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  6. Lattice Light-Sheet and Fresnel Incoherent Correlation Holography

Lattice Light-Sheet and Fresnel Incoherent Correlation Holography

Description

Light sheet microscopy is a high-speed, low-excitation intensity, 3D imaging technique. While light sheet microscopy provides advantages over other known microscopy techniques, excitation light sheets disperse rapidly in refractive tissue which limits the penetration depth of a target or sample material. Lattice light-sheet microscopy uses a convergent lattice of Bessel beams to generate the light sheet but is still limited to an imaging depth of approximately 100 μm in live tissue due to optical distortions. This system and method are designed to perform incoherent holographic microscopy imaging to generate a 3D image of a sample.

Additional Information

Patent number and inventors

PCT/US2021/17102

Christopher Mann

Potential applications

Analytical applications

Benefits and advantages

This system utilizes a modified dual-lens Fresnel incoherent correlation holography technique to produce a complex hologram and to provide a reconstruction distance needed for the reconstruction of the hologram. Additionally, this system enables the generation of 3D holographic images without requiring the movement of any of a sample stage or detection microscope objective which simplifies the system setup and reduces the need for mechanical components and controls.

Case number and licensing status

2021-030

This invention is available for licensing.