1312}, abstract = {Electrocardiogram (ECG) signal is a common and powerful tool to study heart function and diagnose several abnormal arrhythmias. While there have been remarkable improvements in cardiac arrhythmia classification methods, they still cannot offer acceptable performance in detecting different heart conditions, especially when dealing with imbalanced datasets. In this paper, we propose a solution to address this limitation of current classification approaches by developing an automatic heartbeat classification method using deep convolutional neural networks and sequence to sequence models. We evaluated the proposed method on the MIT-BIH arrhythmia database, considering the intra-patient and inter-patient paradigms, and the AAMI EC57 standard. The evaluation results for both paradigms show that our method achieves the best performance in the literature (a positive predictive value of 96.46% and sensitivity of 100% for the category S, and a positive predictive value of 98.68% and sensitivity of 97.40% for the category F for the intra-patient scheme; a positive predictive value of 92.57% and sensitivity of 88.94% for the category S, and a positive predictive value of 99.50% and sensitivity of 99.94% for the category V for the inter-patient scheme.). The source code is available at https://github.com/SajadMo/ECG-Heartbeat-Classification-seq2seq-model.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Electrocardiogram (ECG) signal is a common and powerful tool to study heart function and diagnose several abnormal arrhythmias. While there have been remarkable improvements in cardiac arrhythmia classification methods, they still cannot offer acceptable performance in detecting different heart conditions, especially when dealing with imbalanced datasets. In this paper, we propose a solution to address this limitation of current classification approaches by developing an automatic heartbeat classification method using deep convolutional neural networks and sequence to sequence models. We evaluated the proposed method on the MIT-BIH arrhythmia database, considering the intra-patient and inter-patient paradigms, and the AAMI EC57 standard. The evaluation results for both paradigms show that our method achieves the best performance in the literature (a positive predictive value of 96.46% and sensitivity of 100% for the category S, and a positive predictive value of 98.68% and sensitivity of 97.40% for the category F for the intra-patient scheme; a positive predictive value of 92.57% and sensitivity of 88.94% for the category S, and a positive predictive value of 99.50% and sensitivity of 99.94% for the category V for the inter-patient scheme.). The source code is available at https://github.com/SajadMo/ECG-Heartbeat-Classification-seq2seq-model. |
Rivera-Hernandez, Maricruz; Rahman, Momotazur; Mukamel, Dana; Mor, Vincent; Trivedi, Amal Quality of Post-Acute Care in Skilled Nursing Facilities That Disproportionately Serve Black and Hispanic Patients Journal Article The Journals of gerontology. Series A, Biological Sciences and Medical Sciences, 74 (5), pp. 689-697, 2019. @article{Rivera-Hernandez2019, title = {Quality of Post-Acute Care in Skilled Nursing Facilities That Disproportionately Serve Black and Hispanic Patients}, author = {Maricruz Rivera-Hernandez and Momotazur Rahman and Dana Mukamel and Vincent Mor and Amal Trivedi}, url = {https://europepmc.org/article/pmc/pmc6477650}, doi = {10.1093/gerona/gly089}, year = {2019}, date = {2019-04-01}, journal = {The Journals of gerontology. Series A, Biological Sciences and Medical Sciences}, volume = {74}, number = {5}, pages = {689-697}, abstract = {Understanding and addressing racial and ethnic disparities in the quality of post-acute care in skilled nursing facilities is an important health policy issue, particularly as the Medicare program initiates value-based payments for these institutions.Our final cohort included 649,187 Medicare beneficiaries in either the fee-for-service or Medicare Advantage programs, who were 65 and older and were admitted to a skilled nursing facility following an acute hospital stay, from 8,375 skilled nursing facilities. We examined the quality of care in skilled nursing facilities that disproportionately serve minority patients compared to non-Hispanic whites. Three measures, all calculated at the level of the facility, were used to assess quality of care in skilled nursing facilities: (a) 30-day rehospitalization rate; (b) successful discharge from the facility to the community; and (c) Medicare five-star quality ratings. We found that African American post-acute patients are highly concentrated in a small number of institutions, with 28% of facilities accounting for 80% of all post-acute admissions for African American patients. Similarly, just 20% of facilities accounted for 80% of all admissions for Hispanics. Skilled nursing facilities with higher fractions of African American patients had worse performance for three publicly reported quality measures: rehospitalization, successful discharge to the community, and the star rating indicator.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Understanding and addressing racial and ethnic disparities in the quality of post-acute care in skilled nursing facilities is an important health policy issue, particularly as the Medicare program initiates value-based payments for these institutions.Our final cohort included 649,187 Medicare beneficiaries in either the fee-for-service or Medicare Advantage programs, who were 65 and older and were admitted to a skilled nursing facility following an acute hospital stay, from 8,375 skilled nursing facilities. We examined the quality of care in skilled nursing facilities that disproportionately serve minority patients compared to non-Hispanic whites. Three measures, all calculated at the level of the facility, were used to assess quality of care in skilled nursing facilities: (a) 30-day rehospitalization rate; (b) successful discharge from the facility to the community; and (c) Medicare five-star quality ratings. We found that African American post-acute patients are highly concentrated in a small number of institutions, with 28% of facilities accounting for 80% of all post-acute admissions for African American patients. Similarly, just 20% of facilities accounted for 80% of all admissions for Hispanics. Skilled nursing facilities with higher fractions of African American patients had worse performance for three publicly reported quality measures: rehospitalization, successful discharge to the community, and the star rating indicator. |
de Heer, Hendrik; Kinslow, Brian; Lane, Taylor; Tuckman, Ron; Warren, Meghan Only 1 in 10 Patients Told to Lose Weight Seek Help From a Health Professional: A Nationally Representative Sample Journal Article American Journal of Health Promotion, 2019. @article{deHeer2019, title = {Only 1 in 10 Patients Told to Lose Weight Seek Help From a Health Professional: A Nationally Representative Sample}, author = {Hendrik de Heer and Brian Kinslow and Taylor Lane and Ron Tuckman and Meghan Warren}, url = {https://journals.sagepub.com/doi/10.1177/0890117119839904}, doi = {10.1177/0890117119839904}, year = {2019}, date = {2019-03-28}, journal = {American Journal of Health Promotion}, abstract = {Receiving weight loss advice from a health-care provider has been associated with more weight loss efforts and greater odds of achieving weight loss. However, whether patients seek help from their provider or other health professional with weight loss after receiving advice from them to lose weight is largely unknown.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Receiving weight loss advice from a health-care provider has been associated with more weight loss efforts and greater odds of achieving weight loss. However, whether patients seek help from their provider or other health professional with weight loss after receiving advice from them to lose weight is largely unknown. |
Parsons, Michelle Anne; Barger, Steven D The US Mortality Crisis: An Examination of Non-Hispanic White Mortality and Morbidity in Yavapai County, Arizona Journal Article Journal of Community Health, 44 , pp. 661-667, 2019. @article{Parsons2019, title = {The US Mortality Crisis: An Examination of Non-Hispanic White Mortality and Morbidity in Yavapai County, Arizona}, author = {Michelle Anne Parsons and Steven D Barger}, url = {https://link.springer.com/article/10.1007/s10900-019-00648-3}, doi = {10.1007/s10900-019-00648-3}, year = {2019}, date = {2019-03-15}, journal = {Journal of Community Health}, volume = {44}, pages = {661-667}, abstract = {Midlife non-Hispanic white mortality in the United States is rising, particularly in small metro and rural counties. This article responds to calls for county-level studies. We examine social determinants of morbidity and mortality among adult non-Hispanic whites in Yavapai County, Arizona, as part of an integrative study. We report overall mortality trends in Yavapai County using CDC Wonder data and then examine social determinants of reported physical health and mental distress in Yavapai County data using 6 years (2011-2016) of the Arizona Behavioral Risk Factor Surveillance System (BRFSS). The BRFSS includes 1,024 non-Hispanic white respondents aged 25-64. We also present data from the recently established Yavapai County Overdose Fatality Review Board (YCOFRB). Mortality trends indicate that suicide and drug and alcohol-related mortality have all increased since 1999. These increases affect all 5-year age groups from 25 to 64 and both men and women. BRFSS data show that low education and unemployment, but not number of children or home ownership, are significantly associated with worse reported health and frequent mental distress in multivariate analyses. The YCOFRB point to the importance of homelessness and mental health. The mortality crisis in Yavapai County is not restricted to midlife or to drug-related deaths. The unemployed and those with low levels of education are particularly at risk. There is a need for integrative approaches that use local data to elucidate social determinants of morbidity and mortality and to reveal structural determinants.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Midlife non-Hispanic white mortality in the United States is rising, particularly in small metro and rural counties. This article responds to calls for county-level studies. We examine social determinants of morbidity and mortality among adult non-Hispanic whites in Yavapai County, Arizona, as part of an integrative study. We report overall mortality trends in Yavapai County using CDC Wonder data and then examine social determinants of reported physical health and mental distress in Yavapai County data using 6 years (2011-2016) of the Arizona Behavioral Risk Factor Surveillance System (BRFSS). The BRFSS includes 1,024 non-Hispanic white respondents aged 25-64. We also present data from the recently established Yavapai County Overdose Fatality Review Board (YCOFRB). Mortality trends indicate that suicide and drug and alcohol-related mortality have all increased since 1999. These increases affect all 5-year age groups from 25 to 64 and both men and women. BRFSS data show that low education and unemployment, but not number of children or home ownership, are significantly associated with worse reported health and frequent mental distress in multivariate analyses. The YCOFRB point to the importance of homelessness and mental health. The mortality crisis in Yavapai County is not restricted to midlife or to drug-related deaths. The unemployed and those with low levels of education are particularly at risk. There is a need for integrative approaches that use local data to elucidate social determinants of morbidity and mortality and to reveal structural determinants. |
Ofili, Elizabeth O; Tchounwou, Paul B; Fernandez-Repollet, Emma; Yanagihara, Richard; Akintobi, Tabia H; Lee, Jae E; Malouhi, Mohamad; Jr, Solomon Garner T; Hayes, Traci T; Baker, Almelida R; 2nd, Andrew Dent L; Abdelrahim, Muna; Rollins, Latrice; Chang, Sandra P; Sy, Angela; Hernandez, Brenda Y; Bullard, Pamela L; Jr, Richard Noel J; Shiramizu, Bruce; Hedges, Jerris R; Berry, Marla J; Bond, Vincent C; Lima, Maria F; Mokuau, Noreen; Kirken, Robert A; Cruz-Correa, Marcia; Sarpong, Daniel F; Vadgama, Jaydutt; Yates, Clayton; Kahn, Shafiq A; Soliman, Karam F; Perry, George; Pezzano, Mark; Luciano, Carlos A; Barnett, Edwina M; Oyekan, Adebayo; Kumar, Deepak; Norris, Keith C Ethnicity and Disease, 29 (1), 2019. @article{Ofili2019, title = {The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research}, author = {Elizabeth O Ofili and Paul B Tchounwou and Emma Fernandez-Repollet and Richard Yanagihara and Tabia H Akintobi and Jae E Lee and Mohamad Malouhi and Solomon T Garner Jr and Traci T Hayes and Almelida R Baker and Andrew L Dent 2nd and Muna Abdelrahim and Latrice Rollins and Sandra P Chang and Angela Sy and Brenda Y Hernandez and Pamela L Bullard and Richard J Noel Jr and Bruce Shiramizu and Jerris R Hedges and Marla J Berry and Vincent C Bond and Maria F Lima and Noreen Mokuau and Robert A Kirken and Marcia Cruz-Correa and Daniel F Sarpong and Jaydutt Vadgama and Clayton Yates and Shafiq A Kahn and Karam F Soliman and George Perry and Mark Pezzano and Carlos A Luciano and M Edwina Barnett and Adebayo Oyekan and Deepak Kumar and Keith C Norris}, url = {https://www.ethndis.org/edonline/index.php/ethndis/article/view/1066}, doi = {10.18865/ed.29.S1.135}, year = {2019}, date = {2019-02-21}, journal = {Ethnicity and Disease}, volume = {29}, number = {1}, abstract = {The Research Centers in Minority Institutions (RCMI) program was established by the US Congress to support the development of biomedical research infrastructure at minority-serving institutions granting doctoral degrees in the health professions or in a health-related science. RCMI institutions also conduct research on diseases that disproportionately affect racial and ethnic minorities (ie, African Americans/Blacks, American Indians and Alaska Natives, Hispanics, Native Hawaiians and Other Pacific Islanders), those of low socioeconomic status, and rural persons. Quantitative metrics, including the numbers of doctoral science degrees granted to underrepresented students, NIH peer-reviewed research funding, peer-reviewed publications, and numbers of racial and ethnic minorities participating in sponsored research, demonstrate that RCMI grantee institutions have made substantial progress toward the intent of the Congressional legislation, as well as the NIH/NIMHD-linked goals of addressing workforce diversity and health disparities. Despite this progress, nationally, many challenges remain, including persistent disparities in research and career development awards to minority investigators. The continuing underrepresentation of minority investigators in NIH-sponsored research across multiple disease areas is of concern, in the face of unrelenting national health inequities. With the collaborative network support by the RCMI Translational Research Network (RTRN), the RCMI community is uniquely positioned to address these challenges through its community engagement and strategic partnerships with non-RCMI institutions. Funding agencies can play an important role by incentivizing such collaborations, and incorporating metrics for research funding that address underrepresented populations, workforce diversity and health equity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Research Centers in Minority Institutions (RCMI) program was established by the US Congress to support the development of biomedical research infrastructure at minority-serving institutions granting doctoral degrees in the health professions or in a health-related science. RCMI institutions also conduct research on diseases that disproportionately affect racial and ethnic minorities (ie, African Americans/Blacks, American Indians and Alaska Natives, Hispanics, Native Hawaiians and Other Pacific Islanders), those of low socioeconomic status, and rural persons. Quantitative metrics, including the numbers of doctoral science degrees granted to underrepresented students, NIH peer-reviewed research funding, peer-reviewed publications, and numbers of racial and ethnic minorities participating in sponsored research, demonstrate that RCMI grantee institutions have made substantial progress toward the intent of the Congressional legislation, as well as the NIH/NIMHD-linked goals of addressing workforce diversity and health disparities. Despite this progress, nationally, many challenges remain, including persistent disparities in research and career development awards to minority investigators. The continuing underrepresentation of minority investigators in NIH-sponsored research across multiple disease areas is of concern, in the face of unrelenting national health inequities. With the collaborative network support by the RCMI Translational Research Network (RTRN), the RCMI community is uniquely positioned to address these challenges through its community engagement and strategic partnerships with non-RCMI institutions. Funding agencies can play an important role by incentivizing such collaborations, and incorporating metrics for research funding that address underrepresented populations, workforce diversity and health equity. |
Teufel-Shone, Nicolette I; Schwartz, Anna L; Hardy, Lisa J; de Heer, Hendrik D; Williamson, Heather J; Dunn, Dorothy J; Polingyumptewa, Kellen; Chief, Carmenlita Supporting New Community-Based Participatory Research Partnerships Journal Article International Journal of Environmental Research and Public Health, 16 (1), 2018. @article{Teufel-Shone2018, title = {Supporting New Community-Based Participatory Research Partnerships}, author = {Nicolette I Teufel-Shone and Anna L Schwartz and Lisa J Hardy and Hendrik D de Heer and Heather J Williamson and Dorothy J Dunn and Kellen Polingyumptewa and Carmenlita Chief}, url = {https://doi.org/10.3390/ijerph16010044}, doi = {10.3390/ijerph16010044}, year = {2018}, date = {2018-12-25}, journal = {International Journal of Environmental Research and Public Health}, volume = {16}, number = {1}, abstract = {Marginalized communities have a documented distrust of research grounded in negative portrayals in the academic literature. Yet, trusted partnerships, the foundation for Community-Based Participatory Research (CBPR), require time to build the capacity for joint decision-making, equitable involvement of academically trained and community investigators, and co-learning. Trust can be difficult to develop within the short time between a funding opportunity announcement and application submission. Resources to support community- and academic-based investigators' time to discuss contexts, concerns, integration of expertise and locally acceptable research designs and data collection are limited. The National Institutes of Health (NIH) funded Center for American Indian Resilience and the Southwest Health Equity Research Collaborative have implemented an internal funding mechanism to support community and academic-based investigators' travel cost and time to discuss complementary areas of interest and skills and to decide if moving forward with a partnership and a collaborative grant proposal would be beneficial to the community. The rationale and administration of this Community-Campus Partnership Support (CCPS) Program are described and four examples of supported efforts are provided. Centers and training programs frequently fund pilot grants to support junior investigators and/or exploratory research. This CCPS mechanism should be considered as precursor to pilot work, to stimulate partnership building without the pressure of an approaching grant application deadline. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Marginalized communities have a documented distrust of research grounded in negative portrayals in the academic literature. Yet, trusted partnerships, the foundation for Community-Based Participatory Research (CBPR), require time to build the capacity for joint decision-making, equitable involvement of academically trained and community investigators, and co-learning. Trust can be difficult to develop within the short time between a funding opportunity announcement and application submission. Resources to support community- and academic-based investigators' time to discuss contexts, concerns, integration of expertise and locally acceptable research designs and data collection are limited. The National Institutes of Health (NIH) funded Center for American Indian Resilience and the Southwest Health Equity Research Collaborative have implemented an internal funding mechanism to support community and academic-based investigators' travel cost and time to discuss complementary areas of interest and skills and to decide if moving forward with a partnership and a collaborative grant proposal would be beneficial to the community. The rationale and administration of this Community-Campus Partnership Support (CCPS) Program are described and four examples of supported efforts are provided. Centers and training programs frequently fund pilot grants to support junior investigators and/or exploratory research. This CCPS mechanism should be considered as precursor to pilot work, to stimulate partnership building without the pressure of an approaching grant application deadline. |
Trotter, Robert T; Lininger, Monica R; Camplain, Ricky; Fofanov, Viacheslav Y; Camplain, Carolyn; Baldwin, Julie A International Journal of Environmental Research and Public Health, 15 (11), 2018. @article{Trotter2018, title = {A Survey of Health Disparities, Social Determinants of Health, and Converging Morbidities in a County Jail: A Cultural-Ecological Assessment of Health Conditions in Jail Populations}, author = {Robert T Trotter and Monica R Lininger and Ricky Camplain and Viacheslav Y Fofanov and Carolyn Camplain and Julie A Baldwin}, url = {https://doi.org/10.3390/ijerph15112500}, doi = {10.3390/ijerph15112500}, year = {2018}, date = {2018-11-08}, journal = {International Journal of Environmental Research and Public Health}, volume = {15}, number = {11}, abstract = {The environmental health status of jail populations in the United States constitutes a significant public health threat for prisoners and the general population. The ecology of jails creates a dynamic condition in relation to general population health due to the concentrated potential exposure to infectious diseases, difficult access to treatment for chronic health conditions, interruption in continuity of care for serious behavioral health conditions, as well as on-going issues for the prevention and treatment of substance abuse disorders. This paper reports on elements of a cross-sectional survey embedded in a parent project, "Health Disparities in Jail Populations." The overall project includes a comprehensive secondary data analysis of the health status of county jail populations, along with primary data collection that includes a cross-sectional health and health care services survey of incarcerated individuals, coupled with collection of biological samples to investigate infectious disease characteristics of a county jail population. This paper reports on the primary results of the survey data collection that indicate that this is a population with complex and interacting co-morbidities, as well as significant health disparities compared to the general population.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The environmental health status of jail populations in the United States constitutes a significant public health threat for prisoners and the general population. The ecology of jails creates a dynamic condition in relation to general population health due to the concentrated potential exposure to infectious diseases, difficult access to treatment for chronic health conditions, interruption in continuity of care for serious behavioral health conditions, as well as on-going issues for the prevention and treatment of substance abuse disorders. This paper reports on elements of a cross-sectional survey embedded in a parent project, "Health Disparities in Jail Populations." The overall project includes a comprehensive secondary data analysis of the health status of county jail populations, along with primary data collection that includes a cross-sectional health and health care services survey of incarcerated individuals, coupled with collection of biological samples to investigate infectious disease characteristics of a county jail population. This paper reports on the primary results of the survey data collection that indicate that this is a population with complex and interacting co-morbidities, as well as significant health disparities compared to the general population. |
Trotter, Robert T; Camplain, Ricky; Eaves, Emery R; Fofanov, Viacheslav Y; Dmitrieva, Natalia O; Hepp1, Crystal M; Warren, Meghan; Barrios, Brianna A; Pagel, Nicole; Mayer, Alyssa; Baldwin, Julie A Health Disparities and Converging Epidemics in Jail Populations: Protocol for a Mixed-Methods Study Journal Article JMIR Research Protocols, 7 (10), 2018. @article{Trotter24.1, title = {Health Disparities and Converging Epidemics in Jail Populations: Protocol for a Mixed-Methods Study}, author = {Robert T Trotter and Ricky Camplain and Emery R Eaves and Viacheslav Y Fofanov and Natalia O Dmitrieva and Crystal M Hepp1 and Meghan Warren and Brianna A Barrios and Nicole Pagel and Alyssa Mayer and Julie A Baldwin}, doi = {10.2196/10337}, year = {2018}, date = {2018-10-24}, journal = {JMIR Research Protocols}, volume = {7}, number = {10}, abstract = {Incarcerated populations have increased in the last 20 years and >12 million individuals cycle in and out of jails each year. Previous research has predominately focused on the prison population. However, a substantial gap exists in understanding the health, well-being, and health care utilization patterns in jail populations. This pilot study has 5 main objectives: (1) define recidivists of the jail system, individuals characterized by high incarceration rates; (2) describe and compare the demographic and clinical characteristics of incarcerated individuals; (3) identify jail-associated health disparities; (4) estimate associations between incarceration and health; and (5) describe model patterns in health care and jail utilization. To date, we have permission to link data across acquired databases. We have initiated data transfer, protection, and initial assessment of the 6 secondary databases. Of 199 inmates consented and enrolled, we have permission from 97.0% (193/199) to access and link electronic medical and incarceration records to their survey responses, and 95.0% (189/199) of interviewed inmates have given nasal and buccal swabs for analysis of S. aureus and the dental microbiome.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Incarcerated populations have increased in the last 20 years and >12 million individuals cycle in and out of jails each year. Previous research has predominately focused on the prison population. However, a substantial gap exists in understanding the health, well-being, and health care utilization patterns in jail populations. This pilot study has 5 main objectives: (1) define recidivists of the jail system, individuals characterized by high incarceration rates; (2) describe and compare the demographic and clinical characteristics of incarcerated individuals; (3) identify jail-associated health disparities; (4) estimate associations between incarceration and health; and (5) describe model patterns in health care and jail utilization. To date, we have permission to link data across acquired databases. We have initiated data transfer, protection, and initial assessment of the 6 secondary databases. Of 199 inmates consented and enrolled, we have permission from 97.0% (193/199) to access and link electronic medical and incarceration records to their survey responses, and 95.0% (189/199) of interviewed inmates have given nasal and buccal swabs for analysis of S. aureus and the dental microbiome. |
Varadaraj, Archana; Magdaleno, Carina; Mythreye, Karthikeyan Deoxycholate Fractionation of Fibronectin (FN) and Biotinylation Assay to Measure Recycled FN Fibrils in Epithelial Cells Journal Article Bio-protocol, 8 (16), 2018. @article{Varadaraj2018, title = {Deoxycholate Fractionation of Fibronectin (FN) and Biotinylation Assay to Measure Recycled FN Fibrils in Epithelial Cells}, author = {Archana Varadaraj and Carina Magdaleno and Karthikeyan Mythreye}, url = {https://bio-protocol.org/e2972}, doi = {10.21769/BioProtoc.2972}, year = {2018}, date = {2018-08-20}, journal = {Bio-protocol}, volume = {8}, number = {16}, abstract = {Fibronectin (FN) is an extracellular matrix protein that is secreted by many cell types and binds predominantly to the cell surface receptor Integrin α5β1. Integrin α5β1 binding initiates the step-wise assembly of FN into fibrils, a process called fibrillogenesis. We and several others have demonstrated critical effects of fibrillogenesis on cell migration and metastasis. While immunostaining and microscopy methods help visualize FN incorporation into fibrils, with each fibril being at least 3 μm in length, the first study that developed a method to biochemically fractionate FN to quantify fibril incorporated FN was published by Jean Schwarzbauer's group in 1996. Our protocol was adapted from the original publication, and has been tested on multiple cell types including as shown here in MCF10A mammary epithelial and Caki-1 renal cancer epithelial cells. Using two detergent extractions, cellular FN is separated into detergent insoluble or fibril incorporated FN and soluble FN or unincorporated fractions. To determine whether fibrillogenesis utilizes a recycled pool of FN, we have used a Biotin labeled FN (FN-Biotin) recycling assay, that has been modified from a previous study. Using a combination of the recycling assay and deoxycholate fractionation methods, one can quantitatively demonstrate the extent of fibrillogenesis in cells under different experimental conditions and determine the source of FN for fibrillogenesis.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Fibronectin (FN) is an extracellular matrix protein that is secreted by many cell types and binds predominantly to the cell surface receptor Integrin α5β1. Integrin α5β1 binding initiates the step-wise assembly of FN into fibrils, a process called fibrillogenesis. We and several others have demonstrated critical effects of fibrillogenesis on cell migration and metastasis. While immunostaining and microscopy methods help visualize FN incorporation into fibrils, with each fibril being at least 3 μm in length, the first study that developed a method to biochemically fractionate FN to quantify fibril incorporated FN was published by Jean Schwarzbauer's group in 1996. Our protocol was adapted from the original publication, and has been tested on multiple cell types including as shown here in MCF10A mammary epithelial and Caki-1 renal cancer epithelial cells. Using two detergent extractions, cellular FN is separated into detergent insoluble or fibril incorporated FN and soluble FN or unincorporated fractions. To determine whether fibrillogenesis utilizes a recycled pool of FN, we have used a Biotin labeled FN (FN-Biotin) recycling assay, that has been modified from a previous study. Using a combination of the recycling assay and deoxycholate fractionation methods, one can quantitatively demonstrate the extent of fibrillogenesis in cells under different experimental conditions and determine the source of FN for fibrillogenesis. |
Pinto, Bronson I; Lujan, Oscar R; Ramos, Stephan A; Propper, Catherine R; Kellar, Robert S Estrogen Mitigates the Negative Effects of Arsenic Contamination in an In Vitro Wound Model Journal Article Applied In Vitro Toxicology, 4 (1), 2018. @article{Pinto2018, title = {Estrogen Mitigates the Negative Effects of Arsenic Contamination in an In Vitro Wound Model}, author = {Bronson I Pinto and Oscar R Lujan and Stephan A Ramos and Catherine R Propper and Robert S Kellar}, url = {https://www.liebertpub.com/doi/10.1089/aivt.2017.0020}, doi = {10.1089/aivt.2017.0020}, year = {2018}, date = {2018-03-01}, journal = {Applied In Vitro Toxicology}, volume = {4}, number = {1}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
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