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Molecular structure and liquids used in research labs
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  6. Raman Methods to Facilitate Single Molecule Detection of Biological Threats

Raman Methods to Facilitate Single Molecule Detection of Biological Threats

Description

Raman spectroscopy can generate specific signatures that can be used to rapidly detect biothreat agents, providing information that can prevent a successful attack against the US and its interests. It is fast, inexpensive, and can be deployed in the field; however, its widespread utility is hampered by several problems.

This technology focuses on the improved detection of biothreats using Surface Enhanced Raman (SER) spectroscopy and specific substrates for highly sensitive detection.

Additional information

Patent number and inventor

Patent pending

David Wagner, Miguel José Yacamán, and Paul Keim.

Potential applications

The primary application is the detection of biological threats such as Bacillus anthracis.

Benefits and advantages

This technology directly addresses and overcomes the two most significant problems associated with the current Raman spectroscopy approach used for the detection of biological agents in aerosols: 1) a weak, low-intensity signal that, therefore, requires a significant number of target molecules to be present to facilitate detection, and 2) the fluorescence effect in biomolecules that introduces noise on the Raman spectra.

Case number and licensing status

2020-040

This invention is available for licensing.