NAU publications by SHERC
Faculty & staff publications
NAU faculty and staff have the opportunity to publish their findings and knowledge as authors. SHERC has many researchers that have been cited multiple times in major publications for their great work. The Southwest Health Equity Research Collaborative has accumulated all faculty publications into one, easy to navigate database.
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Remiker, Mark; Sabo, Samantha; Jiménez, Dulce; Longorio, Alexandra Samarron; Chief, Carmenlita; Williamson, Heather; Teufel-Shone, Nicolette Using a Multisectoral Approach to Advance Health Equity in Rural Arizona: Community-Engaged Survey Development and Implementation Study Journal Article JMIR Formative Research, 5 (5), 2021. @article{Remiker2021, title = {Using a Multisectoral Approach to Advance Health Equity in Rural Arizona: Community-Engaged Survey Development and Implementation Study}, author = {Mark Remiker and Samantha Sabo and Dulce Jiménez and Alexandra Samarron Longorio and Carmenlita Chief and Heather Williamson and Nicolette Teufel-Shone }, url = {https://formative.jmir.org/2021/5/e25577}, doi = {10.2196/25577}, year = {2021}, date = {2021-12-05}, journal = {JMIR Formative Research}, volume = {5}, number = {5}, abstract = {Over the past decade, public health research and practice sectors have shifted their focus away from identifying health disparities and toward addressing the social, environmental, and economic determinants of health equity. Given the complex and interrelated nature of these determinants, developing policies that will advance health equity requires collaboration across sectors outside of health. However, engaging various stakeholder groups, tapping into their unique knowledge systems, and identifying common objectives across sectors is difficult and time consuming and can impede collaborative efforts.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Over the past decade, public health research and practice sectors have shifted their focus away from identifying health disparities and toward addressing the social, environmental, and economic determinants of health equity. Given the complex and interrelated nature of these determinants, developing policies that will advance health equity requires collaboration across sectors outside of health. However, engaging various stakeholder groups, tapping into their unique knowledge systems, and identifying common objectives across sectors is difficult and time consuming and can impede collaborative efforts. |
Baldwin, Julie A; II, Robert Trotter T; Remiker, Mark; Buck, Loren C; Aguirre, Amanda; Milner, Trudie; Torres, Emma; von Hippel, Frank A A Community-Engaged Approach to Environmental Health Research: Process and Lessons Learned Journal Article Muse, 15 (4), pp. 533-540, 2021. @article{Baldwin2021, title = {A Community-Engaged Approach to Environmental Health Research: Process and Lessons Learned}, author = {Julie A. Baldwin and Robert T. Trotter II and Mark Remiker and C. Loren Buck and Amanda Aguirre and Trudie Milner and Emma Torres and Frank A. von Hippel}, url = {https://muse.jhu.edu/article/842128}, doi = {10.1353/cpr.2021.0043}, year = {2021}, date = {2021-12-01}, journal = {Muse}, volume = {15}, number = {4}, pages = {533-540}, abstract = {Background: This study used a community-engaged approach to examine associations between environmental contaminants and health outcomes among residents of Yuma, Arizona. Our team conducted a process evaluation to assess scientific rigor and adherence to community engagement principles. Objective: Our evaluation focused on four dimensions of community-based participatory research: 1) context, 2) group dynamics, 3) intervention and research, and 4) outcomes. Methods: Interviews were conducted with key informants from community partner organizations. Thematic analysis was used to evaluate community partners' experiences with our collaborative process. Lessons Learned: Community partners reported collaborating to establish research goals, recruit participants, collect data, plan analyses, and formulate dissemination strategies. Training needs, roles, and expectations of community partners varied based on available resources, prior research experience, and perceived research challenges. Conclusions: Leveraging community-engaged principles for studies of environmental contamination can expedite recruitment efforts and stimulate action to improve health outcomes.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: This study used a community-engaged approach to examine associations between environmental contaminants and health outcomes among residents of Yuma, Arizona. Our team conducted a process evaluation to assess scientific rigor and adherence to community engagement principles. Objective: Our evaluation focused on four dimensions of community-based participatory research: 1) context, 2) group dynamics, 3) intervention and research, and 4) outcomes. Methods: Interviews were conducted with key informants from community partner organizations. Thematic analysis was used to evaluate community partners' experiences with our collaborative process. Lessons Learned: Community partners reported collaborating to establish research goals, recruit participants, collect data, plan analyses, and formulate dissemination strategies. Training needs, roles, and expectations of community partners varied based on available resources, prior research experience, and perceived research challenges. Conclusions: Leveraging community-engaged principles for studies of environmental contamination can expedite recruitment efforts and stimulate action to improve health outcomes. |
Lee, Michele S; Peart, Jillian R; Armin, Julie S; Williamson, Heather J Journal of Health Disparities Research and Practice, 14 (3), pp. 2, 2021, ISSN: 2166-5222. @article{Lee2021, title = {A Scoping Review of Barriers and Facilitators to Pap Testing in Women with Disabilities and Serious Mental Illnesses: Thirty Years After the Americans with Disabilities Act}, author = {Michele S. Lee and Jillian R. Peart and Julie S. Armin and Heather J. Williamson}, url = {https://digitalscholarship.unlv.edu/jhdrp/vol14/iss3/2}, issn = {2166-5222}, year = {2021}, date = {2021-11-15}, journal = {Journal of Health Disparities Research and Practice}, volume = {14}, number = {3}, pages = {2}, abstract = {Thirty years after the Americans with Disabilities Act (ADA) was passed, promising equal access to health services for people with disabilities and serious mental illness, research on Pap testing continues to uncover health disparities among women with disabilities and women with serious mental illnesses, including those that identify as an ethnic/racial minority.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Thirty years after the Americans with Disabilities Act (ADA) was passed, promising equal access to health services for people with disabilities and serious mental illness, research on Pap testing continues to uncover health disparities among women with disabilities and women with serious mental illnesses, including those that identify as an ethnic/racial minority. |
Kumar, Amit; Roy, Indrakshi; Bosch, Pamela; Fehnel, Corey; Garnica, Nicholas; Cook, Jon; Warren, Meghan; Karmarkar, Amol Medicare Claim–Based National Institutes of Health Stroke Scale to Predict 30-Day Mortality and Hospital Readmission Journal Article Journal of General Internal Medicine, 2021. @article{Kumar2021, title = {Medicare Claim–Based National Institutes of Health Stroke Scale to Predict 30-Day Mortality and Hospital Readmission}, author = {Amit Kumar and Indrakshi Roy and Pamela Bosch and Corey Fehnel and Nicholas Garnica and Jon Cook and Meghan Warren and Amol Karmarkar}, url = {https://doi.org/10.1007/s11606-021-07162-0}, doi = {10.1007/s11606-021-07162-0}, year = {2021}, date = {2021-10-26}, journal = {Journal of General Internal Medicine}, abstract = {The Centers for Medicare and Medicaid Services (CMS) penalizes hospitals for higher than expected 30-day mortality rates using methods without accounting for condition severity risk adjustment. For patients with stroke, CMS claims did not quantify stroke severity until recently, when the National Institutes of Health Stroke Scale (NIHSS) reporting began. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Centers for Medicare and Medicaid Services (CMS) penalizes hospitals for higher than expected 30-day mortality rates using methods without accounting for condition severity risk adjustment. For patients with stroke, CMS claims did not quantify stroke severity until recently, when the National Institutes of Health Stroke Scale (NIHSS) reporting began. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. |
Rivera-Hernandez, Maricruz; Kumar, Amit; Roy, Indrakshi; Fashaw-Walters, Shekinah; Baldwin, Julie A Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer’s Disease and Related Dementias Journal Article Journal of Aging and Health, 2021. @article{Rivera-Hernandez2021, title = {Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer’s Disease and Related Dementias}, author = {Maricruz Rivera-Hernandez and Amit Kumar and Indrakshi Roy and Shekinah Fashaw-Walters and Julie A. Baldwin}, url = {https://doi.org/10.1177/08982643211043319}, doi = {10.1177/08982643211043319}, year = {2021}, date = {2021-10-11}, journal = {Journal of Aging and Health}, abstract = {This article assessed whether disparities among ADRD Medicare beneficiaries existed in five different long-stay quality measures. Methods: We linked individual-level data and facility-level characteristics. The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) received an antipsychotic medication; 3) experienced one/more falls with major injury; 4) were physically restrained; and 5) lost too much weight. Results: In 2016, there were 1,005,781 Medicare Advantage and fee-for-service long-term residents. About 78% were White, 13% Black, 2% Asian/Pacific Islander (Asian/PI), 6% Hispanic, and 0.4% American Indian/Alaska Native (AI/AN). Whites reported higher use of antipsychotic medications along with Hispanics and AI/AN (28%, 28%, and 27%, respectively). Similarly, Whites and AIs/ANs reported having one/more falls compared to the other groups (9% and 8%, respectively). Discussion: Efforts to understand disparities in access and quality of care among American Indians/Alaska Natives are needed, especially post-pandemic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This article assessed whether disparities among ADRD Medicare beneficiaries existed in five different long-stay quality measures. Methods: We linked individual-level data and facility-level characteristics. The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) received an antipsychotic medication; 3) experienced one/more falls with major injury; 4) were physically restrained; and 5) lost too much weight. Results: In 2016, there were 1,005,781 Medicare Advantage and fee-for-service long-term residents. About 78% were White, 13% Black, 2% Asian/Pacific Islander (Asian/PI), 6% Hispanic, and 0.4% American Indian/Alaska Native (AI/AN). Whites reported higher use of antipsychotic medications along with Hispanics and AI/AN (28%, 28%, and 27%, respectively). Similarly, Whites and AIs/ANs reported having one/more falls compared to the other groups (9% and 8%, respectively). Discussion: Efforts to understand disparities in access and quality of care among American Indians/Alaska Natives are needed, especially post-pandemic. |
Pollitt, Amanda M; Roberts, Tangela S Internalized Binegativity, LGBQ + Community Involvement, and Definitions of Bisexuality Journal Article Journal of Bisexuality, 21 (3), pp. 357-379, 2021. @article{Pollitt2021, title = {Internalized Binegativity, LGBQ + Community Involvement, and Definitions of Bisexuality}, author = {Amanda M. Pollitt and Tangela S. Roberts}, url = {https://doi.org/10.1080/15299716.2021.1984363}, doi = {10.1080/15299716.2021.1984363}, year = {2021}, date = {2021-10-06}, journal = {Journal of Bisexuality}, volume = {21}, number = {3}, pages = {357-379}, abstract = {Bisexual people can internalize stigma from both heterosexual and gay/lesbian communities, which often occurs in the form of monosexism, the belief that people should only be attracted to one gender. Although community involvement is protective for lesbian, gay, bisexual, and queer+ (LGBQ+) people, bisexual people may benefit more from bisexual-specific communities than LGBQ + communities because of monosexism. Further, how bisexual people define their identity may be related to internalized binegativity, especially given the historical invisibility of bisexuality in mainstream media and recent debates about the definition of bisexuality within LGBQ + communities. We examined LGBQ + and bisexual-specific community involvement, definitions of bisexuality, and internalized binegativity among an online sample of 816 bisexual adults. Multivariate regression analyses showed that those with spectrum definitions, which acknowledged a nuanced understanding of sex, gender, and sexuality, reported lower internalized binegativity than those with binary definitions, which described sexuality as consistent with mainstream norms. Involvement in LGBQ + communities, but not bisexual communities, was associated with lower internalized binegativity. There was no interaction between type of definition and type of community involvement. Our results suggest that broad community involvement may be protective for internalized binegativity, but findings should be considered in light of a lack of well-funded, local bisexual communities. The current study adds to a growing literature on sexual minority stressors among bisexual people, a population that continues to be understudied.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Bisexual people can internalize stigma from both heterosexual and gay/lesbian communities, which often occurs in the form of monosexism, the belief that people should only be attracted to one gender. Although community involvement is protective for lesbian, gay, bisexual, and queer+ (LGBQ+) people, bisexual people may benefit more from bisexual-specific communities than LGBQ + communities because of monosexism. Further, how bisexual people define their identity may be related to internalized binegativity, especially given the historical invisibility of bisexuality in mainstream media and recent debates about the definition of bisexuality within LGBQ + communities. We examined LGBQ + and bisexual-specific community involvement, definitions of bisexuality, and internalized binegativity among an online sample of 816 bisexual adults. Multivariate regression analyses showed that those with spectrum definitions, which acknowledged a nuanced understanding of sex, gender, and sexuality, reported lower internalized binegativity than those with binary definitions, which described sexuality as consistent with mainstream norms. Involvement in LGBQ + communities, but not bisexual communities, was associated with lower internalized binegativity. There was no interaction between type of definition and type of community involvement. Our results suggest that broad community involvement may be protective for internalized binegativity, but findings should be considered in light of a lack of well-funded, local bisexual communities. The current study adds to a growing literature on sexual minority stressors among bisexual people, a population that continues to be understudied. |
Bordeaux, Skyler J; Baca, Anthony W; Begay, Rene L; Gachupin, Francine C; Caporaso, Gregory J; Herbst-Kralovetz, Melissa M; Lee, Naomi R Designing Inclusive HPV Cancer Vaccines and Increasing Uptake among Native Americans-A Cultural Perspective Review Journal Article Current Oncology, 28 (5), pp. 3705-3716, 2021. @article{Bordeaux2021, title = {Designing Inclusive HPV Cancer Vaccines and Increasing Uptake among Native Americans-A Cultural Perspective Review}, author = {Skyler J Bordeaux and Anthony W Baca and Rene L Begay and Francine C Gachupin and J Gregory Caporaso and Melissa M Herbst-Kralovetz and Naomi R Lee}, url = {https://www.mdpi.com/1718-7729/28/5/316}, doi = {10.3390/curroncol28050316}, year = {2021}, date = {2021-09-24}, journal = {Current Oncology}, volume = {28}, number = {5}, pages = {3705-3716}, abstract = {Despite a global and nationwide decrease, Native Americans continue to experience high rates of cancer morbidity and mortality. Vaccination is one approach to decrease cancer incidence such as the case of cervical cancer. However, the availability of vaccines does not guarantee uptake, as evident in the Coronavirus 2019 pandemic. Therefore, as we consider current and future cancer vaccines, there are certain considerations to be mindful of to increase uptake among Native Americans such as the incidence of disease, social determinants of health, vaccine hesitancy, and historical exclusion in clinical trials. This paper primarily focuses on human papillomavirus (HPV) and potential vaccines for Native Americans. However, we also aim to inform researchers on factors that influence Native American choices surrounding vaccination and interventions including cancer therapies. We begin by providing an overview of the historical distrust and trauma Native Americans experience, both past and present. In addition, we offer guidance and considerations when engaging with sovereign Tribal Nations in vaccine development and clinical trials in order to increase trust and encourage vaccine uptake.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Despite a global and nationwide decrease, Native Americans continue to experience high rates of cancer morbidity and mortality. Vaccination is one approach to decrease cancer incidence such as the case of cervical cancer. However, the availability of vaccines does not guarantee uptake, as evident in the Coronavirus 2019 pandemic. Therefore, as we consider current and future cancer vaccines, there are certain considerations to be mindful of to increase uptake among Native Americans such as the incidence of disease, social determinants of health, vaccine hesitancy, and historical exclusion in clinical trials. This paper primarily focuses on human papillomavirus (HPV) and potential vaccines for Native Americans. However, we also aim to inform researchers on factors that influence Native American choices surrounding vaccination and interventions including cancer therapies. We begin by providing an overview of the historical distrust and trauma Native Americans experience, both past and present. In addition, we offer guidance and considerations when engaging with sovereign Tribal Nations in vaccine development and clinical trials in order to increase trust and encourage vaccine uptake. |
Pearson, Talima; Hepp, Crystal; II, Robert Trotter T; Mbegbu, Mimi; Russakoff, Benjamin; Yagüe, David Panisello; Wood, Colin; Tucker-Morgan, Kara; Ceniceros, Kathya; Padilla, Cristina; Kyman, Shari; Villa, Francisco Genome Sequences of Community Carriage Strains of Staphylococcus aureus from Yuma, Arizona Journal Article Microbiology Resource Announcements, 10 (37), 2021. @article{Pearson2021, title = {Genome Sequences of Community Carriage Strains of Staphylococcus aureus from Yuma, Arizona}, author = {Talima Pearson and Crystal Hepp and Robert T Trotter II and Mimi Mbegbu and Benjamin Russakoff and David Panisello Yagüe and Colin Wood and Kara Tucker-Morgan and Kathya Ceniceros and Cristina Padilla and Shari Kyman and Francisco Villa}, url = {https://journals.asm.org/doi/10.1128/MRA.00449-21}, doi = {10.1128/MRA.00449-21}, year = {2021}, date = {2021-09-16}, journal = {Microbiology Resource Announcements}, volume = {10}, number = {37}, abstract = {Staphylococcus aureus exists as a pathogen and commensal. Individuals with asymptomatic carriage serve as a reservoir for transmission and are at increased risk of infecting themselves. In order to characterize the genomic diversity of S. aureus circulating in the community, we sequenced 166 genomes collected from individuals in Yuma, AZ.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Staphylococcus aureus exists as a pathogen and commensal. Individuals with asymptomatic carriage serve as a reservoir for transmission and are at increased risk of infecting themselves. In order to characterize the genomic diversity of S. aureus circulating in the community, we sequenced 166 genomes collected from individuals in Yuma, AZ. |
Ransdell, Lynda B; Wayment, Heidi A; Lopez, Nanette; Lorts, Cori; Schwartz, Anna L; Pugliesi, Karen; Pohl, Patricia S; Bycura, Dierdra; Camplain, Ricky Women, 1 (3), pp. 143-168, 2021. @article{Ransdell2021b, title = {The Impact of Resistance Training on Body Composition, Muscle Strength, and Functional Fitness in Older Women (45–80 Years): A Systematic Review (2010–2020)}, author = {Lynda B. Ransdell and Heidi A. Wayment and Nanette Lopez and Cori Lorts and Anna L. Schwartz and Karen Pugliesi and Patricia S. Pohl and Dierdra Bycura and Ricky Camplain}, url = {https://doi.org/10.3390/women1030014}, doi = {10.3390/women1030014}, year = {2021}, date = {2021-09-14}, journal = {Women}, volume = {1}, number = {3}, pages = {143-168}, abstract = {As women age, they typically experience a progressive decrease in skeletal muscle mass and strength, which can lead to a decline in functional fitness and quality of life. Resistance training (RT) has the potential to attenuate these losses. Although well established for men, evidence regarding the benefits of RT for women is sparse and inconsistent: prior reviews include too few studies with women and do not adequately examine the interactive or additive impacts of workload, modalities, and nutritional supplements on outcomes such as muscle mass (MM), body composition (BC), muscle strength (MS), and functional fitness (FF). The purpose of this review is to identify these gaps. Thirty-eight papers published between 2010 and 2020 (in English) represent 2519 subjects (mean age = 66.89 ± 4.91 years). Intervention averages include 2 to 3 × 50 min sessions across 15 weeks with 7 exercises per session and 11 repetitions per set. Twelve studies (32%) examined the impact of RT plus dietary manipulation. MM, MS, and FF showed positive changes after RT. Adding RT to fitness regimens for peri- to postmenopausal women is likely to have positive benefits.}, keywords = {}, pubstate = {published}, tppubtype = {article} } As women age, they typically experience a progressive decrease in skeletal muscle mass and strength, which can lead to a decline in functional fitness and quality of life. Resistance training (RT) has the potential to attenuate these losses. Although well established for men, evidence regarding the benefits of RT for women is sparse and inconsistent: prior reviews include too few studies with women and do not adequately examine the interactive or additive impacts of workload, modalities, and nutritional supplements on outcomes such as muscle mass (MM), body composition (BC), muscle strength (MS), and functional fitness (FF). The purpose of this review is to identify these gaps. Thirty-eight papers published between 2010 and 2020 (in English) represent 2519 subjects (mean age = 66.89 ± 4.91 years). Intervention averages include 2 to 3 × 50 min sessions across 15 weeks with 7 exercises per session and 11 repetitions per set. Twelve studies (32%) examined the impact of RT plus dietary manipulation. MM, MS, and FF showed positive changes after RT. Adding RT to fitness regimens for peri- to postmenopausal women is likely to have positive benefits. |
Teufel-Shone, Nicolette I; Chief, Carmenlita; Richards, Jennifer R; Clausen, Rebecca J; Yazzie, Alfred; Jr, Manley Begay A; Lothrop, Nathan; Yazzie, Janene; Begay, Andria B; Beamer, Paloma I; Chief, Karletta International Journal of Environmental Research and Public Health, 18 (17), pp. 9402, 2021. @article{Teufel-Shone2021, title = {Development of a Culturally Anchored Qualitative Approach to Conduct and Analyze Focus Group Narratives Collected in Diné (Navajo) Communities to Understand the Impacts of the Gold King Mine Spill of 2015}, author = {Nicolette I Teufel-Shone and Carmenlita Chief and Jennifer R Richards and Rebecca J Clausen and Alfred Yazzie and Manley A Begay Jr and Nathan Lothrop and Janene Yazzie and Andria B Begay and Paloma I Beamer and Karletta Chief}, url = { https://doi.org/10.3390/ijerph18179402}, doi = {10.3390/ijerph18179402}, year = {2021}, date = {2021-09-06}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {17}, pages = {9402}, abstract = {The Gold King Mine Spill (Spill) occurred in August 2015 upstream from Silverton, Colorado and released three million gallons of contaminated water into the Animas River, a tributary to the San Juan River that flows across the Navajo Nation. Using principles of community-engaged research, the Gold King Mine Spill Diné Exposure Project co-developed a culturally anchored approach to conduct focus groups and analyze narratives collected in three Diné (Navajo) communities along the San Juan River within 9 months of the Spill. Focus group questions were designed to document the socio-cultural impacts of the Spill. This paper: (1) outlines the partnerships and approvals; (2) describes focus group design, training, data collection and analysis; and (3) reflects on the use of a culturally anchored approach in Indigenous, specifically Diné-centered research. Diné social and cultural etiquette and concepts of relationality were used to adapt standard (non-Indigenous) qualitative methods. Findings describe community perceptions of short-term impacts of the disaster, as well as past and present injustices, communication related to the Spill, and concerns of persistent threats to Diné lifeways. The culturally anchored approach was critical in fostering trust with Diné participants and aligned with the candor of the discussions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Gold King Mine Spill (Spill) occurred in August 2015 upstream from Silverton, Colorado and released three million gallons of contaminated water into the Animas River, a tributary to the San Juan River that flows across the Navajo Nation. Using principles of community-engaged research, the Gold King Mine Spill Diné Exposure Project co-developed a culturally anchored approach to conduct focus groups and analyze narratives collected in three Diné (Navajo) communities along the San Juan River within 9 months of the Spill. Focus group questions were designed to document the socio-cultural impacts of the Spill. This paper: (1) outlines the partnerships and approvals; (2) describes focus group design, training, data collection and analysis; and (3) reflects on the use of a culturally anchored approach in Indigenous, specifically Diné-centered research. Diné social and cultural etiquette and concepts of relationality were used to adapt standard (non-Indigenous) qualitative methods. Findings describe community perceptions of short-term impacts of the disaster, as well as past and present injustices, communication related to the Spill, and concerns of persistent threats to Diné lifeways. The culturally anchored approach was critical in fostering trust with Diné participants and aligned with the candor of the discussions. |
Credo, Jonathan; Ingram, Jani C Perspective Developing Successful Collaborative Research Partnerships with AI/AN Communities Journal Article International Journal of Environmental Research and Public Health, 18 (17), pp. 9089, 2021. @article{Credo2021, title = {Perspective Developing Successful Collaborative Research Partnerships with AI/AN Communities}, author = {Jonathan Credo and Jani C Ingram}, url = {https://pubmed.ncbi.nlm.nih.gov/34501677/}, doi = {10.3390/ijerph18179089}, year = {2021}, date = {2021-08-28}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {17}, pages = {9089}, abstract = {In the United States, American Indian and Alaska Native (AI/AN) people are frequently under- or misrepresented in research and health statistics. A principal reason for this disparity is the lack of collaborative partnerships between researchers and tribes. There are hesitations from both academic Western scientists and tribal communities to establish new partnerships due to differences in cultural and scientific understanding, from data ownership and privacy to dissemination and project expansion. An infamous example is the mishandling of samples collected from the Havasupai Tribe by Arizona State University (ASU) scientists, leading to a legal battle between the tribe and ASU and ending in a moratorium of research with the Havasupai people. This paper will explore three successful and positive collaborations with a large and small tribe, including how the partnerships were established and the outcomes of the collaboration. In addition, the paper will provide perspective of what needs to be addressed by Western scientists if productive collaborations with tribal groups are to be established.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In the United States, American Indian and Alaska Native (AI/AN) people are frequently under- or misrepresented in research and health statistics. A principal reason for this disparity is the lack of collaborative partnerships between researchers and tribes. There are hesitations from both academic Western scientists and tribal communities to establish new partnerships due to differences in cultural and scientific understanding, from data ownership and privacy to dissemination and project expansion. An infamous example is the mishandling of samples collected from the Havasupai Tribe by Arizona State University (ASU) scientists, leading to a legal battle between the tribe and ASU and ending in a moratorium of research with the Havasupai people. This paper will explore three successful and positive collaborations with a large and small tribe, including how the partnerships were established and the outcomes of the collaboration. In addition, the paper will provide perspective of what needs to be addressed by Western scientists if productive collaborations with tribal groups are to be established. |
Ransdell, Lynda B; Wayment, Heidi A; Schwartz, Anna L; Lane, Taylor S; Baldwin, Julie A Precision mentoring (PM): a proposed framework for increasing research capacity in health-related disciplines Journal Article Medical Education Online, 2021. @article{Ransdell2021c, title = {Precision mentoring (PM): a proposed framework for increasing research capacity in health-related disciplines}, author = {Lynda B Ransdell and Heidi A Wayment and Anna L Schwartz and Taylor S Lane and Julie A Baldwin}, url = {https://www.tandfonline.com/doi/full/10.1080/10872981.2021.1964933}, doi = {10.1080/10872981.2021.1964933}, year = {2021}, date = {2021-08-24}, journal = {Medical Education Online}, abstract = {Research productivity is expected of academic faculty, and mentoring can facilitate it. This paper presents a framework for using mentoring to develop researchers in health disciplines. We utilized recent literature reviews, and experience developing researchers at an emerging research institution within the Research Centers for Minority Institutions (RCMI) program, to propose a precision mentoring (PM) framework for research development. Although we cannot precisely determine how much improvement was due to the PM framework, over the 4 years of our program, the quality and quantity of pilot project proposals (PPP) has increased, the number of external proposals submitted and funded by PPP investigators has increased, and the number of faculty participating in our program has increased. Surveys distributed to our 2021–22 PPP applicants who did not receive funding (n = 5/6 or 86.7%) revealed that new investigators most frequently sought mentoring related to career guidance (e.g., institutional culture, pre-tenure survival strategies), grant proposal basics (e.g., working with funding agencies, reviewing aims, balancing priorities, and enhancing scientific rigor), and identifying funding opportunities.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Research productivity is expected of academic faculty, and mentoring can facilitate it. This paper presents a framework for using mentoring to develop researchers in health disciplines. We utilized recent literature reviews, and experience developing researchers at an emerging research institution within the Research Centers for Minority Institutions (RCMI) program, to propose a precision mentoring (PM) framework for research development. Although we cannot precisely determine how much improvement was due to the PM framework, over the 4 years of our program, the quality and quantity of pilot project proposals (PPP) has increased, the number of external proposals submitted and funded by PPP investigators has increased, and the number of faculty participating in our program has increased. Surveys distributed to our 2021–22 PPP applicants who did not receive funding (n = 5/6 or 86.7%) revealed that new investigators most frequently sought mentoring related to career guidance (e.g., institutional culture, pre-tenure survival strategies), grant proposal basics (e.g., working with funding agencies, reviewing aims, balancing priorities, and enhancing scientific rigor), and identifying funding opportunities. |
Trotter, Robert; Baldwin, Julie A; Buck, Charles Loren; Remiker, Mark; Aguirre, Amanda; Milner, Trudie; Torres, Emma; von Hippel, Frank Arthur JMIR Research Protocol, 10 (8), 2021. @article{Trotter2021, title = {Health Impacts of Perchlorate and Pesticide Exposure: Protocol for Community-Engaged Research to Evaluate Environmental Toxicants in a US Border Community}, author = {Robert Trotter and Julie A Baldwin and Charles Loren Buck and Mark Remiker and Amanda Aguirre and Trudie Milner and Emma Torres and Frank Arthur von Hippel}, url = {https://pubmed.ncbi.nlm.nih.gov/34383679/}, doi = {10.2196/15864}, year = {2021}, date = {2021-08-11}, journal = {JMIR Research Protocol}, volume = {10}, number = {8}, abstract = {The Northern Arizona University (NAU) Center for Health Equity Research (CHER) is conducting community-engaged health research involving "environmental scans" in Yuma County in collaboration with community health stakeholders, including the Yuma Regional Medical Center (YRMC), Regional Center for Border Health, Inc. (RCBH), Campesinos Sin Fronteras (CSF), Yuma County Public Health District, and government agencies and nongovernmental organizations (NGOs) working on border health issues. The purpose of these efforts is to address community-generated environmental health hazards identified through ongoing coalitions among NAU, and local health care and research institutions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Northern Arizona University (NAU) Center for Health Equity Research (CHER) is conducting community-engaged health research involving "environmental scans" in Yuma County in collaboration with community health stakeholders, including the Yuma Regional Medical Center (YRMC), Regional Center for Border Health, Inc. (RCBH), Campesinos Sin Fronteras (CSF), Yuma County Public Health District, and government agencies and nongovernmental organizations (NGOs) working on border health issues. The purpose of these efforts is to address community-generated environmental health hazards identified through ongoing coalitions among NAU, and local health care and research institutions. |
Schwartz, Anna L; Terry, Christopher M Returning to Sport: Female Athletes Living with and beyond Cancer Journal Article International Journal of Environmental Research and Public Health, 18 (15), 2021. @article{Schwartz2021, title = {Returning to Sport: Female Athletes Living with and beyond Cancer}, author = {Anna L. Schwartz and Christopher M. Terry}, url = {https://doi.org/10.3390/ijerph18158151}, doi = {10.3390/ijerph18158151}, year = {2021}, date = {2021-08-01}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {15}, abstract = {Many athletes living with and beyond cancer can continue to train and, in some cases, compete during treatment. Following cancer treatment, athletes can return to competitive sport but need to learn to adapt their physical strength and training to the lingering effects of cancer. It is critical for oncology healthcare providers to use the principles of assess, refer and advise to exercise oncology programs that are appropriate for the individual. Managing side effects of treatment is key to being able to train during and immediately following cancer treatment. Keen attention to fatigue is important at any point in the cancer spectrum to avoid overtraining and optimize the effects of training. Resources are introduced for providers to reference and direct patients to information for psychosocial support and instruction. The purpose of this paper is to present exercise considerations during and after cancer treatment for athletic cancer survivors.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Many athletes living with and beyond cancer can continue to train and, in some cases, compete during treatment. Following cancer treatment, athletes can return to competitive sport but need to learn to adapt their physical strength and training to the lingering effects of cancer. It is critical for oncology healthcare providers to use the principles of assess, refer and advise to exercise oncology programs that are appropriate for the individual. Managing side effects of treatment is key to being able to train during and immediately following cancer treatment. Keen attention to fatigue is important at any point in the cancer spectrum to avoid overtraining and optimize the effects of training. Resources are introduced for providers to reference and direct patients to information for psychosocial support and instruction. The purpose of this paper is to present exercise considerations during and after cancer treatment for athletic cancer survivors. |
Hardy, Lisa J; Mana, Adi; Mundell, Leah; Benheim, Sharón; Morales, Kayla Torres; Sagy, Shifra Living in opposition: How women in the United States cope in spite of mistrust of federal leadership during the pandemic of Covid-19 Journal Article Journal of Community Psychology, 49 (6), pp. 2059-2070, 2021, ISBN: 10.1002/jcop.22544. @article{Hardy2021, title = {Living in opposition: How women in the United States cope in spite of mistrust of federal leadership during the pandemic of Covid-19}, author = {Lisa J Hardy and Adi Mana and Leah Mundell and Sharón Benheim and Kayla Torres Morales and Shifra Sagy}, url = {https://pubmed.ncbi.nlm.nih.gov/33729586/}, doi = {10.1002/jcop.22544}, isbn = {10.1002/jcop.22544}, year = {2021}, date = {2021-08-01}, journal = {Journal of Community Psychology}, volume = {49}, number = {6}, pages = {2059-2070}, abstract = {International research collaborators conducted research investigating sociocultural responses to the Covid-19 pandemic. Our mixed methods research design includes surveys and interviews conducted between March and September of 2020 including 249 of 506 survey responses and 18 of 50 in-depth, exploratory, semi-structured interviews with self-defined politically left-leaning women in the United States. We employ a sequential design to analyze statistical and qualitative data. Despite international data suggesting that trust in federal governments reduces anxiety, women who did not trust and actively opposed the Trump administration reported lower levels of anxiety than expected. Results indicate reliance on and development of new forms of connection that seem to mitigate symptomatic anxieties when living in opposition. Women living in opposition to the leadership of the federal government use and develop resources to help them cope. Research on coping strategies and mental health and anxiety during crisis can inform recommendations for ways to support and strengthen sense of coherence during tumultuous times.}, keywords = {}, pubstate = {published}, tppubtype = {article} } International research collaborators conducted research investigating sociocultural responses to the Covid-19 pandemic. Our mixed methods research design includes surveys and interviews conducted between March and September of 2020 including 249 of 506 survey responses and 18 of 50 in-depth, exploratory, semi-structured interviews with self-defined politically left-leaning women in the United States. We employ a sequential design to analyze statistical and qualitative data. Despite international data suggesting that trust in federal governments reduces anxiety, women who did not trust and actively opposed the Trump administration reported lower levels of anxiety than expected. Results indicate reliance on and development of new forms of connection that seem to mitigate symptomatic anxieties when living in opposition. Women living in opposition to the leadership of the federal government use and develop resources to help them cope. Research on coping strategies and mental health and anxiety during crisis can inform recommendations for ways to support and strengthen sense of coherence during tumultuous times. |
Tippens, Julie A; Hatton-Bowers, Holly; Honomichl, Ryan; Wheeler, Lorey A; Miamidian, Helen M; Bash, Kirstie L; Smith, Michelle Howell C; Nyaoro, Dulo; Byrd, Joshua J; Packard, Samuel E; Teufel-Shone, Nicolette I Psychological distress prevalence and associated stressors and supports among urban-displaced Congolese adults in Kenya Journal Article American Journal of Orthopsychiatry, 91 (5), pp. 626–634, 2021. @article{Tippens2021, title = {Psychological distress prevalence and associated stressors and supports among urban-displaced Congolese adults in Kenya}, author = {Julie A. Tippens and Holly Hatton-Bowers and Ryan Honomichl and Lorey A. Wheeler and Helen M. Miamidian and Kirstie L. Bash and Michelle C. Howell Smith and Dulo Nyaoro and Joshua J Byrd and Samuel E. Packard and Nicolette I. Teufel-Shone}, url = {https://doi.org/10.1037/ort0000564}, doi = {10.1037/ort0000564}, year = {2021}, date = {2021-07-01}, journal = {American Journal of Orthopsychiatry}, volume = {91}, number = {5}, pages = {626–634}, abstract = {There is limited understanding of the prevalence of psychological distress and associated stressors and supports among displaced adults in low- and middle-income first asylum countries. Method: This article reports the findings of a cross-sectional study. We recruited 245 Congolese adults (18–80 years) residing in Nairobi, Kenya using snowball sampling. Data were collected using an interviewer-administered questionnaire consisting of sociodemographic characteristics, the Self-Reporting Questionnaire (SRQ-20), and a locally developed stressors and supports survey. We used multivariable logistic regression to examine associations among sociodemographic, stressor, and support variables and the likelihood of experiencing psychological distress. Results: More than half of the participants (52.8%) reported symptoms indicative of psychological distress. Factors associated with increased psychological distress included perceiving to have a useful role in one’s family or community, AOR = 1.85; 95% CI [1.1.17, 3.11], p = .012, feeling confused or not knowing what to do, AOR = 2.13; 95% CI [1.20, 4.6], p = .014, and feeling afraid to leave home for medical/health care to help with an illness, AOR = 1.57; 95% CI [1.17, 2.15], p < .01. Additionally, ethnic Banyamulenge Congolese adults without legal refugee status had an increased likelihood of experiencing psychological distress, AOR = .07; 95% CI [0, .74], p = .035. Conclusion: Future research is warranted to understand how to implement targeted mental health and psychosocial support (MHPSS) to improve urban-displaced adults’ sense of safety and belonging. Our findings suggest that legal refugee status is an important structural determinant of mental health, which should be considered in MHPSS practice and policy.}, keywords = {}, pubstate = {published}, tppubtype = {article} } There is limited understanding of the prevalence of psychological distress and associated stressors and supports among displaced adults in low- and middle-income first asylum countries. Method: This article reports the findings of a cross-sectional study. We recruited 245 Congolese adults (18–80 years) residing in Nairobi, Kenya using snowball sampling. Data were collected using an interviewer-administered questionnaire consisting of sociodemographic characteristics, the Self-Reporting Questionnaire (SRQ-20), and a locally developed stressors and supports survey. We used multivariable logistic regression to examine associations among sociodemographic, stressor, and support variables and the likelihood of experiencing psychological distress. Results: More than half of the participants (52.8%) reported symptoms indicative of psychological distress. Factors associated with increased psychological distress included perceiving to have a useful role in one’s family or community, AOR = 1.85; 95% CI [1.1.17, 3.11], p = .012, feeling confused or not knowing what to do, AOR = 2.13; 95% CI [1.20, 4.6], p = .014, and feeling afraid to leave home for medical/health care to help with an illness, AOR = 1.57; 95% CI [1.17, 2.15], p < .01. Additionally, ethnic Banyamulenge Congolese adults without legal refugee status had an increased likelihood of experiencing psychological distress, AOR = .07; 95% CI [0, .74], p = .035. Conclusion: Future research is warranted to understand how to implement targeted mental health and psychosocial support (MHPSS) to improve urban-displaced adults’ sense of safety and belonging. Our findings suggest that legal refugee status is an important structural determinant of mental health, which should be considered in MHPSS practice and policy. |
Camplain, Ricky; Lininger, Monica R; Baldwin, Julie A; II, Robert Trotter T Cardiovascular Risk Factors among Individuals Incarcerated in an Arizona County Jail Journal Article International Journal of Environmental Research and Public Health, 18 (13), 2021. @article{Camplain2021, title = {Cardiovascular Risk Factors among Individuals Incarcerated in an Arizona County Jail}, author = {Ricky Camplain and Monica R. Lininger and Julie A. Baldwin and Robert T. Trotter II}, url = {https://doi.org/10.3390/ijerph18137007}, doi = {10.3390/ijerph18137007}, year = {2021}, date = {2021-06-30}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {13}, abstract = {We aimed to estimate the prevalence of cardiovascular risk factors, including hypertension, diabetes, high cholesterol, cigarette smoking, alcohol consumption, and obesity among a sample of individuals incarcerated in an Arizona county jail and compare prevalence estimates to a matched non-institutionalized population. From 2017–2018, individuals housed at a county jail completed a cross-sectional health survey. We estimated the prevalence of hypertension, diabetes, cholesterol, overweight/obesity, cigarette smoking, binge drinking, and self-reported health among individuals incarcerated. We compared prevalence estimates of cardiovascular risk factors to a matched sample of 2017–2018 NHANES participants. Overall, 35.9%, 7.7%, and 17.8% of individuals incarcerated in jail self-reported hypertension, diabetes, and high cholesterol, respectively. Of individuals incarcerated, 59.6% were overweight or obese and 36.8% self-reported fair or poor general health. Over half of individuals incarcerated reported ever smoking cigarettes (72.3%) and binge drinking (60.7%). Compared to a matched sample of NHANES participants, individuals incarcerated in jail had a statistically higher prevalence of cigarette smoking and binge drinking. Screening of cardiovascular risk factors and providing preventive measures and interventions, such as healthy eating, physical activity, or pharmacological adherence interventions, while individuals are incarcerated may contribute to the prevention and management of cardiovascular risk factors and, eventually, cardiovascular disease.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We aimed to estimate the prevalence of cardiovascular risk factors, including hypertension, diabetes, high cholesterol, cigarette smoking, alcohol consumption, and obesity among a sample of individuals incarcerated in an Arizona county jail and compare prevalence estimates to a matched non-institutionalized population. From 2017–2018, individuals housed at a county jail completed a cross-sectional health survey. We estimated the prevalence of hypertension, diabetes, cholesterol, overweight/obesity, cigarette smoking, binge drinking, and self-reported health among individuals incarcerated. We compared prevalence estimates of cardiovascular risk factors to a matched sample of 2017–2018 NHANES participants. Overall, 35.9%, 7.7%, and 17.8% of individuals incarcerated in jail self-reported hypertension, diabetes, and high cholesterol, respectively. Of individuals incarcerated, 59.6% were overweight or obese and 36.8% self-reported fair or poor general health. Over half of individuals incarcerated reported ever smoking cigarettes (72.3%) and binge drinking (60.7%). Compared to a matched sample of NHANES participants, individuals incarcerated in jail had a statistically higher prevalence of cigarette smoking and binge drinking. Screening of cardiovascular risk factors and providing preventive measures and interventions, such as healthy eating, physical activity, or pharmacological adherence interventions, while individuals are incarcerated may contribute to the prevention and management of cardiovascular risk factors and, eventually, cardiovascular disease. |
Akintobi, Tabia Henry; Sheikhattari, Payam; Shaffer, Emma; Evans, Christina L; Braun, Kathryn L; Sy, Angela U; Mancera, Bibiana; Campa, Adriana; Miller, Stephania T; Sarpong, Daniel; Holliday, Rhonda; Jimenez-Chavez, Julio; Khan, Shafiq; Hinton, Cimona; Sellars-Bates, Kimberly; Ajewole, Veronica; Teufel-Shone, Nicolette I International Journal of Environmental Research and Public Health, 18 (12), 2021. @article{Akintobi2021, title = {Community Engagement Practices at Research Centers in U.S. Minority Institutions: Priority Populations and Innovative Approaches to Advancing Health Disparities Research}, author = {Tabia Henry Akintobi and Payam Sheikhattari and Emma Shaffer and Christina L. Evans and Kathryn L. Braun and Angela U. Sy and Bibiana Mancera and Adriana Campa and Stephania T. Miller and Daniel Sarpong and Rhonda Holliday and Julio Jimenez-Chavez and Shafiq Khan and Cimona Hinton and Kimberly Sellars-Bates and Veronica Ajewole and Nicolette I. Teufel-Shone}, url = {https://doi.org/10.3390/ijerph18126675}, doi = {10.3390/ijerph18126675}, year = {2021}, date = {2021-06-21}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {12}, abstract = {This paper details U.S. Research Centers in Minority Institutions (RCMI) Community Engagement Cores (CECs): (1) unique and cross-cutting components, focus areas, specific aims, and target populations; and (2) approaches utilized to build or sustain trust towards community participation in research. A mixed-method data collection approach was employed for this cross-sectional study of current or previously funded RCMIs. A total of 18 of the 25 institutions spanning 13 U.S. states and territories participated. CEC specific aims were to support community engaged research (94%); to translate and disseminate research findings (88%); to develop partnerships (82%); and to build capacity around community research (71%). Four open-ended questions, qualitative analysis, and comparison of the categories led to the emergence of two supporting themes: (1) establishing trust between the community-academic collaborators and within the community and (2) building collaborative relationships. An overarching theme, building community together through trust and meaningful collaborations, emerged from the supporting themes and subthemes. The RCMI institutions and their CECs serve as models to circumvent the historical and current challenges to research in communities disproportionately affected by health disparities. Lessons learned from these cores may help other institutions who want to build community trust in and capacities for research that addresses community-related health concerns.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This paper details U.S. Research Centers in Minority Institutions (RCMI) Community Engagement Cores (CECs): (1) unique and cross-cutting components, focus areas, specific aims, and target populations; and (2) approaches utilized to build or sustain trust towards community participation in research. A mixed-method data collection approach was employed for this cross-sectional study of current or previously funded RCMIs. A total of 18 of the 25 institutions spanning 13 U.S. states and territories participated. CEC specific aims were to support community engaged research (94%); to translate and disseminate research findings (88%); to develop partnerships (82%); and to build capacity around community research (71%). Four open-ended questions, qualitative analysis, and comparison of the categories led to the emergence of two supporting themes: (1) establishing trust between the community-academic collaborators and within the community and (2) building collaborative relationships. An overarching theme, building community together through trust and meaningful collaborations, emerged from the supporting themes and subthemes. The RCMI institutions and their CECs serve as models to circumvent the historical and current challenges to research in communities disproportionately affected by health disparities. Lessons learned from these cores may help other institutions who want to build community trust in and capacities for research that addresses community-related health concerns. |
Jones, Christopher W; Morales, Crystal G; Eltiste, Sharon L; Yanchik-Slade, Francine E; Lee, Naomi R; Nilsson, Bradley L Capacity for increased surface area in the hydrophobic core of β-sheet peptide bilayer nanoribbons Journal Article Journal of Peptide Science, 27 , 2021. @article{Jones2021, title = {Capacity for increased surface area in the hydrophobic core of β-sheet peptide bilayer nanoribbons}, author = {Christopher W. Jones and Crystal G. Morales and Sharon L. Eltiste and Francine E. Yanchik-Slade and Naomi R. Lee and Bradley L. Nilsson}, url = {https://doi.org/10.1002/psc.3334}, doi = {10.1002/psc.3334}, year = {2021}, date = {2021-06-20}, journal = {Journal of Peptide Science}, volume = {27}, abstract = {Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE)2-NH2 peptides (X = hydrophobic residue). A series of Ac-(XKXE)2-NH2 peptides incorporating aromatic amino acids of increasing molecular volume and steric profile (X = phenylalanine [Phe], homophenylalanine [Hph], tryptophan [Trp], 1-naphthylalanine [1-Nal], 2-naphthylalanine [2-Nal], or biphenylalanine [Bip]) were assessed to determine substitution effects on self-assembly propensity and on morphology of the resulting nanoribbon structures. Additional studies were conducted to determine the effects of incorporating amino acids of differing steric profile in the hydrophobic core (Ac-X1KFEFKFE-NH2 and Ac-(X1,5KFE)-NH2 peptides, X = Trp or Bip). Spectroscopic analysis by circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy indicated β-sheet formation for all variants. Self-assembly rate increased with peptide hydrophobicity; increased molecular volume of the hydrophobic side chain groups did not appear to induce kinetic penalties on self-assembly rates. Transmission electron microscopy (TEM) imaging indicated variation in fibril morphology as a function of amino acid in the X positions. This study confirms that hydrophobicity of amphipathic Ac-(XKXE)2-NH2 peptides correlates to self-assembly propensity and that the hydrophobic core of the resulting nanoribbon bilayers has a significant capacity to accommodate sterically demanding functional groups. These findings provide insight that may be used to guide the exploitation of self-assembled amphipathic peptides as functional biomaterials. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE)2-NH2 peptides (X = hydrophobic residue). A series of Ac-(XKXE)2-NH2 peptides incorporating aromatic amino acids of increasing molecular volume and steric profile (X = phenylalanine [Phe], homophenylalanine [Hph], tryptophan [Trp], 1-naphthylalanine [1-Nal], 2-naphthylalanine [2-Nal], or biphenylalanine [Bip]) were assessed to determine substitution effects on self-assembly propensity and on morphology of the resulting nanoribbon structures. Additional studies were conducted to determine the effects of incorporating amino acids of differing steric profile in the hydrophobic core (Ac-X1KFEFKFE-NH2 and Ac-(X1,5KFE)-NH2 peptides, X = Trp or Bip). Spectroscopic analysis by circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy indicated β-sheet formation for all variants. Self-assembly rate increased with peptide hydrophobicity; increased molecular volume of the hydrophobic side chain groups did not appear to induce kinetic penalties on self-assembly rates. Transmission electron microscopy (TEM) imaging indicated variation in fibril morphology as a function of amino acid in the X positions. This study confirms that hydrophobicity of amphipathic Ac-(XKXE)2-NH2 peptides correlates to self-assembly propensity and that the hydrophobic core of the resulting nanoribbon bilayers has a significant capacity to accommodate sterically demanding functional groups. These findings provide insight that may be used to guide the exploitation of self-assembled amphipathic peptides as functional biomaterials. |
Eaves, Emery R; Barber, Jarrett; Whealy, Ryann; Clancey, Sara A; Wright, Rita; Cocking, Jill Hager; Spadafino, Joseph; Hepp, Crystal M Characterization of neonatal opioid withdrawal syndrome in Arizona from 2010-2017 Journal Article PLOS ONE, 16 (6), 2021. @article{Eaves2021, title = {Characterization of neonatal opioid withdrawal syndrome in Arizona from 2010-2017}, author = {Emery R. Eaves and Jarrett Barber and Ryann Whealy and Sara A. Clancey and Rita Wright and Jill Hager Cocking and Joseph Spadafino and Crystal M. Hepp }, url = {https://doi.org/10.1371/journal.pone.0248476}, doi = {10.1371/journal.pone.0248476}, year = {2021}, date = {2021-06-03}, journal = {PLOS ONE}, volume = {16}, number = {6}, abstract = {In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported. }, keywords = {}, pubstate = {published}, tppubtype = {article} } In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported. |
2021 |
Remiker, Mark; Sabo, Samantha; Jiménez, Dulce; Longorio, Alexandra Samarron; Chief, Carmenlita; Williamson, Heather; Teufel-Shone, Nicolette Using a Multisectoral Approach to Advance Health Equity in Rural Arizona: Community-Engaged Survey Development and Implementation Study Journal Article JMIR Formative Research, 5 (5), 2021. @article{Remiker2021, title = {Using a Multisectoral Approach to Advance Health Equity in Rural Arizona: Community-Engaged Survey Development and Implementation Study}, author = {Mark Remiker and Samantha Sabo and Dulce Jiménez and Alexandra Samarron Longorio and Carmenlita Chief and Heather Williamson and Nicolette Teufel-Shone }, url = {https://formative.jmir.org/2021/5/e25577}, doi = {10.2196/25577}, year = {2021}, date = {2021-12-05}, journal = {JMIR Formative Research}, volume = {5}, number = {5}, abstract = {Over the past decade, public health research and practice sectors have shifted their focus away from identifying health disparities and toward addressing the social, environmental, and economic determinants of health equity. Given the complex and interrelated nature of these determinants, developing policies that will advance health equity requires collaboration across sectors outside of health. However, engaging various stakeholder groups, tapping into their unique knowledge systems, and identifying common objectives across sectors is difficult and time consuming and can impede collaborative efforts.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Over the past decade, public health research and practice sectors have shifted their focus away from identifying health disparities and toward addressing the social, environmental, and economic determinants of health equity. Given the complex and interrelated nature of these determinants, developing policies that will advance health equity requires collaboration across sectors outside of health. However, engaging various stakeholder groups, tapping into their unique knowledge systems, and identifying common objectives across sectors is difficult and time consuming and can impede collaborative efforts. |
Baldwin, Julie A; II, Robert Trotter T; Remiker, Mark; Buck, Loren C; Aguirre, Amanda; Milner, Trudie; Torres, Emma; von Hippel, Frank A A Community-Engaged Approach to Environmental Health Research: Process and Lessons Learned Journal Article Muse, 15 (4), pp. 533-540, 2021. @article{Baldwin2021, title = {A Community-Engaged Approach to Environmental Health Research: Process and Lessons Learned}, author = {Julie A. Baldwin and Robert T. Trotter II and Mark Remiker and C. Loren Buck and Amanda Aguirre and Trudie Milner and Emma Torres and Frank A. von Hippel}, url = {https://muse.jhu.edu/article/842128}, doi = {10.1353/cpr.2021.0043}, year = {2021}, date = {2021-12-01}, journal = {Muse}, volume = {15}, number = {4}, pages = {533-540}, abstract = {Background: This study used a community-engaged approach to examine associations between environmental contaminants and health outcomes among residents of Yuma, Arizona. Our team conducted a process evaluation to assess scientific rigor and adherence to community engagement principles. Objective: Our evaluation focused on four dimensions of community-based participatory research: 1) context, 2) group dynamics, 3) intervention and research, and 4) outcomes. Methods: Interviews were conducted with key informants from community partner organizations. Thematic analysis was used to evaluate community partners' experiences with our collaborative process. Lessons Learned: Community partners reported collaborating to establish research goals, recruit participants, collect data, plan analyses, and formulate dissemination strategies. Training needs, roles, and expectations of community partners varied based on available resources, prior research experience, and perceived research challenges. Conclusions: Leveraging community-engaged principles for studies of environmental contamination can expedite recruitment efforts and stimulate action to improve health outcomes.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: This study used a community-engaged approach to examine associations between environmental contaminants and health outcomes among residents of Yuma, Arizona. Our team conducted a process evaluation to assess scientific rigor and adherence to community engagement principles. Objective: Our evaluation focused on four dimensions of community-based participatory research: 1) context, 2) group dynamics, 3) intervention and research, and 4) outcomes. Methods: Interviews were conducted with key informants from community partner organizations. Thematic analysis was used to evaluate community partners' experiences with our collaborative process. Lessons Learned: Community partners reported collaborating to establish research goals, recruit participants, collect data, plan analyses, and formulate dissemination strategies. Training needs, roles, and expectations of community partners varied based on available resources, prior research experience, and perceived research challenges. Conclusions: Leveraging community-engaged principles for studies of environmental contamination can expedite recruitment efforts and stimulate action to improve health outcomes. |
Lee, Michele S; Peart, Jillian R; Armin, Julie S; Williamson, Heather J Journal of Health Disparities Research and Practice, 14 (3), pp. 2, 2021, ISSN: 2166-5222. @article{Lee2021, title = {A Scoping Review of Barriers and Facilitators to Pap Testing in Women with Disabilities and Serious Mental Illnesses: Thirty Years After the Americans with Disabilities Act}, author = {Michele S. Lee and Jillian R. Peart and Julie S. Armin and Heather J. Williamson}, url = {https://digitalscholarship.unlv.edu/jhdrp/vol14/iss3/2}, issn = {2166-5222}, year = {2021}, date = {2021-11-15}, journal = {Journal of Health Disparities Research and Practice}, volume = {14}, number = {3}, pages = {2}, abstract = {Thirty years after the Americans with Disabilities Act (ADA) was passed, promising equal access to health services for people with disabilities and serious mental illness, research on Pap testing continues to uncover health disparities among women with disabilities and women with serious mental illnesses, including those that identify as an ethnic/racial minority.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Thirty years after the Americans with Disabilities Act (ADA) was passed, promising equal access to health services for people with disabilities and serious mental illness, research on Pap testing continues to uncover health disparities among women with disabilities and women with serious mental illnesses, including those that identify as an ethnic/racial minority. |
Kumar, Amit; Roy, Indrakshi; Bosch, Pamela; Fehnel, Corey; Garnica, Nicholas; Cook, Jon; Warren, Meghan; Karmarkar, Amol Medicare Claim–Based National Institutes of Health Stroke Scale to Predict 30-Day Mortality and Hospital Readmission Journal Article Journal of General Internal Medicine, 2021. @article{Kumar2021, title = {Medicare Claim–Based National Institutes of Health Stroke Scale to Predict 30-Day Mortality and Hospital Readmission}, author = {Amit Kumar and Indrakshi Roy and Pamela Bosch and Corey Fehnel and Nicholas Garnica and Jon Cook and Meghan Warren and Amol Karmarkar}, url = {https://doi.org/10.1007/s11606-021-07162-0}, doi = {10.1007/s11606-021-07162-0}, year = {2021}, date = {2021-10-26}, journal = {Journal of General Internal Medicine}, abstract = {The Centers for Medicare and Medicaid Services (CMS) penalizes hospitals for higher than expected 30-day mortality rates using methods without accounting for condition severity risk adjustment. For patients with stroke, CMS claims did not quantify stroke severity until recently, when the National Institutes of Health Stroke Scale (NIHSS) reporting began. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Centers for Medicare and Medicaid Services (CMS) penalizes hospitals for higher than expected 30-day mortality rates using methods without accounting for condition severity risk adjustment. For patients with stroke, CMS claims did not quantify stroke severity until recently, when the National Institutes of Health Stroke Scale (NIHSS) reporting began. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. Examine the predictive ability of claim-based NIHSS to predict 30-day mortality and 30-day hospital readmission in patients with ischemic stroke. |
Rivera-Hernandez, Maricruz; Kumar, Amit; Roy, Indrakshi; Fashaw-Walters, Shekinah; Baldwin, Julie A Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer’s Disease and Related Dementias Journal Article Journal of Aging and Health, 2021. @article{Rivera-Hernandez2021, title = {Quality of Care and Outcomes Among a Diverse Group of Long-Term Care Residents With Alzheimer’s Disease and Related Dementias}, author = {Maricruz Rivera-Hernandez and Amit Kumar and Indrakshi Roy and Shekinah Fashaw-Walters and Julie A. Baldwin}, url = {https://doi.org/10.1177/08982643211043319}, doi = {10.1177/08982643211043319}, year = {2021}, date = {2021-10-11}, journal = {Journal of Aging and Health}, abstract = {This article assessed whether disparities among ADRD Medicare beneficiaries existed in five different long-stay quality measures. Methods: We linked individual-level data and facility-level characteristics. The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) received an antipsychotic medication; 3) experienced one/more falls with major injury; 4) were physically restrained; and 5) lost too much weight. Results: In 2016, there were 1,005,781 Medicare Advantage and fee-for-service long-term residents. About 78% were White, 13% Black, 2% Asian/Pacific Islander (Asian/PI), 6% Hispanic, and 0.4% American Indian/Alaska Native (AI/AN). Whites reported higher use of antipsychotic medications along with Hispanics and AI/AN (28%, 28%, and 27%, respectively). Similarly, Whites and AIs/ANs reported having one/more falls compared to the other groups (9% and 8%, respectively). Discussion: Efforts to understand disparities in access and quality of care among American Indians/Alaska Natives are needed, especially post-pandemic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This article assessed whether disparities among ADRD Medicare beneficiaries existed in five different long-stay quality measures. Methods: We linked individual-level data and facility-level characteristics. The main quality outcomes included whether residents: 1) were assessed/appropriately given the seasonal influenza vaccine; 2) received an antipsychotic medication; 3) experienced one/more falls with major injury; 4) were physically restrained; and 5) lost too much weight. Results: In 2016, there were 1,005,781 Medicare Advantage and fee-for-service long-term residents. About 78% were White, 13% Black, 2% Asian/Pacific Islander (Asian/PI), 6% Hispanic, and 0.4% American Indian/Alaska Native (AI/AN). Whites reported higher use of antipsychotic medications along with Hispanics and AI/AN (28%, 28%, and 27%, respectively). Similarly, Whites and AIs/ANs reported having one/more falls compared to the other groups (9% and 8%, respectively). Discussion: Efforts to understand disparities in access and quality of care among American Indians/Alaska Natives are needed, especially post-pandemic. |
Pollitt, Amanda M; Roberts, Tangela S Internalized Binegativity, LGBQ + Community Involvement, and Definitions of Bisexuality Journal Article Journal of Bisexuality, 21 (3), pp. 357-379, 2021. @article{Pollitt2021, title = {Internalized Binegativity, LGBQ + Community Involvement, and Definitions of Bisexuality}, author = {Amanda M. Pollitt and Tangela S. Roberts}, url = {https://doi.org/10.1080/15299716.2021.1984363}, doi = {10.1080/15299716.2021.1984363}, year = {2021}, date = {2021-10-06}, journal = {Journal of Bisexuality}, volume = {21}, number = {3}, pages = {357-379}, abstract = {Bisexual people can internalize stigma from both heterosexual and gay/lesbian communities, which often occurs in the form of monosexism, the belief that people should only be attracted to one gender. Although community involvement is protective for lesbian, gay, bisexual, and queer+ (LGBQ+) people, bisexual people may benefit more from bisexual-specific communities than LGBQ + communities because of monosexism. Further, how bisexual people define their identity may be related to internalized binegativity, especially given the historical invisibility of bisexuality in mainstream media and recent debates about the definition of bisexuality within LGBQ + communities. We examined LGBQ + and bisexual-specific community involvement, definitions of bisexuality, and internalized binegativity among an online sample of 816 bisexual adults. Multivariate regression analyses showed that those with spectrum definitions, which acknowledged a nuanced understanding of sex, gender, and sexuality, reported lower internalized binegativity than those with binary definitions, which described sexuality as consistent with mainstream norms. Involvement in LGBQ + communities, but not bisexual communities, was associated with lower internalized binegativity. There was no interaction between type of definition and type of community involvement. Our results suggest that broad community involvement may be protective for internalized binegativity, but findings should be considered in light of a lack of well-funded, local bisexual communities. The current study adds to a growing literature on sexual minority stressors among bisexual people, a population that continues to be understudied.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Bisexual people can internalize stigma from both heterosexual and gay/lesbian communities, which often occurs in the form of monosexism, the belief that people should only be attracted to one gender. Although community involvement is protective for lesbian, gay, bisexual, and queer+ (LGBQ+) people, bisexual people may benefit more from bisexual-specific communities than LGBQ + communities because of monosexism. Further, how bisexual people define their identity may be related to internalized binegativity, especially given the historical invisibility of bisexuality in mainstream media and recent debates about the definition of bisexuality within LGBQ + communities. We examined LGBQ + and bisexual-specific community involvement, definitions of bisexuality, and internalized binegativity among an online sample of 816 bisexual adults. Multivariate regression analyses showed that those with spectrum definitions, which acknowledged a nuanced understanding of sex, gender, and sexuality, reported lower internalized binegativity than those with binary definitions, which described sexuality as consistent with mainstream norms. Involvement in LGBQ + communities, but not bisexual communities, was associated with lower internalized binegativity. There was no interaction between type of definition and type of community involvement. Our results suggest that broad community involvement may be protective for internalized binegativity, but findings should be considered in light of a lack of well-funded, local bisexual communities. The current study adds to a growing literature on sexual minority stressors among bisexual people, a population that continues to be understudied. |
Bordeaux, Skyler J; Baca, Anthony W; Begay, Rene L; Gachupin, Francine C; Caporaso, Gregory J; Herbst-Kralovetz, Melissa M; Lee, Naomi R Designing Inclusive HPV Cancer Vaccines and Increasing Uptake among Native Americans-A Cultural Perspective Review Journal Article Current Oncology, 28 (5), pp. 3705-3716, 2021. @article{Bordeaux2021, title = {Designing Inclusive HPV Cancer Vaccines and Increasing Uptake among Native Americans-A Cultural Perspective Review}, author = {Skyler J Bordeaux and Anthony W Baca and Rene L Begay and Francine C Gachupin and J Gregory Caporaso and Melissa M Herbst-Kralovetz and Naomi R Lee}, url = {https://www.mdpi.com/1718-7729/28/5/316}, doi = {10.3390/curroncol28050316}, year = {2021}, date = {2021-09-24}, journal = {Current Oncology}, volume = {28}, number = {5}, pages = {3705-3716}, abstract = {Despite a global and nationwide decrease, Native Americans continue to experience high rates of cancer morbidity and mortality. Vaccination is one approach to decrease cancer incidence such as the case of cervical cancer. However, the availability of vaccines does not guarantee uptake, as evident in the Coronavirus 2019 pandemic. Therefore, as we consider current and future cancer vaccines, there are certain considerations to be mindful of to increase uptake among Native Americans such as the incidence of disease, social determinants of health, vaccine hesitancy, and historical exclusion in clinical trials. This paper primarily focuses on human papillomavirus (HPV) and potential vaccines for Native Americans. However, we also aim to inform researchers on factors that influence Native American choices surrounding vaccination and interventions including cancer therapies. We begin by providing an overview of the historical distrust and trauma Native Americans experience, both past and present. In addition, we offer guidance and considerations when engaging with sovereign Tribal Nations in vaccine development and clinical trials in order to increase trust and encourage vaccine uptake.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Despite a global and nationwide decrease, Native Americans continue to experience high rates of cancer morbidity and mortality. Vaccination is one approach to decrease cancer incidence such as the case of cervical cancer. However, the availability of vaccines does not guarantee uptake, as evident in the Coronavirus 2019 pandemic. Therefore, as we consider current and future cancer vaccines, there are certain considerations to be mindful of to increase uptake among Native Americans such as the incidence of disease, social determinants of health, vaccine hesitancy, and historical exclusion in clinical trials. This paper primarily focuses on human papillomavirus (HPV) and potential vaccines for Native Americans. However, we also aim to inform researchers on factors that influence Native American choices surrounding vaccination and interventions including cancer therapies. We begin by providing an overview of the historical distrust and trauma Native Americans experience, both past and present. In addition, we offer guidance and considerations when engaging with sovereign Tribal Nations in vaccine development and clinical trials in order to increase trust and encourage vaccine uptake. |
Pearson, Talima; Hepp, Crystal; II, Robert Trotter T; Mbegbu, Mimi; Russakoff, Benjamin; Yagüe, David Panisello; Wood, Colin; Tucker-Morgan, Kara; Ceniceros, Kathya; Padilla, Cristina; Kyman, Shari; Villa, Francisco Genome Sequences of Community Carriage Strains of Staphylococcus aureus from Yuma, Arizona Journal Article Microbiology Resource Announcements, 10 (37), 2021. @article{Pearson2021, title = {Genome Sequences of Community Carriage Strains of Staphylococcus aureus from Yuma, Arizona}, author = {Talima Pearson and Crystal Hepp and Robert T Trotter II and Mimi Mbegbu and Benjamin Russakoff and David Panisello Yagüe and Colin Wood and Kara Tucker-Morgan and Kathya Ceniceros and Cristina Padilla and Shari Kyman and Francisco Villa}, url = {https://journals.asm.org/doi/10.1128/MRA.00449-21}, doi = {10.1128/MRA.00449-21}, year = {2021}, date = {2021-09-16}, journal = {Microbiology Resource Announcements}, volume = {10}, number = {37}, abstract = {Staphylococcus aureus exists as a pathogen and commensal. Individuals with asymptomatic carriage serve as a reservoir for transmission and are at increased risk of infecting themselves. In order to characterize the genomic diversity of S. aureus circulating in the community, we sequenced 166 genomes collected from individuals in Yuma, AZ.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Staphylococcus aureus exists as a pathogen and commensal. Individuals with asymptomatic carriage serve as a reservoir for transmission and are at increased risk of infecting themselves. In order to characterize the genomic diversity of S. aureus circulating in the community, we sequenced 166 genomes collected from individuals in Yuma, AZ. |
Ransdell, Lynda B; Wayment, Heidi A; Lopez, Nanette; Lorts, Cori; Schwartz, Anna L; Pugliesi, Karen; Pohl, Patricia S; Bycura, Dierdra; Camplain, Ricky Women, 1 (3), pp. 143-168, 2021. @article{Ransdell2021b, title = {The Impact of Resistance Training on Body Composition, Muscle Strength, and Functional Fitness in Older Women (45–80 Years): A Systematic Review (2010–2020)}, author = {Lynda B. Ransdell and Heidi A. Wayment and Nanette Lopez and Cori Lorts and Anna L. Schwartz and Karen Pugliesi and Patricia S. Pohl and Dierdra Bycura and Ricky Camplain}, url = {https://doi.org/10.3390/women1030014}, doi = {10.3390/women1030014}, year = {2021}, date = {2021-09-14}, journal = {Women}, volume = {1}, number = {3}, pages = {143-168}, abstract = {As women age, they typically experience a progressive decrease in skeletal muscle mass and strength, which can lead to a decline in functional fitness and quality of life. Resistance training (RT) has the potential to attenuate these losses. Although well established for men, evidence regarding the benefits of RT for women is sparse and inconsistent: prior reviews include too few studies with women and do not adequately examine the interactive or additive impacts of workload, modalities, and nutritional supplements on outcomes such as muscle mass (MM), body composition (BC), muscle strength (MS), and functional fitness (FF). The purpose of this review is to identify these gaps. Thirty-eight papers published between 2010 and 2020 (in English) represent 2519 subjects (mean age = 66.89 ± 4.91 years). Intervention averages include 2 to 3 × 50 min sessions across 15 weeks with 7 exercises per session and 11 repetitions per set. Twelve studies (32%) examined the impact of RT plus dietary manipulation. MM, MS, and FF showed positive changes after RT. Adding RT to fitness regimens for peri- to postmenopausal women is likely to have positive benefits.}, keywords = {}, pubstate = {published}, tppubtype = {article} } As women age, they typically experience a progressive decrease in skeletal muscle mass and strength, which can lead to a decline in functional fitness and quality of life. Resistance training (RT) has the potential to attenuate these losses. Although well established for men, evidence regarding the benefits of RT for women is sparse and inconsistent: prior reviews include too few studies with women and do not adequately examine the interactive or additive impacts of workload, modalities, and nutritional supplements on outcomes such as muscle mass (MM), body composition (BC), muscle strength (MS), and functional fitness (FF). The purpose of this review is to identify these gaps. Thirty-eight papers published between 2010 and 2020 (in English) represent 2519 subjects (mean age = 66.89 ± 4.91 years). Intervention averages include 2 to 3 × 50 min sessions across 15 weeks with 7 exercises per session and 11 repetitions per set. Twelve studies (32%) examined the impact of RT plus dietary manipulation. MM, MS, and FF showed positive changes after RT. Adding RT to fitness regimens for peri- to postmenopausal women is likely to have positive benefits. |
Teufel-Shone, Nicolette I; Chief, Carmenlita; Richards, Jennifer R; Clausen, Rebecca J; Yazzie, Alfred; Jr, Manley Begay A; Lothrop, Nathan; Yazzie, Janene; Begay, Andria B; Beamer, Paloma I; Chief, Karletta International Journal of Environmental Research and Public Health, 18 (17), pp. 9402, 2021. @article{Teufel-Shone2021, title = {Development of a Culturally Anchored Qualitative Approach to Conduct and Analyze Focus Group Narratives Collected in Diné (Navajo) Communities to Understand the Impacts of the Gold King Mine Spill of 2015}, author = {Nicolette I Teufel-Shone and Carmenlita Chief and Jennifer R Richards and Rebecca J Clausen and Alfred Yazzie and Manley A Begay Jr and Nathan Lothrop and Janene Yazzie and Andria B Begay and Paloma I Beamer and Karletta Chief}, url = { https://doi.org/10.3390/ijerph18179402}, doi = {10.3390/ijerph18179402}, year = {2021}, date = {2021-09-06}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {17}, pages = {9402}, abstract = {The Gold King Mine Spill (Spill) occurred in August 2015 upstream from Silverton, Colorado and released three million gallons of contaminated water into the Animas River, a tributary to the San Juan River that flows across the Navajo Nation. Using principles of community-engaged research, the Gold King Mine Spill Diné Exposure Project co-developed a culturally anchored approach to conduct focus groups and analyze narratives collected in three Diné (Navajo) communities along the San Juan River within 9 months of the Spill. Focus group questions were designed to document the socio-cultural impacts of the Spill. This paper: (1) outlines the partnerships and approvals; (2) describes focus group design, training, data collection and analysis; and (3) reflects on the use of a culturally anchored approach in Indigenous, specifically Diné-centered research. Diné social and cultural etiquette and concepts of relationality were used to adapt standard (non-Indigenous) qualitative methods. Findings describe community perceptions of short-term impacts of the disaster, as well as past and present injustices, communication related to the Spill, and concerns of persistent threats to Diné lifeways. The culturally anchored approach was critical in fostering trust with Diné participants and aligned with the candor of the discussions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Gold King Mine Spill (Spill) occurred in August 2015 upstream from Silverton, Colorado and released three million gallons of contaminated water into the Animas River, a tributary to the San Juan River that flows across the Navajo Nation. Using principles of community-engaged research, the Gold King Mine Spill Diné Exposure Project co-developed a culturally anchored approach to conduct focus groups and analyze narratives collected in three Diné (Navajo) communities along the San Juan River within 9 months of the Spill. Focus group questions were designed to document the socio-cultural impacts of the Spill. This paper: (1) outlines the partnerships and approvals; (2) describes focus group design, training, data collection and analysis; and (3) reflects on the use of a culturally anchored approach in Indigenous, specifically Diné-centered research. Diné social and cultural etiquette and concepts of relationality were used to adapt standard (non-Indigenous) qualitative methods. Findings describe community perceptions of short-term impacts of the disaster, as well as past and present injustices, communication related to the Spill, and concerns of persistent threats to Diné lifeways. The culturally anchored approach was critical in fostering trust with Diné participants and aligned with the candor of the discussions. |
Credo, Jonathan; Ingram, Jani C Perspective Developing Successful Collaborative Research Partnerships with AI/AN Communities Journal Article International Journal of Environmental Research and Public Health, 18 (17), pp. 9089, 2021. @article{Credo2021, title = {Perspective Developing Successful Collaborative Research Partnerships with AI/AN Communities}, author = {Jonathan Credo and Jani C Ingram}, url = {https://pubmed.ncbi.nlm.nih.gov/34501677/}, doi = {10.3390/ijerph18179089}, year = {2021}, date = {2021-08-28}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {17}, pages = {9089}, abstract = {In the United States, American Indian and Alaska Native (AI/AN) people are frequently under- or misrepresented in research and health statistics. A principal reason for this disparity is the lack of collaborative partnerships between researchers and tribes. There are hesitations from both academic Western scientists and tribal communities to establish new partnerships due to differences in cultural and scientific understanding, from data ownership and privacy to dissemination and project expansion. An infamous example is the mishandling of samples collected from the Havasupai Tribe by Arizona State University (ASU) scientists, leading to a legal battle between the tribe and ASU and ending in a moratorium of research with the Havasupai people. This paper will explore three successful and positive collaborations with a large and small tribe, including how the partnerships were established and the outcomes of the collaboration. In addition, the paper will provide perspective of what needs to be addressed by Western scientists if productive collaborations with tribal groups are to be established.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In the United States, American Indian and Alaska Native (AI/AN) people are frequently under- or misrepresented in research and health statistics. A principal reason for this disparity is the lack of collaborative partnerships between researchers and tribes. There are hesitations from both academic Western scientists and tribal communities to establish new partnerships due to differences in cultural and scientific understanding, from data ownership and privacy to dissemination and project expansion. An infamous example is the mishandling of samples collected from the Havasupai Tribe by Arizona State University (ASU) scientists, leading to a legal battle between the tribe and ASU and ending in a moratorium of research with the Havasupai people. This paper will explore three successful and positive collaborations with a large and small tribe, including how the partnerships were established and the outcomes of the collaboration. In addition, the paper will provide perspective of what needs to be addressed by Western scientists if productive collaborations with tribal groups are to be established. |
Ransdell, Lynda B; Wayment, Heidi A; Schwartz, Anna L; Lane, Taylor S; Baldwin, Julie A Precision mentoring (PM): a proposed framework for increasing research capacity in health-related disciplines Journal Article Medical Education Online, 2021. @article{Ransdell2021c, title = {Precision mentoring (PM): a proposed framework for increasing research capacity in health-related disciplines}, author = {Lynda B Ransdell and Heidi A Wayment and Anna L Schwartz and Taylor S Lane and Julie A Baldwin}, url = {https://www.tandfonline.com/doi/full/10.1080/10872981.2021.1964933}, doi = {10.1080/10872981.2021.1964933}, year = {2021}, date = {2021-08-24}, journal = {Medical Education Online}, abstract = {Research productivity is expected of academic faculty, and mentoring can facilitate it. This paper presents a framework for using mentoring to develop researchers in health disciplines. We utilized recent literature reviews, and experience developing researchers at an emerging research institution within the Research Centers for Minority Institutions (RCMI) program, to propose a precision mentoring (PM) framework for research development. Although we cannot precisely determine how much improvement was due to the PM framework, over the 4 years of our program, the quality and quantity of pilot project proposals (PPP) has increased, the number of external proposals submitted and funded by PPP investigators has increased, and the number of faculty participating in our program has increased. Surveys distributed to our 2021–22 PPP applicants who did not receive funding (n = 5/6 or 86.7%) revealed that new investigators most frequently sought mentoring related to career guidance (e.g., institutional culture, pre-tenure survival strategies), grant proposal basics (e.g., working with funding agencies, reviewing aims, balancing priorities, and enhancing scientific rigor), and identifying funding opportunities.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Research productivity is expected of academic faculty, and mentoring can facilitate it. This paper presents a framework for using mentoring to develop researchers in health disciplines. We utilized recent literature reviews, and experience developing researchers at an emerging research institution within the Research Centers for Minority Institutions (RCMI) program, to propose a precision mentoring (PM) framework for research development. Although we cannot precisely determine how much improvement was due to the PM framework, over the 4 years of our program, the quality and quantity of pilot project proposals (PPP) has increased, the number of external proposals submitted and funded by PPP investigators has increased, and the number of faculty participating in our program has increased. Surveys distributed to our 2021–22 PPP applicants who did not receive funding (n = 5/6 or 86.7%) revealed that new investigators most frequently sought mentoring related to career guidance (e.g., institutional culture, pre-tenure survival strategies), grant proposal basics (e.g., working with funding agencies, reviewing aims, balancing priorities, and enhancing scientific rigor), and identifying funding opportunities. |
Trotter, Robert; Baldwin, Julie A; Buck, Charles Loren; Remiker, Mark; Aguirre, Amanda; Milner, Trudie; Torres, Emma; von Hippel, Frank Arthur JMIR Research Protocol, 10 (8), 2021. @article{Trotter2021, title = {Health Impacts of Perchlorate and Pesticide Exposure: Protocol for Community-Engaged Research to Evaluate Environmental Toxicants in a US Border Community}, author = {Robert Trotter and Julie A Baldwin and Charles Loren Buck and Mark Remiker and Amanda Aguirre and Trudie Milner and Emma Torres and Frank Arthur von Hippel}, url = {https://pubmed.ncbi.nlm.nih.gov/34383679/}, doi = {10.2196/15864}, year = {2021}, date = {2021-08-11}, journal = {JMIR Research Protocol}, volume = {10}, number = {8}, abstract = {The Northern Arizona University (NAU) Center for Health Equity Research (CHER) is conducting community-engaged health research involving "environmental scans" in Yuma County in collaboration with community health stakeholders, including the Yuma Regional Medical Center (YRMC), Regional Center for Border Health, Inc. (RCBH), Campesinos Sin Fronteras (CSF), Yuma County Public Health District, and government agencies and nongovernmental organizations (NGOs) working on border health issues. The purpose of these efforts is to address community-generated environmental health hazards identified through ongoing coalitions among NAU, and local health care and research institutions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The Northern Arizona University (NAU) Center for Health Equity Research (CHER) is conducting community-engaged health research involving "environmental scans" in Yuma County in collaboration with community health stakeholders, including the Yuma Regional Medical Center (YRMC), Regional Center for Border Health, Inc. (RCBH), Campesinos Sin Fronteras (CSF), Yuma County Public Health District, and government agencies and nongovernmental organizations (NGOs) working on border health issues. The purpose of these efforts is to address community-generated environmental health hazards identified through ongoing coalitions among NAU, and local health care and research institutions. |
Schwartz, Anna L; Terry, Christopher M Returning to Sport: Female Athletes Living with and beyond Cancer Journal Article International Journal of Environmental Research and Public Health, 18 (15), 2021. @article{Schwartz2021, title = {Returning to Sport: Female Athletes Living with and beyond Cancer}, author = {Anna L. Schwartz and Christopher M. Terry}, url = {https://doi.org/10.3390/ijerph18158151}, doi = {10.3390/ijerph18158151}, year = {2021}, date = {2021-08-01}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {15}, abstract = {Many athletes living with and beyond cancer can continue to train and, in some cases, compete during treatment. Following cancer treatment, athletes can return to competitive sport but need to learn to adapt their physical strength and training to the lingering effects of cancer. It is critical for oncology healthcare providers to use the principles of assess, refer and advise to exercise oncology programs that are appropriate for the individual. Managing side effects of treatment is key to being able to train during and immediately following cancer treatment. Keen attention to fatigue is important at any point in the cancer spectrum to avoid overtraining and optimize the effects of training. Resources are introduced for providers to reference and direct patients to information for psychosocial support and instruction. The purpose of this paper is to present exercise considerations during and after cancer treatment for athletic cancer survivors.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Many athletes living with and beyond cancer can continue to train and, in some cases, compete during treatment. Following cancer treatment, athletes can return to competitive sport but need to learn to adapt their physical strength and training to the lingering effects of cancer. It is critical for oncology healthcare providers to use the principles of assess, refer and advise to exercise oncology programs that are appropriate for the individual. Managing side effects of treatment is key to being able to train during and immediately following cancer treatment. Keen attention to fatigue is important at any point in the cancer spectrum to avoid overtraining and optimize the effects of training. Resources are introduced for providers to reference and direct patients to information for psychosocial support and instruction. The purpose of this paper is to present exercise considerations during and after cancer treatment for athletic cancer survivors. |
Hardy, Lisa J; Mana, Adi; Mundell, Leah; Benheim, Sharón; Morales, Kayla Torres; Sagy, Shifra Living in opposition: How women in the United States cope in spite of mistrust of federal leadership during the pandemic of Covid-19 Journal Article Journal of Community Psychology, 49 (6), pp. 2059-2070, 2021, ISBN: 10.1002/jcop.22544. @article{Hardy2021, title = {Living in opposition: How women in the United States cope in spite of mistrust of federal leadership during the pandemic of Covid-19}, author = {Lisa J Hardy and Adi Mana and Leah Mundell and Sharón Benheim and Kayla Torres Morales and Shifra Sagy}, url = {https://pubmed.ncbi.nlm.nih.gov/33729586/}, doi = {10.1002/jcop.22544}, isbn = {10.1002/jcop.22544}, year = {2021}, date = {2021-08-01}, journal = {Journal of Community Psychology}, volume = {49}, number = {6}, pages = {2059-2070}, abstract = {International research collaborators conducted research investigating sociocultural responses to the Covid-19 pandemic. Our mixed methods research design includes surveys and interviews conducted between March and September of 2020 including 249 of 506 survey responses and 18 of 50 in-depth, exploratory, semi-structured interviews with self-defined politically left-leaning women in the United States. We employ a sequential design to analyze statistical and qualitative data. Despite international data suggesting that trust in federal governments reduces anxiety, women who did not trust and actively opposed the Trump administration reported lower levels of anxiety than expected. Results indicate reliance on and development of new forms of connection that seem to mitigate symptomatic anxieties when living in opposition. Women living in opposition to the leadership of the federal government use and develop resources to help them cope. Research on coping strategies and mental health and anxiety during crisis can inform recommendations for ways to support and strengthen sense of coherence during tumultuous times.}, keywords = {}, pubstate = {published}, tppubtype = {article} } International research collaborators conducted research investigating sociocultural responses to the Covid-19 pandemic. Our mixed methods research design includes surveys and interviews conducted between March and September of 2020 including 249 of 506 survey responses and 18 of 50 in-depth, exploratory, semi-structured interviews with self-defined politically left-leaning women in the United States. We employ a sequential design to analyze statistical and qualitative data. Despite international data suggesting that trust in federal governments reduces anxiety, women who did not trust and actively opposed the Trump administration reported lower levels of anxiety than expected. Results indicate reliance on and development of new forms of connection that seem to mitigate symptomatic anxieties when living in opposition. Women living in opposition to the leadership of the federal government use and develop resources to help them cope. Research on coping strategies and mental health and anxiety during crisis can inform recommendations for ways to support and strengthen sense of coherence during tumultuous times. |
Tippens, Julie A; Hatton-Bowers, Holly; Honomichl, Ryan; Wheeler, Lorey A; Miamidian, Helen M; Bash, Kirstie L; Smith, Michelle Howell C; Nyaoro, Dulo; Byrd, Joshua J; Packard, Samuel E; Teufel-Shone, Nicolette I Psychological distress prevalence and associated stressors and supports among urban-displaced Congolese adults in Kenya Journal Article American Journal of Orthopsychiatry, 91 (5), pp. 626–634, 2021. @article{Tippens2021, title = {Psychological distress prevalence and associated stressors and supports among urban-displaced Congolese adults in Kenya}, author = {Julie A. Tippens and Holly Hatton-Bowers and Ryan Honomichl and Lorey A. Wheeler and Helen M. Miamidian and Kirstie L. Bash and Michelle C. Howell Smith and Dulo Nyaoro and Joshua J Byrd and Samuel E. Packard and Nicolette I. Teufel-Shone}, url = {https://doi.org/10.1037/ort0000564}, doi = {10.1037/ort0000564}, year = {2021}, date = {2021-07-01}, journal = {American Journal of Orthopsychiatry}, volume = {91}, number = {5}, pages = {626–634}, abstract = {There is limited understanding of the prevalence of psychological distress and associated stressors and supports among displaced adults in low- and middle-income first asylum countries. Method: This article reports the findings of a cross-sectional study. We recruited 245 Congolese adults (18–80 years) residing in Nairobi, Kenya using snowball sampling. Data were collected using an interviewer-administered questionnaire consisting of sociodemographic characteristics, the Self-Reporting Questionnaire (SRQ-20), and a locally developed stressors and supports survey. We used multivariable logistic regression to examine associations among sociodemographic, stressor, and support variables and the likelihood of experiencing psychological distress. Results: More than half of the participants (52.8%) reported symptoms indicative of psychological distress. Factors associated with increased psychological distress included perceiving to have a useful role in one’s family or community, AOR = 1.85; 95% CI [1.1.17, 3.11], p = .012, feeling confused or not knowing what to do, AOR = 2.13; 95% CI [1.20, 4.6], p = .014, and feeling afraid to leave home for medical/health care to help with an illness, AOR = 1.57; 95% CI [1.17, 2.15], p < .01. Additionally, ethnic Banyamulenge Congolese adults without legal refugee status had an increased likelihood of experiencing psychological distress, AOR = .07; 95% CI [0, .74], p = .035. Conclusion: Future research is warranted to understand how to implement targeted mental health and psychosocial support (MHPSS) to improve urban-displaced adults’ sense of safety and belonging. Our findings suggest that legal refugee status is an important structural determinant of mental health, which should be considered in MHPSS practice and policy.}, keywords = {}, pubstate = {published}, tppubtype = {article} } There is limited understanding of the prevalence of psychological distress and associated stressors and supports among displaced adults in low- and middle-income first asylum countries. Method: This article reports the findings of a cross-sectional study. We recruited 245 Congolese adults (18–80 years) residing in Nairobi, Kenya using snowball sampling. Data were collected using an interviewer-administered questionnaire consisting of sociodemographic characteristics, the Self-Reporting Questionnaire (SRQ-20), and a locally developed stressors and supports survey. We used multivariable logistic regression to examine associations among sociodemographic, stressor, and support variables and the likelihood of experiencing psychological distress. Results: More than half of the participants (52.8%) reported symptoms indicative of psychological distress. Factors associated with increased psychological distress included perceiving to have a useful role in one’s family or community, AOR = 1.85; 95% CI [1.1.17, 3.11], p = .012, feeling confused or not knowing what to do, AOR = 2.13; 95% CI [1.20, 4.6], p = .014, and feeling afraid to leave home for medical/health care to help with an illness, AOR = 1.57; 95% CI [1.17, 2.15], p < .01. Additionally, ethnic Banyamulenge Congolese adults without legal refugee status had an increased likelihood of experiencing psychological distress, AOR = .07; 95% CI [0, .74], p = .035. Conclusion: Future research is warranted to understand how to implement targeted mental health and psychosocial support (MHPSS) to improve urban-displaced adults’ sense of safety and belonging. Our findings suggest that legal refugee status is an important structural determinant of mental health, which should be considered in MHPSS practice and policy. |
Camplain, Ricky; Lininger, Monica R; Baldwin, Julie A; II, Robert Trotter T Cardiovascular Risk Factors among Individuals Incarcerated in an Arizona County Jail Journal Article International Journal of Environmental Research and Public Health, 18 (13), 2021. @article{Camplain2021, title = {Cardiovascular Risk Factors among Individuals Incarcerated in an Arizona County Jail}, author = {Ricky Camplain and Monica R. Lininger and Julie A. Baldwin and Robert T. Trotter II}, url = {https://doi.org/10.3390/ijerph18137007}, doi = {10.3390/ijerph18137007}, year = {2021}, date = {2021-06-30}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {13}, abstract = {We aimed to estimate the prevalence of cardiovascular risk factors, including hypertension, diabetes, high cholesterol, cigarette smoking, alcohol consumption, and obesity among a sample of individuals incarcerated in an Arizona county jail and compare prevalence estimates to a matched non-institutionalized population. From 2017–2018, individuals housed at a county jail completed a cross-sectional health survey. We estimated the prevalence of hypertension, diabetes, cholesterol, overweight/obesity, cigarette smoking, binge drinking, and self-reported health among individuals incarcerated. We compared prevalence estimates of cardiovascular risk factors to a matched sample of 2017–2018 NHANES participants. Overall, 35.9%, 7.7%, and 17.8% of individuals incarcerated in jail self-reported hypertension, diabetes, and high cholesterol, respectively. Of individuals incarcerated, 59.6% were overweight or obese and 36.8% self-reported fair or poor general health. Over half of individuals incarcerated reported ever smoking cigarettes (72.3%) and binge drinking (60.7%). Compared to a matched sample of NHANES participants, individuals incarcerated in jail had a statistically higher prevalence of cigarette smoking and binge drinking. Screening of cardiovascular risk factors and providing preventive measures and interventions, such as healthy eating, physical activity, or pharmacological adherence interventions, while individuals are incarcerated may contribute to the prevention and management of cardiovascular risk factors and, eventually, cardiovascular disease.}, keywords = {}, pubstate = {published}, tppubtype = {article} } We aimed to estimate the prevalence of cardiovascular risk factors, including hypertension, diabetes, high cholesterol, cigarette smoking, alcohol consumption, and obesity among a sample of individuals incarcerated in an Arizona county jail and compare prevalence estimates to a matched non-institutionalized population. From 2017–2018, individuals housed at a county jail completed a cross-sectional health survey. We estimated the prevalence of hypertension, diabetes, cholesterol, overweight/obesity, cigarette smoking, binge drinking, and self-reported health among individuals incarcerated. We compared prevalence estimates of cardiovascular risk factors to a matched sample of 2017–2018 NHANES participants. Overall, 35.9%, 7.7%, and 17.8% of individuals incarcerated in jail self-reported hypertension, diabetes, and high cholesterol, respectively. Of individuals incarcerated, 59.6% were overweight or obese and 36.8% self-reported fair or poor general health. Over half of individuals incarcerated reported ever smoking cigarettes (72.3%) and binge drinking (60.7%). Compared to a matched sample of NHANES participants, individuals incarcerated in jail had a statistically higher prevalence of cigarette smoking and binge drinking. Screening of cardiovascular risk factors and providing preventive measures and interventions, such as healthy eating, physical activity, or pharmacological adherence interventions, while individuals are incarcerated may contribute to the prevention and management of cardiovascular risk factors and, eventually, cardiovascular disease. |
Akintobi, Tabia Henry; Sheikhattari, Payam; Shaffer, Emma; Evans, Christina L; Braun, Kathryn L; Sy, Angela U; Mancera, Bibiana; Campa, Adriana; Miller, Stephania T; Sarpong, Daniel; Holliday, Rhonda; Jimenez-Chavez, Julio; Khan, Shafiq; Hinton, Cimona; Sellars-Bates, Kimberly; Ajewole, Veronica; Teufel-Shone, Nicolette I International Journal of Environmental Research and Public Health, 18 (12), 2021. @article{Akintobi2021, title = {Community Engagement Practices at Research Centers in U.S. Minority Institutions: Priority Populations and Innovative Approaches to Advancing Health Disparities Research}, author = {Tabia Henry Akintobi and Payam Sheikhattari and Emma Shaffer and Christina L. Evans and Kathryn L. Braun and Angela U. Sy and Bibiana Mancera and Adriana Campa and Stephania T. Miller and Daniel Sarpong and Rhonda Holliday and Julio Jimenez-Chavez and Shafiq Khan and Cimona Hinton and Kimberly Sellars-Bates and Veronica Ajewole and Nicolette I. Teufel-Shone}, url = {https://doi.org/10.3390/ijerph18126675}, doi = {10.3390/ijerph18126675}, year = {2021}, date = {2021-06-21}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {12}, abstract = {This paper details U.S. Research Centers in Minority Institutions (RCMI) Community Engagement Cores (CECs): (1) unique and cross-cutting components, focus areas, specific aims, and target populations; and (2) approaches utilized to build or sustain trust towards community participation in research. A mixed-method data collection approach was employed for this cross-sectional study of current or previously funded RCMIs. A total of 18 of the 25 institutions spanning 13 U.S. states and territories participated. CEC specific aims were to support community engaged research (94%); to translate and disseminate research findings (88%); to develop partnerships (82%); and to build capacity around community research (71%). Four open-ended questions, qualitative analysis, and comparison of the categories led to the emergence of two supporting themes: (1) establishing trust between the community-academic collaborators and within the community and (2) building collaborative relationships. An overarching theme, building community together through trust and meaningful collaborations, emerged from the supporting themes and subthemes. The RCMI institutions and their CECs serve as models to circumvent the historical and current challenges to research in communities disproportionately affected by health disparities. Lessons learned from these cores may help other institutions who want to build community trust in and capacities for research that addresses community-related health concerns.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This paper details U.S. Research Centers in Minority Institutions (RCMI) Community Engagement Cores (CECs): (1) unique and cross-cutting components, focus areas, specific aims, and target populations; and (2) approaches utilized to build or sustain trust towards community participation in research. A mixed-method data collection approach was employed for this cross-sectional study of current or previously funded RCMIs. A total of 18 of the 25 institutions spanning 13 U.S. states and territories participated. CEC specific aims were to support community engaged research (94%); to translate and disseminate research findings (88%); to develop partnerships (82%); and to build capacity around community research (71%). Four open-ended questions, qualitative analysis, and comparison of the categories led to the emergence of two supporting themes: (1) establishing trust between the community-academic collaborators and within the community and (2) building collaborative relationships. An overarching theme, building community together through trust and meaningful collaborations, emerged from the supporting themes and subthemes. The RCMI institutions and their CECs serve as models to circumvent the historical and current challenges to research in communities disproportionately affected by health disparities. Lessons learned from these cores may help other institutions who want to build community trust in and capacities for research that addresses community-related health concerns. |
Jones, Christopher W; Morales, Crystal G; Eltiste, Sharon L; Yanchik-Slade, Francine E; Lee, Naomi R; Nilsson, Bradley L Capacity for increased surface area in the hydrophobic core of β-sheet peptide bilayer nanoribbons Journal Article Journal of Peptide Science, 27 , 2021. @article{Jones2021, title = {Capacity for increased surface area in the hydrophobic core of β-sheet peptide bilayer nanoribbons}, author = {Christopher W. Jones and Crystal G. Morales and Sharon L. Eltiste and Francine E. Yanchik-Slade and Naomi R. Lee and Bradley L. Nilsson}, url = {https://doi.org/10.1002/psc.3334}, doi = {10.1002/psc.3334}, year = {2021}, date = {2021-06-20}, journal = {Journal of Peptide Science}, volume = {27}, abstract = {Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE)2-NH2 peptides (X = hydrophobic residue). A series of Ac-(XKXE)2-NH2 peptides incorporating aromatic amino acids of increasing molecular volume and steric profile (X = phenylalanine [Phe], homophenylalanine [Hph], tryptophan [Trp], 1-naphthylalanine [1-Nal], 2-naphthylalanine [2-Nal], or biphenylalanine [Bip]) were assessed to determine substitution effects on self-assembly propensity and on morphology of the resulting nanoribbon structures. Additional studies were conducted to determine the effects of incorporating amino acids of differing steric profile in the hydrophobic core (Ac-X1KFEFKFE-NH2 and Ac-(X1,5KFE)-NH2 peptides, X = Trp or Bip). Spectroscopic analysis by circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy indicated β-sheet formation for all variants. Self-assembly rate increased with peptide hydrophobicity; increased molecular volume of the hydrophobic side chain groups did not appear to induce kinetic penalties on self-assembly rates. Transmission electron microscopy (TEM) imaging indicated variation in fibril morphology as a function of amino acid in the X positions. This study confirms that hydrophobicity of amphipathic Ac-(XKXE)2-NH2 peptides correlates to self-assembly propensity and that the hydrophobic core of the resulting nanoribbon bilayers has a significant capacity to accommodate sterically demanding functional groups. These findings provide insight that may be used to guide the exploitation of self-assembled amphipathic peptides as functional biomaterials. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE)2-NH2 peptides (X = hydrophobic residue). A series of Ac-(XKXE)2-NH2 peptides incorporating aromatic amino acids of increasing molecular volume and steric profile (X = phenylalanine [Phe], homophenylalanine [Hph], tryptophan [Trp], 1-naphthylalanine [1-Nal], 2-naphthylalanine [2-Nal], or biphenylalanine [Bip]) were assessed to determine substitution effects on self-assembly propensity and on morphology of the resulting nanoribbon structures. Additional studies were conducted to determine the effects of incorporating amino acids of differing steric profile in the hydrophobic core (Ac-X1KFEFKFE-NH2 and Ac-(X1,5KFE)-NH2 peptides, X = Trp or Bip). Spectroscopic analysis by circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy indicated β-sheet formation for all variants. Self-assembly rate increased with peptide hydrophobicity; increased molecular volume of the hydrophobic side chain groups did not appear to induce kinetic penalties on self-assembly rates. Transmission electron microscopy (TEM) imaging indicated variation in fibril morphology as a function of amino acid in the X positions. This study confirms that hydrophobicity of amphipathic Ac-(XKXE)2-NH2 peptides correlates to self-assembly propensity and that the hydrophobic core of the resulting nanoribbon bilayers has a significant capacity to accommodate sterically demanding functional groups. These findings provide insight that may be used to guide the exploitation of self-assembled amphipathic peptides as functional biomaterials. |
Eaves, Emery R; Barber, Jarrett; Whealy, Ryann; Clancey, Sara A; Wright, Rita; Cocking, Jill Hager; Spadafino, Joseph; Hepp, Crystal M Characterization of neonatal opioid withdrawal syndrome in Arizona from 2010-2017 Journal Article PLOS ONE, 16 (6), 2021. @article{Eaves2021, title = {Characterization of neonatal opioid withdrawal syndrome in Arizona from 2010-2017}, author = {Emery R. Eaves and Jarrett Barber and Ryann Whealy and Sara A. Clancey and Rita Wright and Jill Hager Cocking and Joseph Spadafino and Crystal M. Hepp }, url = {https://doi.org/10.1371/journal.pone.0248476}, doi = {10.1371/journal.pone.0248476}, year = {2021}, date = {2021-06-03}, journal = {PLOS ONE}, volume = {16}, number = {6}, abstract = {In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported. }, keywords = {}, pubstate = {published}, tppubtype = {article} } In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported. |
Abdul-Chani, Monical; Moreno, Christopher P; Reeder, Julia A; Zuckerman, Katherine; Lindly, Olivia Perceived community disability stigma in multicultural, low-income populations: Measure development and validation Journal Article Research in Developmental Disabilities, 115 , 2021. @article{Abdul-Chani2021, title = {Perceived community disability stigma in multicultural, low-income populations: Measure development and validation}, author = {Monical Abdul-Chani and Christopher P Moreno and Julia A Reeder and Katherine Zuckerman and Olivia Lindly}, url = {https://doi.org/10.1016/j.ridd.2021.103997}, doi = {10.1016/j.ridd.2021.103997}, year = {2021}, date = {2021-05-29}, journal = {Research in Developmental Disabilities}, volume = {115}, abstract = {Stigma and knowledge about disabilities differ across groups, impacting care. No validated measures of perceived community disability stigma exist for families in multicultural communities, at risk for disparities.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Stigma and knowledge about disabilities differ across groups, impacting care. No validated measures of perceived community disability stigma exist for families in multicultural communities, at risk for disparities. |
Kumar, Amit; Roy, Indrakshi; Karmarkar, Amol M; Erler, Kimberly S; Rudolph, James L; Baldwin, Julie A Shifting US Patterns of COVID-19 Mortality by Race and Ethnicity From June-December 2020 Journal Article Journal of American Medical Direct Association, 22 (5), pp. 966-970, 2021. @article{Kumar2021b, title = {Shifting US Patterns of COVID-19 Mortality by Race and Ethnicity From June-December 2020}, author = {Amit Kumar and Indrakshi Roy and Amol M Karmarkar and Kimberly S Erler and James L Rudolph and Julie A Baldwin}, url = {https://www.sciencedirect.com/science/article/abs/pii/S1525861021002553?via%3Dihub}, doi = {10.1016/j.jamda.2021.02.034}, year = {2021}, date = {2021-05-05}, journal = {Journal of American Medical Direct Association}, volume = {22}, number = {5}, pages = {966-970}, abstract = {The COVID-19 pandemic has disproportionately affected racial and ethnic minorities in the United States and has been devastating for residents of nursing homes (NHs). However, evidence on racial and ethnic disparities in COVID-19-related mortality rates within NHs and how that has changed over time has been limited. This study examines the impact of a high proportion of minority residents in NHs on COVID-19-related mortality rates over a 30-week period.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The COVID-19 pandemic has disproportionately affected racial and ethnic minorities in the United States and has been devastating for residents of nursing homes (NHs). However, evidence on racial and ethnic disparities in COVID-19-related mortality rates within NHs and how that has changed over time has been limited. This study examines the impact of a high proportion of minority residents in NHs on COVID-19-related mortality rates over a 30-week period. |
Pro, George; Schumacher, Krista; Hubach, Randolph; Zaller, Nickolas; Giano, Zachary; Camplain, Ricky; Camplain, Carolyn; Haberstroh, Shane; Baldwin, Julie A; Wheeler, Denna L US trends in mask wearing during the COVID-19 pandemic depend on rurality Journal Article Rural and Remote Health, 21 , 2021. @article{Pro2021, title = {US trends in mask wearing during the COVID-19 pandemic depend on rurality}, author = {George Pro and Krista Schumacher and Randolph Hubach and Nickolas Zaller and Zachary Giano and Ricky Camplain and Carolyn Camplain and Shane Haberstroh and Julie A Baldwin and Denna L Wheeler}, url = {https://doi.org/10.22605/RRH6596}, doi = {10.22605/RRH6596}, year = {2021}, date = {2021-05-04}, journal = {Rural and Remote Health}, volume = {21}, abstract = {Face masks are widely recommended as a COVID-19 prevention strategy. State mask mandates have generally reduced the spread of the disease, but decisions to wear a mask depend on many factors. Recent increases in case rates in rural areas following initial outbreaks in more densely populated areas highlight the need to focus on prevention and education. Messaging about disease risk has faced challenges in rural areas in the past. While surges in cases within some communities are likely an impetus for behavior change, rising case rates likely explain only part of mask-wearing decisions. The current study examined the relationship between county-level indicators of rurality and mask wearing in the USA. National data from the New York Times’ COVID-19 cross-sectional mask survey was used to identify the percentage of a county’s residents who reported always/frequently wearing a mask (2–14 July 2020). The New York Times’ COVID-19 data repository was used to calculate county-level daily case rates for the 2 weeks preceding the mask survey (15 June – 1 July 2020), and defined county rurality using the Index of Relative Rurality (n=3103 counties). Multivariate linear regression was used to predict mask wearing across levels of rurality. The model was adjusted for daily case rates and other relevant county-level confounders, including county-level indicators of age, race/ethnicity, gender, political partisanship, income inequality, and whether each county was subject to a statewide mask mandate. Large clusters of counties with high rurality and low mask wearing were observed in the Midwest, upper Midwest, and mountainous West. Holding daily case rates and other county characteristics constant, the predicted probability of wearing a mask decreased significantly as counties became more rural (β=–0.560; p<0.0001). Conclusion: Upticks in COVID-19 cases and deaths in rural areas are expected to continue, and localized outbreaks will likely occur indefinitely. The present findings highlight the need to better understand the mechanisms underlying perceptions of COVID-19 risk in rural areas. Dissemination of scientifically correct and consistent information is critical during national emergencies.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Face masks are widely recommended as a COVID-19 prevention strategy. State mask mandates have generally reduced the spread of the disease, but decisions to wear a mask depend on many factors. Recent increases in case rates in rural areas following initial outbreaks in more densely populated areas highlight the need to focus on prevention and education. Messaging about disease risk has faced challenges in rural areas in the past. While surges in cases within some communities are likely an impetus for behavior change, rising case rates likely explain only part of mask-wearing decisions. The current study examined the relationship between county-level indicators of rurality and mask wearing in the USA. National data from the New York Times’ COVID-19 cross-sectional mask survey was used to identify the percentage of a county’s residents who reported always/frequently wearing a mask (2–14 July 2020). The New York Times’ COVID-19 data repository was used to calculate county-level daily case rates for the 2 weeks preceding the mask survey (15 June – 1 July 2020), and defined county rurality using the Index of Relative Rurality (n=3103 counties). Multivariate linear regression was used to predict mask wearing across levels of rurality. The model was adjusted for daily case rates and other relevant county-level confounders, including county-level indicators of age, race/ethnicity, gender, political partisanship, income inequality, and whether each county was subject to a statewide mask mandate. Large clusters of counties with high rurality and low mask wearing were observed in the Midwest, upper Midwest, and mountainous West. Holding daily case rates and other county characteristics constant, the predicted probability of wearing a mask decreased significantly as counties became more rural (β=–0.560; p<0.0001). Conclusion: Upticks in COVID-19 cases and deaths in rural areas are expected to continue, and localized outbreaks will likely occur indefinitely. The present findings highlight the need to better understand the mechanisms underlying perceptions of COVID-19 risk in rural areas. Dissemination of scientifically correct and consistent information is critical during national emergencies. |
Lane, Taylor S; Sonderegger, Derek L; Holeva-Eklund, Whitney M; Brazendale, Keith; K.Behrens, Timothy; Howdeshell, Hiliary; Walka, Sherry; R.Cook, Jon; Heer, Hendrik D.de Seasonal Variability in Weight Gain Among American Indian, Black, White, and Hispanic Children: A 3.5-Year Study Journal Article American Journal of Preventive Medicine, 60 (5), pp. 658-665, 2021. @article{Lane2021, title = {Seasonal Variability in Weight Gain Among American Indian, Black, White, and Hispanic Children: A 3.5-Year Study}, author = {Taylor S. Lane and Derek L. Sonderegger and Whitney M. Holeva-Eklund and Keith Brazendale and Timothy K.Behrens and Hiliary Howdeshell and Sherry Walka and Jon R.Cook and Hendrik D.de Heer}, url = {https://doi.org/10.1016/j.amepre.2020.12.010}, doi = {10.1016/j.amepre.2020.12.010}, year = {2021}, date = {2021-05-01}, journal = {American Journal of Preventive Medicine}, volume = {60}, number = {5}, pages = {658-665}, abstract = {Several studies have reported that children gain more weight during the summer season. Despite high obesity rates, little research has included American Indian/Alaskan Native children, and few studies have been longitudinal. This observational study examines seasonal weight variability over 3.5 years among ethnically diverse children, including 2,184 American Indian/Alaskan Native children. Children gained significantly more weight during the summer season, with the strongest effects for children who were obese. American Indian/Alaskan Native children had less seasonal variability than White children, but higher overall obesity rates. These data underscore summer as a critical time for obesity prevention among children who are overweight/obese but suggest that seasonal patterns may vary for American Indian/Alaskan Native children.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Several studies have reported that children gain more weight during the summer season. Despite high obesity rates, little research has included American Indian/Alaskan Native children, and few studies have been longitudinal. This observational study examines seasonal weight variability over 3.5 years among ethnically diverse children, including 2,184 American Indian/Alaskan Native children. Children gained significantly more weight during the summer season, with the strongest effects for children who were obese. American Indian/Alaskan Native children had less seasonal variability than White children, but higher overall obesity rates. These data underscore summer as a critical time for obesity prevention among children who are overweight/obese but suggest that seasonal patterns may vary for American Indian/Alaskan Native children. |
Camplain, Ricky; Lopez, Nanette V; Cooper, Dan M; McKenzie, Thomas L; Zheng, Kai; Radom-Aizik, Shlomit Development of the systematic observation of COVID-19 mitigation (SOCOM): Assessing face covering and distancing in schools Journal Article Journal of Clinical and Translational Science, 5 (1), 2021. @article{Camplain2021b, title = {Development of the systematic observation of COVID-19 mitigation (SOCOM): Assessing face covering and distancing in schools}, author = {Ricky Camplain and Nanette V. Lopez and Dan M. Cooper and Thomas L. McKenzie and Kai Zheng and Shlomit Radom-Aizik}, url = {https://doi.org/10.1017/cts.2021.786}, doi = {10.1017/cts.2021.786}, year = {2021}, date = {2021-04-30}, journal = {Journal of Clinical and Translational Science}, volume = {5}, number = {1}, abstract = {During the COVID-19 pandemic, some K-12 schools resumed in-person classes with varying degrees of mitigation plans in the fall 2020. Physical distancing and face coverings can minimize SARS-CoV-2 spread, the virus that causes COVID-19. However, no research has focused on adherence to mitigation strategies during school days. Thus, we sought to develop a systematic observation protocol to capture COVID-19 mitigation strategy adherence in school environments: The Systematic Observation of COVID-19 Mitigation (SOCOM).}, keywords = {}, pubstate = {published}, tppubtype = {article} } During the COVID-19 pandemic, some K-12 schools resumed in-person classes with varying degrees of mitigation plans in the fall 2020. Physical distancing and face coverings can minimize SARS-CoV-2 spread, the virus that causes COVID-19. However, no research has focused on adherence to mitigation strategies during school days. Thus, we sought to develop a systematic observation protocol to capture COVID-19 mitigation strategy adherence in school environments: The Systematic Observation of COVID-19 Mitigation (SOCOM). |
Black, Caroline Partner Emotional Support and Child Problem Behaviors: The Indirect Role of Harsh Parenting for Young Mothers and Their Children Journal Article Family Process, 2021. @article{Black2021, title = {Partner Emotional Support and Child Problem Behaviors: The Indirect Role of Harsh Parenting for Young Mothers and Their Children}, author = {Caroline Black}, url = {https://doi.org/10.1111/famp.12663}, doi = {10.1111/famp.12663}, year = {2021}, date = {2021-04-26}, journal = {Family Process}, abstract = {Emotionally supportive partners promote the well-being of teenage mothers and their children as they navigate sensitive developmental periods. Yet, having focused on young parents’ relationship dissolution, we know very little about benefits of partner supportiveness for the development of children’s psychological adjustment or processes that may explain this association. Using five waves of Fragile Families and Child Well-being Study data (N = 771) and parallel process latent growth curve modeling, this study tested whether trajectories of partner supportiveness (measured by maternal reports of fathers’ emotional support) directly mitigated trajectories of children’s externalizing and internalizing problem behaviors (measured by maternal reports of problem behaviors) and/or whether such effects were indirectly linked through lower levels of maternal harsh parenting (measured by observational ratings of mother-child interactions). Results suggest that higher levels of partner supportiveness at birth were associated with child externalizing and internalizing trajectories that started at lower levels and demonstrated slower improvements across time. Lower starting levels of maternal harsh parenting when children were three years old partially explained associations between partner supportiveness at birth and lower levels of child externalizing symptoms at age three. Lessons gleaned from this study are discussed in context of young families’ strengths and applied to practice-based settings.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Emotionally supportive partners promote the well-being of teenage mothers and their children as they navigate sensitive developmental periods. Yet, having focused on young parents’ relationship dissolution, we know very little about benefits of partner supportiveness for the development of children’s psychological adjustment or processes that may explain this association. Using five waves of Fragile Families and Child Well-being Study data (N = 771) and parallel process latent growth curve modeling, this study tested whether trajectories of partner supportiveness (measured by maternal reports of fathers’ emotional support) directly mitigated trajectories of children’s externalizing and internalizing problem behaviors (measured by maternal reports of problem behaviors) and/or whether such effects were indirectly linked through lower levels of maternal harsh parenting (measured by observational ratings of mother-child interactions). Results suggest that higher levels of partner supportiveness at birth were associated with child externalizing and internalizing trajectories that started at lower levels and demonstrated slower improvements across time. Lower starting levels of maternal harsh parenting when children were three years old partially explained associations between partner supportiveness at birth and lower levels of child externalizing symptoms at age three. Lessons gleaned from this study are discussed in context of young families’ strengths and applied to practice-based settings. |
Park, Daesik; Propper, Catherine R; Wang, Guangning; Salanga, Matthew C Ecotoxicology, 30 , pp. 711–718, 2021. @article{Park2021, title = {Synonymous single nucleotide polymorphism in arsenic (+3) methyltransferase of the Western mosquitofish (Gambusia affinis) and its gene expression among field populations}, author = {Daesik Park and Catherine R Propper and Guangning Wang and Matthew C Salanga }, url = {https://doi.org/10.1007/s10646-021-02376-8}, doi = {10.1007/s10646-021-02376-8}, year = {2021}, date = {2021-04-03}, journal = {Ecotoxicology}, volume = {30}, pages = {711–718}, abstract = {Naturally occurring arsenic is toxic at extremely low concentrations, yet some species persist even in high arsenic environments. We wanted to test if these species show evidence of evolution associated with arsenic exposure. To do this, we compared allelic variation across 872 coding nucleotides of arsenic (+3) methyltransferase (as3mt) and whole fish as3mt gene expression from three field populations of Gambusia affinis, from water sources containing low (1.9 ppb), medium-low (3.3 ppb), and high (15.7 ppb) levels of arsenic. The high arsenic site exceeds the US EPA's Maximum Contamination Level for drinking water. Medium-low and high populations exhibited homozygosity, and no sequence variation across all animals sampled. Eleven of 24 fish examined (45.8%) in the low arsenic population harbored synonymous single nucleotide polymorphisms (SNPs) in exons 4 and/or 10. SNP presence in the low arsenic population was not associated with differences in as3mt transcript levels compared to fish from the medium-low site, where SNPs were noted; however, as3mt expression in fish from the high arsenic concentration site was significantly lower than the other two sites. Low sequence variation in fish populations from sites with medium-low and high arsenic concentrations suggests greater selective pressure on this allele, while higher variation in the low population suggests a relaxed selection. Our results suggest gene regulation associated with arsenic detoxification may play a more crucial role in influencing responses to arsenic than polymorphic gene sequence. Understanding microevolutionary processes to various contaminants require the evaluation of multiple populations across a wide range of pollution exposures.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Naturally occurring arsenic is toxic at extremely low concentrations, yet some species persist even in high arsenic environments. We wanted to test if these species show evidence of evolution associated with arsenic exposure. To do this, we compared allelic variation across 872 coding nucleotides of arsenic (+3) methyltransferase (as3mt) and whole fish as3mt gene expression from three field populations of Gambusia affinis, from water sources containing low (1.9 ppb), medium-low (3.3 ppb), and high (15.7 ppb) levels of arsenic. The high arsenic site exceeds the US EPA's Maximum Contamination Level for drinking water. Medium-low and high populations exhibited homozygosity, and no sequence variation across all animals sampled. Eleven of 24 fish examined (45.8%) in the low arsenic population harbored synonymous single nucleotide polymorphisms (SNPs) in exons 4 and/or 10. SNP presence in the low arsenic population was not associated with differences in as3mt transcript levels compared to fish from the medium-low site, where SNPs were noted; however, as3mt expression in fish from the high arsenic concentration site was significantly lower than the other two sites. Low sequence variation in fish populations from sites with medium-low and high arsenic concentrations suggests greater selective pressure on this allele, while higher variation in the low population suggests a relaxed selection. Our results suggest gene regulation associated with arsenic detoxification may play a more crucial role in influencing responses to arsenic than polymorphic gene sequence. Understanding microevolutionary processes to various contaminants require the evaluation of multiple populations across a wide range of pollution exposures. |
Mousavi, Sajad; Afghah, Fatemeh; Khadem, Fatemeh; Acharya, Rajendra U ECG Language processing (ELP): A new technique to analyze ECG signals Journal Article Computer Methods and Programs in Biomedicine, 202 , 2021, ISBN: 105959. @article{Mousavi2021, title = {ECG Language processing (ELP): A new technique to analyze ECG signals}, author = {Sajad Mousavi and Fatemeh Afghah and Fatemeh Khadem and U. Rajendra Acharya}, url = {https://doi.org/10.1016/j.cmpb.2021.105959}, doi = {10.1016/j.cmpb.2021.105959}, isbn = {105959}, year = {2021}, date = {2021-04-01}, journal = {Computer Methods and Programs in Biomedicine}, volume = {202}, abstract = {A language is constructed of a finite/infinite set of sentences composing of words. Similar to natural languages, the Electrocardiogram (ECG) signal, the most common noninvasive tool to study the functionality of the heart and diagnose several abnormal arrhythmias, is made up of sequences of three or four distinct waves, including the P-wave, QRS complex, T-wave, and U-wave. An ECG signal may contain several different varieties of each wave (e.g., the QRS complex can have various appearances). For this reason, the ECG signal is a sequence of heartbeats similar to sentences in natural languages) and each heartbeat is composed of a set of waves (similar to words in a sentence) of different morphologies. Experimental results on three databases (i.e., PhysioNet’s MIT-BIH, MIT-BIH AFIB, and PhysioNet Challenge 2017 AFIB Dataset databases) reveal that the proposed approach as a general idea can be applied to a variety of biomedical applications and can achieve remarkable performance.}, keywords = {}, pubstate = {published}, tppubtype = {article} } A language is constructed of a finite/infinite set of sentences composing of words. Similar to natural languages, the Electrocardiogram (ECG) signal, the most common noninvasive tool to study the functionality of the heart and diagnose several abnormal arrhythmias, is made up of sequences of three or four distinct waves, including the P-wave, QRS complex, T-wave, and U-wave. An ECG signal may contain several different varieties of each wave (e.g., the QRS complex can have various appearances). For this reason, the ECG signal is a sequence of heartbeats similar to sentences in natural languages) and each heartbeat is composed of a set of waves (similar to words in a sentence) of different morphologies. Experimental results on three databases (i.e., PhysioNet’s MIT-BIH, MIT-BIH AFIB, and PhysioNet Challenge 2017 AFIB Dataset databases) reveal that the proposed approach as a general idea can be applied to a variety of biomedical applications and can achieve remarkable performance. |
Evans, Linnea; Engelman, Michal; Mikulas, Alex; Malecki, Kristen How are social determinants of health integrated into epigenetic research? A systematic review Journal Article Social Science & Medicine, 273 , 2021, ISBN: 113738. @article{Evans2021, title = {How are social determinants of health integrated into epigenetic research? A systematic review}, author = {Linnea Evans and Michal Engelman and Alex Mikulas and Kristen Malecki}, url = {https://doi.org/10.1016/j.socscimed.2021.113738}, doi = {10.1016/j.socscimed.2021.113738}, isbn = {113738}, year = {2021}, date = {2021-03-01}, journal = {Social Science & Medicine}, volume = {273}, abstract = {Future social epigenetics research should prioritize larger, more diverse and representative population-based samples and employ the SDOH framework to better inform the conceptualization of research questions and interpretation of findings. In particular, the simplified depiction of race/ethnicity, gender, and socioeconomic status as individual-level characteristics should be updated with an explicit acknowledgement that these characteristics are more accurately interpreted as cues used by society to differentiate subpopulations. Social epigenetics research can then more clearly elucidate the biological consequences of these social exposures for patterns of gene expression, subsequent disease etiology, and health inequities.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Future social epigenetics research should prioritize larger, more diverse and representative population-based samples and employ the SDOH framework to better inform the conceptualization of research questions and interpretation of findings. In particular, the simplified depiction of race/ethnicity, gender, and socioeconomic status as individual-level characteristics should be updated with an explicit acknowledgement that these characteristics are more accurately interpreted as cues used by society to differentiate subpopulations. Social epigenetics research can then more clearly elucidate the biological consequences of these social exposures for patterns of gene expression, subsequent disease etiology, and health inequities. |
Fotoohinasab, Atiyeh; Hocking, Toby; Afghah, Fatemeh A greedy graph search algorithm based on changepoint analysis for automatic QRS complex detection Journal Article Computers in Biology and Medicine, 130 , 2021, ISBN: 104208. @article{Fotoohinasab2021, title = {A greedy graph search algorithm based on changepoint analysis for automatic QRS complex detection}, author = {Atiyeh Fotoohinasab and Toby Hocking and Fatemeh Afghah}, url = {https://doi.org/10.1016/j.compbiomed.2021.104208}, doi = {10.1016/j.compbiomed.2021.104208}, isbn = {104208}, year = {2021}, date = {2021-03-01}, journal = {Computers in Biology and Medicine}, volume = {130}, abstract = {The electrocardiogram (ECG) signal is the most widely used non-invasive tool for the investigation of cardiovascular diseases. Automatic delineation of ECG fiducial points, in particular the R-peak, serves as the basis for ECG processing and analysis. This study proposes a new method of ECG signal analysis by introducing a new class of graphical models based on optimal changepoint detection models, named the graph-constrained changepoint detection (GCCD) model. The GCCD model treats fiducial points delineation in the non-stationary ECG signal as a changepoint detection problem. The proposed model exploits the sparsity of changepoints to detect abrupt changes within the ECG signal; thereby, the R-peak detection task can be relaxed from any preprocessing step. In this novel approach, prior biological knowledge about the expected sequence of changes is incorporated into the model using the constraint graph, which can be defined manually or automatically. First, we define the constraint graph manually; then, we present a graph learning algorithm that can search for an optimal graph in a greedy scheme. Finally, we compare the manually defined graphs and learned graphs in terms of graph structure and detection accuracy. We evaluate the performance of the algorithm using the MIT-BIH Arrhythmia Database. The proposed model achieves an overall sensitivity of 99.64%, positive predictivity of 99.71%, and detection error rate of 0.19 for the manually defined constraint graph and overall sensitivity of 99.76%, positive predictivity of 99.68%, and detection error rate of 0.55 for the automatic learning constraint graph.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The electrocardiogram (ECG) signal is the most widely used non-invasive tool for the investigation of cardiovascular diseases. Automatic delineation of ECG fiducial points, in particular the R-peak, serves as the basis for ECG processing and analysis. This study proposes a new method of ECG signal analysis by introducing a new class of graphical models based on optimal changepoint detection models, named the graph-constrained changepoint detection (GCCD) model. The GCCD model treats fiducial points delineation in the non-stationary ECG signal as a changepoint detection problem. The proposed model exploits the sparsity of changepoints to detect abrupt changes within the ECG signal; thereby, the R-peak detection task can be relaxed from any preprocessing step. In this novel approach, prior biological knowledge about the expected sequence of changes is incorporated into the model using the constraint graph, which can be defined manually or automatically. First, we define the constraint graph manually; then, we present a graph learning algorithm that can search for an optimal graph in a greedy scheme. Finally, we compare the manually defined graphs and learned graphs in terms of graph structure and detection accuracy. We evaluate the performance of the algorithm using the MIT-BIH Arrhythmia Database. The proposed model achieves an overall sensitivity of 99.64%, positive predictivity of 99.71%, and detection error rate of 0.19 for the manually defined constraint graph and overall sensitivity of 99.76%, positive predictivity of 99.68%, and detection error rate of 0.55 for the automatic learning constraint graph. |
Kahn, Carmella B; Dreifuss, Heather; Teufel-Shone, Nicolette I; Tutt, Marissa; McCue, Kelly; Wilson, Jamie; Waters, Amber-Rose; Belin, Kalvina L; Bauer, Mark C Adapting Summer Education Programs for Navajo Students: Resilient Teamwork Journal Article Frontiers in Sociology, 2021. @article{Kahn2021, title = {Adapting Summer Education Programs for Navajo Students: Resilient Teamwork}, author = {Carmella B. Kahn and Heather Dreifuss and Nicolette I. Teufel-Shone and Marissa Tutt and Kelly McCue and Jamie Wilson and Amber-Rose Waters and Kalvina L. Belin and Mark C. Bauer}, url = {https://doi.org/10.3389/fsoc.2021.617994}, doi = {10.3389/fsoc.2021.617994}, year = {2021}, date = {2021-02-08}, journal = {Frontiers in Sociology}, abstract = {In May 2020, the Navajo Native American Research Center for Health Partnership (Navajo NARCH) was scheduled to launch two summer programs: a 10 weeks-long Summer Research Enhancement Program (SREP) for undergraduate students to learn and practice health research methods and participate in a practicum experience, and a week-long Indigenous Summer Enhancement Program (ISEP) for high school students that introduces a range of health professions and develops leadership qualities. Students accepted into the programs are predominantly Navajo and live within Navajo Nation (NN) during the summer. Due to NN restrictions and CDC guidelines for physically distancing in response to the coronavirus (COVID-19) pandemic, the Navajo NARCH team organized to offer both programs entirely online via Zoom™. This paper explores the instructional teams’ adaptation process to maintain a commitment to preserve the programs’ supportive environment for exploring and developing strong multicultural approaches in public health and health research. In preparation for online instruction, the team developed and offered workshops for staff and instructors to address anticipated challenges. The team identified the following challenges: technological difficulties, social disconnectedness, consistent student engagement, and facilitation of a practicum research experience. Results showed that program adaptations were successful as the team applied collaborative and holistic approaches, and established social connections remotely with students to offer meaningful research and practicum experiences.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In May 2020, the Navajo Native American Research Center for Health Partnership (Navajo NARCH) was scheduled to launch two summer programs: a 10 weeks-long Summer Research Enhancement Program (SREP) for undergraduate students to learn and practice health research methods and participate in a practicum experience, and a week-long Indigenous Summer Enhancement Program (ISEP) for high school students that introduces a range of health professions and develops leadership qualities. Students accepted into the programs are predominantly Navajo and live within Navajo Nation (NN) during the summer. Due to NN restrictions and CDC guidelines for physically distancing in response to the coronavirus (COVID-19) pandemic, the Navajo NARCH team organized to offer both programs entirely online via Zoom™. This paper explores the instructional teams’ adaptation process to maintain a commitment to preserve the programs’ supportive environment for exploring and developing strong multicultural approaches in public health and health research. In preparation for online instruction, the team developed and offered workshops for staff and instructors to address anticipated challenges. The team identified the following challenges: technological difficulties, social disconnectedness, consistent student engagement, and facilitation of a practicum research experience. Results showed that program adaptations were successful as the team applied collaborative and holistic approaches, and established social connections remotely with students to offer meaningful research and practicum experiences. |
Yagüe, David Panisello; Mihaljevic, Joseph; Mbegbu, M; Wood, C V; Hepp, Crystal; Kyman, S; Hornstra, H; Trotter, Robert; Cope, Emily; Pearson, Talima Survival of Staphylococcus aureus on sampling swabs stored at different temperatures Journal Article Journal of Applied Microbiology, 2021. @article{Yagüe2021, title = {Survival of Staphylococcus aureus on sampling swabs stored at different temperatures}, author = {David Panisello Yagüe and Joseph Mihaljevic and M. Mbegbu and C.V. Wood and Crystal Hepp and S. Kyman and H. Hornstra and Robert Trotter and Emily Cope and Talima Pearson}, url = {https://doi.org/10.1111/jam.15023}, doi = {10.1111/jam.15023}, year = {2021}, date = {2021-02-05}, journal = {Journal of Applied Microbiology}, abstract = {Epidemiological studies of bacterial diseases are typically limited to determination of pathogen presence/absence, yet quantitative assessments of pathogen load and genetic diversity can provide insights into disease progression and severity, likelihood of transmission and adaptive evolutionary potential. For studies of S. aureus where time or access to a microbiology laboratory may delay culturing, deep freezing or timely culturing will maximize the degree to which sampling results reflect source status.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Epidemiological studies of bacterial diseases are typically limited to determination of pathogen presence/absence, yet quantitative assessments of pathogen load and genetic diversity can provide insights into disease progression and severity, likelihood of transmission and adaptive evolutionary potential. For studies of S. aureus where time or access to a microbiology laboratory may delay culturing, deep freezing or timely culturing will maximize the degree to which sampling results reflect source status. |
Schmitz, Kathryn H; Stout, Nicole L; Maitin-Shepard, Melissa; Campbell, Anna; Schwartz, Anna L; Grimmett, Chloe; Meyerhardt, Jeffrey A; Sokolof, Jonas M Moving through cancer: Setting the agenda to make exercise standard in oncology practice Journal Article Cancer, 127 (3), pp. 476-484, 2021, ISBN: 10.1002/cncr.33245. @article{Schmitz2021, title = {Moving through cancer: Setting the agenda to make exercise standard in oncology practice}, author = {Kathryn H Schmitz and Nicole L Stout and Melissa Maitin-Shepard and Anna Campbell and Anna L Schwartz and Chloe Grimmett and Jeffrey A Meyerhardt and Jonas M Sokolof}, url = {https://doi.org/10.1002/cncr.33245}, isbn = {10.1002/cncr.33245}, year = {2021}, date = {2021-02-01}, journal = {Cancer}, volume = {127}, number = {3}, pages = {476-484}, abstract = {International evidence-based guidelines support the prescription of exercise for all individuals living with and beyond cancer. This article describes the agenda of the newly formed Moving Through Cancer initiative, which has a primary objective of making exercise standard practice in oncology by 2029.}, keywords = {}, pubstate = {published}, tppubtype = {article} } International evidence-based guidelines support the prescription of exercise for all individuals living with and beyond cancer. This article describes the agenda of the newly formed Moving Through Cancer initiative, which has a primary objective of making exercise standard practice in oncology by 2029. |
Giano, Zachary; Camplain, Ricky L; Camplain, Carolyn; Pro, George; Haberstroh, Shane; Baldwin, Julie A; Wheeler, Denna L; Hubach, Randolph D Adverse Childhood Events in American Indian/Alaska Native Populations Journal Article American Journal of Preventive Medicine, 60 (2), pp. 213-221, 2021. @article{Giano2021, title = {Adverse Childhood Events in American Indian/Alaska Native Populations}, author = {Zachary Giano and Ricky L Camplain and Carolyn Camplain and George Pro and Shane Haberstroh and Julie A Baldwin and Denna L Wheeler and Randolph D Hubach}, url = {https://doi.org/10.1016/j.amepre.2020.08.020}, doi = {10.1016/j.amepre.2020.08.020}, year = {2021}, date = {2021-02-01}, journal = {American Journal of Preventive Medicine}, volume = {60}, number = {2}, pages = {213-221}, abstract = {Adverse childhood experiences are linked to deleterious outcomes in adulthood. Certain populations have been shown to be more vulnerable to adversity in childhood than others. Despite these findings, research in this area lacks an empirical investigation that examines adverse childhood experiences among American Indian and Alaska Native populations using large, nationally representative data. As such, the authors have compiled what they believe is the largest empirical investigation of adverse childhood experiences among American Indian and Alaska Native individuals to date.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Adverse childhood experiences are linked to deleterious outcomes in adulthood. Certain populations have been shown to be more vulnerable to adversity in childhood than others. Despite these findings, research in this area lacks an empirical investigation that examines adverse childhood experiences among American Indian and Alaska Native populations using large, nationally representative data. As such, the authors have compiled what they believe is the largest empirical investigation of adverse childhood experiences among American Indian and Alaska Native individuals to date. |
Ladner, Jason T; Henson, Sierra N; Boyle, Annalee S; Engelbrektson, Anna L; Fink, Zane W; Rahee, Fatima; D'ambrozio, Jonathan; Schaecher, Kurt E; Stone, Mars; Dong, Wenjuan; Dadwal, Sanjeet; Yu, Jianhua; Caligiuri, Michael A; Cieplak, Piotr; Bjørås, Magnar; Fenstad, Mona H; Nordbø, Svein A; Kainov, Denis E; Muranaka, Norihito; Chee, Mark S; Shiryaev, Sergey A; Altin, John A Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses Journal Article Cell Reports Medicine, 2 ( 1), 2021. @article{Ladner2021, title = {Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses}, author = {Jason T Ladner and Sierra N Henson and Annalee S Boyle and Anna L Engelbrektson and Zane W Fink and Fatima Rahee and Jonathan D'ambrozio and Kurt E Schaecher and Mars Stone and Wenjuan Dong and Sanjeet Dadwal and Jianhua Yu and Michael A Caligiuri and Piotr Cieplak and Magnar Bjørås and Mona H Fenstad and Svein A Nordbø and Denis E Kainov and Norihito Muranaka and Mark S Chee and Sergey A Shiryaev and John A Altin}, url = {https://doi.org/10.1016/j.xcrm.2020.100189}, doi = {10.1016/j.xcrm.2020.100189}, year = {2021}, date = {2021-01-19}, journal = {Cell Reports Medicine}, volume = {2}, number = { 1}, abstract = {The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity using a highly multiplexed peptide assay (PepSeq) to generate an epitope-resolved view of IgG reactivity across all human CoVs in both COVID-19 convalescent and negative donors. PepSeq resolves epitopes across the SARS-CoV-2 Spike and Nucleocapsid proteins that are commonly targeted in convalescent donors, including several sites also recognized in some uninfected controls. By comparing patterns of homologous reactivity between CoVs and using targeted antibody-depletion experiments, we demonstrate that SARS-CoV-2 elicits antibodies that cross-recognize pandemic and endemic CoV antigens at two Spike S2 subunit epitopes. We further show that these cross-reactive antibodies preferentially bind endemic homologs. Our findings highlight sites at which the SARS-CoV-2 response appears to be shaped by previous CoV exposures and which have the potential to raise broadly neutralizing responses.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity using a highly multiplexed peptide assay (PepSeq) to generate an epitope-resolved view of IgG reactivity across all human CoVs in both COVID-19 convalescent and negative donors. PepSeq resolves epitopes across the SARS-CoV-2 Spike and Nucleocapsid proteins that are commonly targeted in convalescent donors, including several sites also recognized in some uninfected controls. By comparing patterns of homologous reactivity between CoVs and using targeted antibody-depletion experiments, we demonstrate that SARS-CoV-2 elicits antibodies that cross-recognize pandemic and endemic CoV antigens at two Spike S2 subunit epitopes. We further show that these cross-reactive antibodies preferentially bind endemic homologs. Our findings highlight sites at which the SARS-CoV-2 response appears to be shaped by previous CoV exposures and which have the potential to raise broadly neutralizing responses. |
Magdaleno, Carina; House, Trenton; Pawar, Jogendra S; Carvalho, Sophia; Rajasekaran, Narendiran; Varadaraj, Archana Fibronectin assembly regulates lumen formation in breast acini Journal Article Journal of Cellular Biochemistry, 2021. @article{Magdaleno2021, title = {Fibronectin assembly regulates lumen formation in breast acini}, author = {Carina Magdaleno and Trenton House and Jogendra S. Pawar and Sophia Carvalho and Narendiran Rajasekaran and Archana Varadaraj}, url = {https://doi.org/10.1002/jcb.29885}, doi = {10.1002/jcb.29885}, year = {2021}, date = {2021-01-13}, journal = {Journal of Cellular Biochemistry}, abstract = {Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self‐assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial‐to‐mesenchymal transition. The role of the FN matrix of epithelial cells in driving such processes remains less well understood and is the focus of this study. Hypoxia, defined by low oxygen tension (<5%) is one of the hallmarks of tumor microenvironments impacting fibril reorganization in stromal and epithelial cells. Here, using the MCF10 breast epithelial progression series of cell lines encompassing normal, preinvasive, and invasive states, we show that FN fibril formation decreases during hypoxia, coinciding with a decrease in migratory potential of these cells. Conversely, we find that FN fibril disruption during three‐dimensional acinar growth of normal breast cells resulted in acinar luminal filling. Our data also demonstrates that the luminal filling upon fibril disruption in untransformed MCF10A cells results in a loss of apicobasal polarity, characteristic of pre‐invasive and invasive breast cell lines MCF10AT and MCF10 DCIS.com. Overall this is the first study that relates fibril‐mediated changes in epithelial cells as critical players in lumen clearing of breast acini and maintenance of the untransformed growth characteristic. |
Miller, Erin; Barragan, Veronica; Chiriboga, Jorge; Weddell, Chad; Luna, Ligia; Jiménez, Dulce J; Aleman, John; Mihaljevic, Joseph R; Olivas, Sonora; Marks, Jane; Izurieta, Ricardo; Nieto, Nathan; Keim, Paul; Trueba, Gabriel; Caporaso, Gregory J; Pearson, Talima Leptospira in river and soil in a highly endemic area of Ecuador Journal Article BMC Microbiology, 21 (1), 2021. @article{Miller2021, title = {Leptospira in river and soil in a highly endemic area of Ecuador}, author = {Erin Miller and Veronica Barragan and Jorge Chiriboga and Chad Weddell and Ligia Luna and Dulce J Jiménez and John Aleman and Joseph R Mihaljevic and Sonora Olivas and Jane Marks and Ricardo Izurieta and Nathan Nieto and Paul Keim and Gabriel Trueba and J Gregory Caporaso and Talima Pearson}, url = {https://doi.org/10.1186/s12866-020-02069-y}, doi = {10.1186/s12866-020-02069-y}, year = {2021}, date = {2021-01-07}, journal = {BMC Microbiology}, volume = {21}, number = {1}, abstract = {Leptospira are shed into the environment via urine of infected animals. Rivers are thought to be an important risk factor for transmission to humans, though much is unknown about the types of environment or characteristics that favor survival. To address this, we screened for Leptospira DNA in two rivers in rural Ecuador where Leptospirosis is endemic.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Leptospira are shed into the environment via urine of infected animals. Rivers are thought to be an important risk factor for transmission to humans, though much is unknown about the types of environment or characteristics that favor survival. To address this, we screened for Leptospira DNA in two rivers in rural Ecuador where Leptospirosis is endemic. |
Ransdell, Lynda B; Lane, Taylor S; Schwartz, Anna L; Wayment, Heidi A; Baldwin, Julie A International Journal of Environmental Research and Public Health, 18 (2), pp. 1-35, 2021. @article{Ransdell2021, title = {Mentoring new and early-stage investigators and underrepresented minority faculty for research success in health-related fields: An integrative literature review (2010-2020)}, author = {Lynda B. Ransdell and Taylor S. Lane and Anna L. Schwartz and Heidi A. Wayment and Julie A. Baldwin}, url = {https://doi.org/10.3390/ijerph18020432}, doi = {10.3390/ijerph18020432}, year = {2021}, date = {2021-01-07}, journal = {International Journal of Environmental Research and Public Health}, volume = {18}, number = {2}, pages = {1-35}, abstract = {Mentoring to develop research skills is an important strategy for facilitating faculty success. The purpose of this study was to conduct an integrative literature review to examine the barriers and facilitators to mentoring in health-related research, particularly for three categories: New investigators (NI), early-stage investigators (ESI) and underrepresented minority faculty (UMF). PsychINFO, CINAHL and PubMed were searched for papers published in English from 2010 to 2020, and 46 papers were reviewed. Most papers recommended having multiple mentors and many recommended assessing baseline research skills. Barriers and facilitators were both individual and institutional. Individual barriers mentioned most frequently were a lack of time and finding work-life balance. UMF mentioned barriers related to bias, discrimination and isolation. Institutional barriers included lack of mentors, lack of access to resources, and heavy teaching and service loads. UMF experienced institutional barriers such as devaluation of experience or expertise. Individual facilitators were subdivided and included writing and synthesis as technical skills, networking and collaborating as interpersonal skills, and accountability, leadership, time management, and resilience/grit as personal skills. Institutional facilitators included access to mentoring, professional development opportunities, and workload assigned to research. Advocacy for diversity and cultural humility were included as unique interpersonal and institutional facilitators for UMF. Several overlapping and unique barriers and facilitators to mentoring for research success for NI, ESI and UMF in the health-related disciplines are presented.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Mentoring to develop research skills is an important strategy for facilitating faculty success. The purpose of this study was to conduct an integrative literature review to examine the barriers and facilitators to mentoring in health-related research, particularly for three categories: New investigators (NI), early-stage investigators (ESI) and underrepresented minority faculty (UMF). PsychINFO, CINAHL and PubMed were searched for papers published in English from 2010 to 2020, and 46 papers were reviewed. Most papers recommended having multiple mentors and many recommended assessing baseline research skills. Barriers and facilitators were both individual and institutional. Individual barriers mentioned most frequently were a lack of time and finding work-life balance. UMF mentioned barriers related to bias, discrimination and isolation. Institutional barriers included lack of mentors, lack of access to resources, and heavy teaching and service loads. UMF experienced institutional barriers such as devaluation of experience or expertise. Individual facilitators were subdivided and included writing and synthesis as technical skills, networking and collaborating as interpersonal skills, and accountability, leadership, time management, and resilience/grit as personal skills. Institutional facilitators included access to mentoring, professional development opportunities, and workload assigned to research. Advocacy for diversity and cultural humility were included as unique interpersonal and institutional facilitators for UMF. Several overlapping and unique barriers and facilitators to mentoring for research success for NI, ESI and UMF in the health-related disciplines are presented. |
2020 |
Roy, Indrakshi; Karmarkar, Amol; Kumar, Amit; Warren, Meghan; Pohl, Patricia; Shaibi, Stefany; Rivera-Hernandez, Maricruz; Rudolph, James Racial Differences in Post-Acute Transition After Hip Fracture in Medicare Patients With ADRD Journal Article Innovation in Aging, 4 (1), pp. 666–667, 2020. @article{Roy2020, title = {Racial Differences in Post-Acute Transition After Hip Fracture in Medicare Patients With ADRD }, author = {Indrakshi Roy and Amol Karmarkar and Amit Kumar and Meghan Warren and Patricia Pohl and Stefany Shaibi and Maricruz Rivera-Hernandez and James Rudolph}, url = {https://doi.org/10.1093/geroni/igaa057.2307}, doi = {10.1093/geroni/igaa057.2307}, year = {2020}, date = {2020-12-16}, journal = {Innovation in Aging}, volume = {4}, number = {1}, pages = {666–667}, abstract = {The incidence of hip fractures in patients with Alzheimer’s disease and related dementias (ADRD) is 2.7 times higher than it is in those without ADRD. However, there are no standardized post-acute transition models for patients with ADRD after hip fracture. Additionally, there is a lack of knowledge on how post-acute transitions vary by race/ethnicity. Using 100% Medicare data (2016-2017) for 120,179 older adults with ADRD, we conduct multinomial logistic regression, to examine the association between race and post-acute discharge locations (proportion discharged to skilled nursing facility [SNF], inpatient rehabilitation facility [IRF], and Home with Home Health Care [HHC]), after accounting for patient characteristics. Compared to non-Hispanic Whites, Hispanics have a significantly lower odds ratio for discharge to HHC 0.62 (95%CI=0.53-0.73), IRF 0.44 (CI=0.39-0.51), and SNF 0.26 (CI=0.23-0.30). Improving care in patients with ADRD and reducing racial and ethnic disparities in quality of care and health outcomes will be discussed. }, keywords = {}, pubstate = {published}, tppubtype = {article} } The incidence of hip fractures in patients with Alzheimer’s disease and related dementias (ADRD) is 2.7 times higher than it is in those without ADRD. However, there are no standardized post-acute transition models for patients with ADRD after hip fracture. Additionally, there is a lack of knowledge on how post-acute transitions vary by race/ethnicity. Using 100% Medicare data (2016-2017) for 120,179 older adults with ADRD, we conduct multinomial logistic regression, to examine the association between race and post-acute discharge locations (proportion discharged to skilled nursing facility [SNF], inpatient rehabilitation facility [IRF], and Home with Home Health Care [HHC]), after accounting for patient characteristics. Compared to non-Hispanic Whites, Hispanics have a significantly lower odds ratio for discharge to HHC 0.62 (95%CI=0.53-0.73), IRF 0.44 (CI=0.39-0.51), and SNF 0.26 (CI=0.23-0.30). Improving care in patients with ADRD and reducing racial and ethnic disparities in quality of care and health outcomes will be discussed. |
Wagner, Eric F; Baldwin, Julie A Recovery in Special Emphasis Populations Journal Article Alcohol Research Current Reviews, 40 (3), 2020. @article{Wagner2020, title = {Recovery in Special Emphasis Populations}, author = {Eric F. Wagner and Julie A. Baldwin}, url = {https://arcr.niaaa.nih.gov/recovery-aud/recovery-special-emphasis-populations}, doi = {10.35946/arcr.v40.3.05}, year = {2020}, date = {2020-12-10}, journal = {Alcohol Research Current Reviews}, volume = {40}, number = {3}, abstract = {Special emphasis populations in the current context can be defined as groups experiencing health disparities resulting in elevated risk to health, safety, and well-being from drinking alcohol. Individuals from marginalized minority populations often encounter barriers to accessing and receiving effective alcohol treatment due to social inequities and disadvantaged life contexts, which also may adversely affect recovery from alcohol use disorder (AUD). Recovery from AUD often involves the adoption of a stable non-drinking lifestyle (sobriety), increased health and well-being, and increased social connection. Although there has been considerable work on AUD epidemiology among special emphasis populations, little research exists directly examining recovery among racial/ethnic minority populations and/or sexual and gender minority populations. The current narrative review hopes to spark scholarly interest in this critically neglected area. This article opens with a review of special emphasis populations and their alcohol-related risks. Next, definitions of recovery, Alcoholics Anonymous, and culturally adapted recovery models for racial/ethnic minority populations are explored. This is followed by a discussion of factors that may particularly influence recovery among marginalized minority populations. This narrative review concludes with a discussion of research priorities for promoting health equity through studies focused on understanding and supporting recovery from AUD among marginalized minority populations}, keywords = {}, pubstate = {published}, tppubtype = {article} } Special emphasis populations in the current context can be defined as groups experiencing health disparities resulting in elevated risk to health, safety, and well-being from drinking alcohol. Individuals from marginalized minority populations often encounter barriers to accessing and receiving effective alcohol treatment due to social inequities and disadvantaged life contexts, which also may adversely affect recovery from alcohol use disorder (AUD). Recovery from AUD often involves the adoption of a stable non-drinking lifestyle (sobriety), increased health and well-being, and increased social connection. Although there has been considerable work on AUD epidemiology among special emphasis populations, little research exists directly examining recovery among racial/ethnic minority populations and/or sexual and gender minority populations. The current narrative review hopes to spark scholarly interest in this critically neglected area. This article opens with a review of special emphasis populations and their alcohol-related risks. Next, definitions of recovery, Alcoholics Anonymous, and culturally adapted recovery models for racial/ethnic minority populations are explored. This is followed by a discussion of factors that may particularly influence recovery among marginalized minority populations. This narrative review concludes with a discussion of research priorities for promoting health equity through studies focused on understanding and supporting recovery from AUD among marginalized minority populations |
Eaves, Emery; II, Robert Trotter T; Baldwin, Julie A Human Organization, 79 (4), pp. 292-303, 2020. @article{Eaves2020b, title = {Another silver lining?: Anthropological perspectives on the promise and practice of relaxed restrictions for telemedicine and medication-assisted treatment in the context of COVID-19}, author = {Emery Eaves and Robert T. Trotter II and Julie A. Baldwin}, url = {https://meridian.allenpress.com/human-organization/article-abstract/79/4/292/449044/Another-Silver-Lining-Anthropological-Perspectives?redirectedFrom=fulltext}, doi = {10.17730/1938-3525-79.4.292}, year = {2020}, date = {2020-12-02}, journal = {Human Organization}, volume = {79}, number = {4}, pages = {292-303}, abstract = {As a response to the COVID-19 pandemic, the United States Drug Enforcement Administration (DEA) has temporarily relaxed restrictions to serve people who are opioid dependent during social distancing mandates. Changes include allowing patients to take home more doses of methadone and buprenorphine rather than coming to the clinic every day (for methadone) or weekly (for buprenorphine) and relaxed restrictions on telehealth delivery. Telemedicine Program representatives have described the relaxing of federal regulations as a "silver lining" to the COVID-19 pandemic. Drawing from medical anthropology approaches to epidemic surveillance and understandings of risk, we critically evaluate media representations of recent changes to telemedicine, prescribing, and opioid treatment delivery. Ethnographic research with providers and stakeholders in Arizona from 2017 to the present add insight to our analysis of media reports on these topics. Our findings demonstrate that media portrayal of access to medication-assisted treatment (MAT) as the key to preventing both COVID-19 and overdose among people who are opioid dependent misses important risks and potential inequities. Applied social science questions raised by the new guidelines include: who receives take-home doses of methadone and buprenorphine and why; and how media representations of risk and benefit rationales shape real-world policy and practice.}, keywords = {}, pubstate = {published}, tppubtype = {article} } As a response to the COVID-19 pandemic, the United States Drug Enforcement Administration (DEA) has temporarily relaxed restrictions to serve people who are opioid dependent during social distancing mandates. Changes include allowing patients to take home more doses of methadone and buprenorphine rather than coming to the clinic every day (for methadone) or weekly (for buprenorphine) and relaxed restrictions on telehealth delivery. Telemedicine Program representatives have described the relaxing of federal regulations as a "silver lining" to the COVID-19 pandemic. Drawing from medical anthropology approaches to epidemic surveillance and understandings of risk, we critically evaluate media representations of recent changes to telemedicine, prescribing, and opioid treatment delivery. Ethnographic research with providers and stakeholders in Arizona from 2017 to the present add insight to our analysis of media reports on these topics. Our findings demonstrate that media portrayal of access to medication-assisted treatment (MAT) as the key to preventing both COVID-19 and overdose among people who are opioid dependent misses important risks and potential inequities. Applied social science questions raised by the new guidelines include: who receives take-home doses of methadone and buprenorphine and why; and how media representations of risk and benefit rationales shape real-world policy and practice. |
Mousavi, Sajad; Afghah, Fatemeh; Acharya, Rajendra U HAN-ECG: An interpretable atrial fibrillation detection model using hierarchical attention networks Journal Article Computers in Biology and Medicine, 127 , 2020. @article{Mousavi2020b, title = {HAN-ECG: An interpretable atrial fibrillation detection model using hierarchical attention networks}, author = {Sajad Mousavi and Fatemeh Afghah and U Rajendra Acharya}, url = {https://www.sciencedirect.com/science/article/pii/S0010482520303887?via%3Dihub}, doi = {10.1016/j.compbiomed.2020.104057}, year = {2020}, date = {2020-12-01}, journal = {Computers in Biology and Medicine}, volume = {127}, abstract = {Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias that affects the lives of many people around the world and is associated with a five-fold increased risk of stroke and mortality. Like other problems in the healthcare domain, artificial intelligence (AI)-based models have been used to detect AF from patients' ECG signals. The cardiologist level performance in detecting this arrhythmia is often achieved by deep learning-based methods, however, they suffer from the lack of interpretability. In other words, these approaches are unable to explain the reasons behind their decisions. The lack of interpretability is a common challenge toward a wide application of machine learning (ML)-based approaches in the healthcare which limits the trust of clinicians in such methods. To address this challenge, we propose HAN-ECG, an interpretable bidirectional-recurrent-neural-network-based approach for the AF detection task. The HAN-ECG employs three attention mechanism levels to provide a multi-resolution analysis of the patterns in ECG leading to AF. The detected patterns by this hierarchical attention model facilitate the interpretation of the neural network decision process in identifying the patterns in the signal which contributed the most to the final detection. Experimental results on two AF databases demonstrate that our proposed model performs better than the existing algorithms. Visualization of these attention layers illustrates that our proposed model decides upon the important waves and heartbeats which are clinically meaningful in the detection task (e.g., absence of P-waves, and irregular R-R intervals for the AF detection task).}, keywords = {}, pubstate = {published}, tppubtype = {article} } Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias that affects the lives of many people around the world and is associated with a five-fold increased risk of stroke and mortality. Like other problems in the healthcare domain, artificial intelligence (AI)-based models have been used to detect AF from patients' ECG signals. The cardiologist level performance in detecting this arrhythmia is often achieved by deep learning-based methods, however, they suffer from the lack of interpretability. In other words, these approaches are unable to explain the reasons behind their decisions. The lack of interpretability is a common challenge toward a wide application of machine learning (ML)-based approaches in the healthcare which limits the trust of clinicians in such methods. To address this challenge, we propose HAN-ECG, an interpretable bidirectional-recurrent-neural-network-based approach for the AF detection task. The HAN-ECG employs three attention mechanism levels to provide a multi-resolution analysis of the patterns in ECG leading to AF. The detected patterns by this hierarchical attention model facilitate the interpretation of the neural network decision process in identifying the patterns in the signal which contributed the most to the final detection. Experimental results on two AF databases demonstrate that our proposed model performs better than the existing algorithms. Visualization of these attention layers illustrates that our proposed model decides upon the important waves and heartbeats which are clinically meaningful in the detection task (e.g., absence of P-waves, and irregular R-R intervals for the AF detection task). |
Roy, Indrakshi; Karmarkar, Amol; Kumar, Amit; Warren, Meghan; Pohl, Patricia; Rivera-Hernandez, Maricruz Utilization After Hip Fracture in Medicare Beneficiaries With ADRD Journal Article Innovation in Aging, 4 (1), pp. 59, 2020. @article{Roy2020b, title = {Utilization After Hip Fracture in Medicare Beneficiaries With ADRD}, author = {Indrakshi Roy and Amol Karmarkar and Amit Kumar and Meghan Warren and Patricia Pohl and Maricruz Rivera-Hernandez}, url = {https://doi.org/10.1093/geroni/igaa057.192}, doi = {10.1093/geroni/igaa057.192}, year = {2020}, date = {2020-12-01}, journal = {Innovation in Aging}, volume = {4}, number = {1}, pages = {59}, abstract = {The incidence of hip fracture in patients with Alzheimer’s disease and related dementias (ADRD) is 2.7 times higher than it is in those without ADRD. Care complexity, including extensive post-acute rehabilitation, increases substantially in patients with ADRD after hip fracture. However, there are no standardized post-acute care utilization models for patients with ADRD after hip fracture. Additionally, there is a lack of knowledge on how post-acute utilization varies by race/ethnicity, in this population. To investigate racial differences in post-acute care utilization following hip fracture related hospitalization in patients with ADRD. A secondary analysis was conducted on 120,179 older adults with ADRD with incident hip fracture, using 100% Medicare data (2016-2017). The primary outcome was post-acute discharge dispositions (skilled nursing facility [SNF], inpatient rehabilitation facility [IRF], and Home Health Care [HHC]) across various racial groups. Multinomial logistic regression examined the association between race and post-acute discharge dispositions after accounting for patient-level covariates. Compared to non-Hispanic Whites, minority racial groups have significantly lower odds of being discharged to SNF, IRF, or HHC, as compared to home. Adjusted odds ratio for Hispanics discharged to SNF was 0.28 (CI=0.24-0.31), to IRF was 0.46 (CI=0.39-0.52) and HHC was 0.64 (95% CI =0.54-0.75), as compared to home. CONCLUSION: ADRD patients have higher risk of hip fracture. Findings from this study will provide insight on how to reduce racial and ethnic disparities in post-acute care utilization in vulnerable populations.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The incidence of hip fracture in patients with Alzheimer’s disease and related dementias (ADRD) is 2.7 times higher than it is in those without ADRD. Care complexity, including extensive post-acute rehabilitation, increases substantially in patients with ADRD after hip fracture. However, there are no standardized post-acute care utilization models for patients with ADRD after hip fracture. Additionally, there is a lack of knowledge on how post-acute utilization varies by race/ethnicity, in this population. To investigate racial differences in post-acute care utilization following hip fracture related hospitalization in patients with ADRD. A secondary analysis was conducted on 120,179 older adults with ADRD with incident hip fracture, using 100% Medicare data (2016-2017). The primary outcome was post-acute discharge dispositions (skilled nursing facility [SNF], inpatient rehabilitation facility [IRF], and Home Health Care [HHC]) across various racial groups. Multinomial logistic regression examined the association between race and post-acute discharge dispositions after accounting for patient-level covariates. Compared to non-Hispanic Whites, minority racial groups have significantly lower odds of being discharged to SNF, IRF, or HHC, as compared to home. Adjusted odds ratio for Hispanics discharged to SNF was 0.28 (CI=0.24-0.31), to IRF was 0.46 (CI=0.39-0.52) and HHC was 0.64 (95% CI =0.54-0.75), as compared to home. CONCLUSION: ADRD patients have higher risk of hip fracture. Findings from this study will provide insight on how to reduce racial and ethnic disparities in post-acute care utilization in vulnerable populations. |
Eaves, Emery R; Camplain, Ricky L; Lininger, Monica R; Trotter, Robert T Adverse childhood experiences in relation to drug and alcohol use in 30 days prior to incarceration in a county jail Journal Article International Journal of Prisoner Health, 2020. @article{Eaves2020, title = {Adverse childhood experiences in relation to drug and alcohol use in 30 days prior to incarceration in a county jail}, author = {Emery R. Eaves and Ricky L. Camplain and Monica R. Lininger and Robert T. Trotter}, url = {https://doi.org/10.1108/IJPH-06-2020-0038}, doi = {10.1108/IJPH-06-2020-0038}, year = {2020}, date = {2020-11-16}, journal = {International Journal of Prisoner Health}, abstract = {Purpose: The purpose of this paper is to characterize the relationship between adverse childhood experiences (ACEs) and substance use among people incarcerated in a county jail. Design/methodology/approach: A questionnaire was administered to 199 individuals incarcerated in a Southwest county jail as part of a social-epidemiological exploration of converging comorbidities in incarcerated populations. Among 96 participants with complete ACEs data, the authors determined associations between individual ACEs items and a summative score with methamphetamine (meth), heroin, other opiates and cocaine use and binge drinking in the 30 days prior to incarceration using logistic regression. Findings: People who self-reported use of methamphetamine, heroin, other opiates or cocaine in the 30 days prior to incarceration had higher average ACEs scores. Methamphetamine use was significantly associated with living with anyone who served time in a correctional facility and with someone trying to make them touch sexually. Opiate use was significantly associated with living with anyone who was depressed, mentally ill or suicidal; living with anyone who used illegal street drugs or misused prescription medications; and if an adult touched them sexually. Binge drinking was significantly associated with having lived with someone who was a problem drinker or alcoholic. Social implications: The findings point to a need for research to understand differences between methamphetamine use and opiate use in relation to particular adverse experiences during childhood and a need for tailored intervention for people incarcerated in jail. Originality/value: Significant associations between methamphetamine use and opiate use and specific ACEs suggest important entry points for improving jail and community programming.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Purpose: The purpose of this paper is to characterize the relationship between adverse childhood experiences (ACEs) and substance use among people incarcerated in a county jail. Design/methodology/approach: A questionnaire was administered to 199 individuals incarcerated in a Southwest county jail as part of a social-epidemiological exploration of converging comorbidities in incarcerated populations. Among 96 participants with complete ACEs data, the authors determined associations between individual ACEs items and a summative score with methamphetamine (meth), heroin, other opiates and cocaine use and binge drinking in the 30 days prior to incarceration using logistic regression. Findings: People who self-reported use of methamphetamine, heroin, other opiates or cocaine in the 30 days prior to incarceration had higher average ACEs scores. Methamphetamine use was significantly associated with living with anyone who served time in a correctional facility and with someone trying to make them touch sexually. Opiate use was significantly associated with living with anyone who was depressed, mentally ill or suicidal; living with anyone who used illegal street drugs or misused prescription medications; and if an adult touched them sexually. Binge drinking was significantly associated with having lived with someone who was a problem drinker or alcoholic. Social implications: The findings point to a need for research to understand differences between methamphetamine use and opiate use in relation to particular adverse experiences during childhood and a need for tailored intervention for people incarcerated in jail. Originality/value: Significant associations between methamphetamine use and opiate use and specific ACEs suggest important entry points for improving jail and community programming. |
Sy, Angela; Hayes, Traci; Laurila, Kelly; Noboa, Carlamarie; Langwerden, Robbert J; Hospital, Michelle M; Andújar-Pérez, Doris A; Stevenson, Lakesha; Cunningham, Suzanne Randolph M; Rollins, Latrice; Madanat, Hala; Penn, Tanya; Mehravaran, Shiva Evaluating Research Centers in Minority Institutions: Framework, Metrics, Best Practices, and Challenges Journal Article International Journal of Environmental Research and Public Health, 17 (22), 2020. @article{Sy2020, title = {Evaluating Research Centers in Minority Institutions: Framework, Metrics, Best Practices, and Challenges}, author = {Angela Sy and Traci Hayes and Kelly Laurila and Carlamarie Noboa and Robbert J Langwerden and Michelle M Hospital and Doris A Andújar-Pérez and Lakesha Stevenson and Suzanne M Randolph Cunningham and Latrice Rollins and Hala Madanat and Tanya Penn and Shiva Mehravaran}, url = {https://www.mdpi.com/1660-4601/17/22/8373}, doi = {10.3390/ijerph17228373}, year = {2020}, date = {2020-11-12}, journal = {International Journal of Environmental Research and Public Health}, volume = {17}, number = {22}, abstract = {The NIH-funded Research Centers in Minority Institutions (RCMI) program is currently funding 18 academic institutions to strengthen the research environment and contribution to health disparities research. The purpose of this multiphase mixed-methods study was to establish a uniform evaluation framework for demonstrating the collective success of this research consortium. Methods included discussions of aims and logic models at the RCMI Evaluators' Workshop, a literature review to inform an evaluation conceptual framework, and a case study survey to obtain evaluation-related information and metrics. Ten RCMIs participated in the workshop and 14 submitted responses to the survey. The resultant RCMI Evaluation Conceptual Model presents a practical ongoing approach to document RCMIs' impacts on health disparities. Survey results identified 37 common metrics under four primary categories. Evaluation challenges were issues related to limited human resources, data collection, decision-making, defining metrics, cost-sharing, and revenue-generation. There is a need for further collaborative efforts across RCMI sites to engage program leadership and community stakeholders in addressing the identified evaluation challenges and measurement. Program leadership should be engaged to apply the Evaluation Conceptual Framework and common metrics to allow for valid inter-institutional comparisons and consortium-wide evaluations. Stakeholders could ensure evaluation metrics are used to facilitate community impacts.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The NIH-funded Research Centers in Minority Institutions (RCMI) program is currently funding 18 academic institutions to strengthen the research environment and contribution to health disparities research. The purpose of this multiphase mixed-methods study was to establish a uniform evaluation framework for demonstrating the collective success of this research consortium. Methods included discussions of aims and logic models at the RCMI Evaluators' Workshop, a literature review to inform an evaluation conceptual framework, and a case study survey to obtain evaluation-related information and metrics. Ten RCMIs participated in the workshop and 14 submitted responses to the survey. The resultant RCMI Evaluation Conceptual Model presents a practical ongoing approach to document RCMIs' impacts on health disparities. Survey results identified 37 common metrics under four primary categories. Evaluation challenges were issues related to limited human resources, data collection, decision-making, defining metrics, cost-sharing, and revenue-generation. There is a need for further collaborative efforts across RCMI sites to engage program leadership and community stakeholders in addressing the identified evaluation challenges and measurement. Program leadership should be engaged to apply the Evaluation Conceptual Framework and common metrics to allow for valid inter-institutional comparisons and consortium-wide evaluations. Stakeholders could ensure evaluation metrics are used to facilitate community impacts. |
Canori, Alexandra; Kumar, Amit; Hiremath, Shivayogi V Factors associated with multiple hospital readmissions for individuals with spinal cord injury Journal Article CommonHealth, 1 (2), 2020. @article{Canori2020, title = {Factors associated with multiple hospital readmissions for individuals with spinal cord injury}, author = {Alexandra Canori and Amit Kumar and Shivayogi V Hiremath }, url = {https://tuljournals.temple.edu/index.php/commonhealth/article/view/399 }, doi = {10.15367/ch.v1i2.399}, year = {2020}, date = {2020-09-28}, journal = {CommonHealth}, volume = {1}, number = {2}, abstract = {The study purpose was to identify patient-level and clinical factors associated with multiple hospital readmissions in individuals with spinal cord injury (SCI). Of the 1170 participants included in the study, 228 were readmitted once and 120 were readmitted multiple times. In our study, 34.2% and 10.8% were readmitted more than once due to genitourinary and respiratory conditions, respectively. Lower utilization of rehabilitation services, lower functional status, unemployment, and depression were associated with higher odds of being readmitted multiple times within one year of discharge from inpatient rehabilitation facility. }, keywords = {}, pubstate = {published}, tppubtype = {article} } The study purpose was to identify patient-level and clinical factors associated with multiple hospital readmissions in individuals with spinal cord injury (SCI). Of the 1170 participants included in the study, 228 were readmitted once and 120 were readmitted multiple times. In our study, 34.2% and 10.8% were readmitted more than once due to genitourinary and respiratory conditions, respectively. Lower utilization of rehabilitation services, lower functional status, unemployment, and depression were associated with higher odds of being readmitted multiple times within one year of discharge from inpatient rehabilitation facility. |
Barger, Steven D; Lininger, Monica R; II, Robert Trotter T; Wayment, Heidi A; Mbegbu, Mimi; Kyman, Shari; Pearson, Talima Educational Attainment and Staphylococcus aureus Colonization in a Hispanic Border Community: Testing Fundamental Cause Theory Journal Article mSphere, 5 (5), 2020. @article{Barger2020b, title = {Educational Attainment and Staphylococcus aureus Colonization in a Hispanic Border Community: Testing Fundamental Cause Theory}, author = {Steven D Barger and Monica R Lininger and Robert T Trotter II and Heidi A Wayment and Mimi Mbegbu and Shari Kyman and Talima Pearson}, year = {2020}, date = {2020-09-20}, journal = {mSphere}, volume = {5}, number = {5}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Williamson, Heather J; McCarthy, Michael J; Garcia, Yolanda E; Bacon, Rachel; Dunn, Dorothy J; Baldwin, Julie A Public Policy & Aging Report, 20 (20), pp. 1–3, 2020. @article{Williamson2020b, title = {Addressing the Needs of Rural Caregivers of Individuals with Alzheimer’s Disease and Related Dementias During and Beyond Coronavirus Disease 2019 (COVID-19)}, author = {Heather J. Williamson and Michael J. McCarthy and Yolanda E. Garcia and Rachel Bacon and Dorothy J. Dunn and Julie A. Baldwin}, url = {https://doi.org/10.1093/ppar/praa024}, doi = {10.1093/ppar/praa024}, year = {2020}, date = {2020-09-04}, journal = {Public Policy & Aging Report}, volume = {20}, number = {20}, pages = {1–3}, abstract = {More than 25% of those 65 years or older in the United States reside in rural areas (Skoufalos et al., 2017). Aging family caregivers of individuals with Alzheimer’s disease and related dementias (ADRD) provide critical daily supports for their loved one. Caregivers in rural areas face unique challenges in accessing needed health and social services, while also having limited informal supports from family and friends due to geographic isolation (Cho et al., 2016; Greenwood et al., 2015; Pinquart & Sörensen, 2005). Rural-residing ADRD caregivers living in northern Arizona have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic, with higher rates of COVID-19 than urban areas and with limited community resources (Arizona Department of Health Services, 2020; Kaplan, 2020; Sanderson et al., 2017). OVID-19 public health actions, including social distancing, self isolation, and sheltering in place, may be effective for curbing the spread of COVID-19. However, the emotional and psychosocial impacts of these prevention efforts are yet to be understood among already strained aging caregivers providing constant care for a person with ADRD.}, keywords = {}, pubstate = {published}, tppubtype = {article} } More than 25% of those 65 years or older in the United States reside in rural areas (Skoufalos et al., 2017). Aging family caregivers of individuals with Alzheimer’s disease and related dementias (ADRD) provide critical daily supports for their loved one. Caregivers in rural areas face unique challenges in accessing needed health and social services, while also having limited informal supports from family and friends due to geographic isolation (Cho et al., 2016; Greenwood et al., 2015; Pinquart & Sörensen, 2005). Rural-residing ADRD caregivers living in northern Arizona have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic, with higher rates of COVID-19 than urban areas and with limited community resources (Arizona Department of Health Services, 2020; Kaplan, 2020; Sanderson et al., 2017). OVID-19 public health actions, including social distancing, self isolation, and sheltering in place, may be effective for curbing the spread of COVID-19. However, the emotional and psychosocial impacts of these prevention efforts are yet to be understood among already strained aging caregivers providing constant care for a person with ADRD. |
Yazzie, Del; Tallis, Kristen; Curley, Caleigh; Sanderson, Priscilla R; Eddie, Regina; Behrens, Timothy K; Antone-Nez, Ramona; Ashley, Martin; Benally, Herbert John; Begay, Gloria Ann; Jumbo-Rintila, Shirleen; de Heer, Hendrik D The Navajo Nation Healthy Diné Nation Act: A Two Percent Tax on Foods of Minimal-to-No Nutritious Value, 2015–2019 Preventing Chronic Disease Journal Article Preventing Chronic Disease, 17 , 2020. @article{Yazzie2020, title = {The Navajo Nation Healthy Diné Nation Act: A Two Percent Tax on Foods of Minimal-to-No Nutritious Value, 2015–2019 Preventing Chronic Disease}, author = {Del Yazzie and Kristen Tallis and Caleigh Curley and Priscilla R. Sanderson and Regina Eddie and Timothy K. Behrens and Ramona Antone-Nez and Martin Ashley and Herbert John Benally and Gloria Ann Begay and Shirleen Jumbo-Rintila and Hendrik D. de Heer}, url = {https://www.cdc.gov/pcd/issues/2020/pdf/20_0038.pdf}, year = {2020}, date = {2020-09-03}, journal = {Preventing Chronic Disease}, volume = {17}, abstract = {Our study summarizes tax revenue and disbursements from the Navajo Nation Healthy Diné Nation Act of 2014, which included a 2% tax on foods of minimal-to-no nutritional value (junk food tax), the first in the United States and in any sovereign tribal nation. Since the tax was implemented in 2015, its gross revenue has been $7.58 million, including $1,887,323 in 2016, the first full year. Revenue decreased in absolute value by 3.2% in 2017, 1.2% in 2018, and 4.6% in 2019, a significant downward trend (P = .02). Revenue allocated for wellness projects averaged $13,171 annually for each local community, with over 99% successfully disbursed and more rural areas generating significantly less revenue. Our results provide context on expected revenue, decreases over time, and feasibility for tribal and rural communities considering similar policies.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Our study summarizes tax revenue and disbursements from the Navajo Nation Healthy Diné Nation Act of 2014, which included a 2% tax on foods of minimal-to-no nutritional value (junk food tax), the first in the United States and in any sovereign tribal nation. Since the tax was implemented in 2015, its gross revenue has been $7.58 million, including $1,887,323 in 2016, the first full year. Revenue decreased in absolute value by 3.2% in 2017, 1.2% in 2018, and 4.6% in 2019, a significant downward trend (P = .02). Revenue allocated for wellness projects averaged $13,171 annually for each local community, with over 99% successfully disbursed and more rural areas generating significantly less revenue. Our results provide context on expected revenue, decreases over time, and feasibility for tribal and rural communities considering similar policies. |
Pro, George; Hubach, Randolph; Wheeler, Denna; Camplain, Ricky; Haberstroh, Shane; Giano, Zachary; Camplain, Carolyn; Baldwin, Julie A Differences in US COVID-19 case rates and case fatality rates across the urban-rural continuum Journal Article Rural Remote Health, 20 (3), 2020. @article{Pro2020b, title = {Differences in US COVID-19 case rates and case fatality rates across the urban-rural continuum}, author = {George Pro and Randolph Hubach and Denna Wheeler and Ricky Camplain and Shane Haberstroh and Zachary Giano and Carolyn Camplain and Julie A Baldwin}, url = {https://www.rrh.org.au/journal/article/6074}, doi = {10.22605/RRH6074}, year = {2020}, date = {2020-08-19}, journal = {Rural Remote Health}, volume = {20}, number = {3}, abstract = {The majority of COVID-19 public health and media messaging in the USA has focused on major outbreaks in densely populated urban areas, including New York City, New Orleans and Seattle. This attention is indeed warranted, as the number of deaths is an important indicator of outbreak severity and informs public health, medical and government responses. In addition to case rates and the number of deaths, the case fatality rate is another epidemiologic tool used in disease surveillance and is helpful in illuminating disparities between urban and rural populations. Case fatality rates account for the number of deaths (numerator) and the number of reported cases (denominator), allowing for direct comparisons of the mortality burden of a disease between areas where the reported case rates may differ.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The majority of COVID-19 public health and media messaging in the USA has focused on major outbreaks in densely populated urban areas, including New York City, New Orleans and Seattle. This attention is indeed warranted, as the number of deaths is an important indicator of outbreak severity and informs public health, medical and government responses. In addition to case rates and the number of deaths, the case fatality rate is another epidemiologic tool used in disease surveillance and is helpful in illuminating disparities between urban and rural populations. Case fatality rates account for the number of deaths (numerator) and the number of reported cases (denominator), allowing for direct comparisons of the mortality burden of a disease between areas where the reported case rates may differ. |