Office: Building 88, Room 237
- cancer systems biology
- Professor, Clinical Translational Research Division, Translational Genomics Research Institute, Phoenix, AZ 2006-present
- Visiting Professor, Ludwig Institute for Cancer Research 2007-2008
- Fogarty Center Senior International Fellow, Weizmann Institute of Science, 1999-2000
- Los Alamos National Laboratory, 1990-1993
- PhD, MS: Cornell University, Biophysical Chemistry, 1990
- BA: SUNY Binghamton, Chemistry, 1980
Our research efforts are directed at developing experimental and mathematical tools for elucidating the molecular details of cell signaling pathways.
Cancer pathways are complex dynamical systems that cannot be fully and deeply understood through intuition alone, and predictive mathematical models, which have been successfully used to understand and manipulate complex technological and physical systems, are simply unavailable to help us understand these systems. We aim to fill this void by translating our biochemical mechanistic knowledge of cancer pathways into the logic circuits that underpin cancer.
Whatcott, CJ, Han, H, Posner RG, Hostetter G, and Von Hoff, DD. Targeting the Tumor Microenvironment in Cancer: Why Hyaluronidase Deserves a Second Look Cancer Discovery September 2011;1:291-296
Chylek LA, Hu B, Blinov ML, Emonet T, Faeder JR, Goldstein B, Gutenkunst RN, Haugh JM, Lipniacki T, Posner RG, Yang J, Hlavacek WS Guidelines for visualizing and annotating rule-based models.. Mol Biosyst. 2011 Jun 7.
Colvin J, Monine MI, Faeder JR, Hlavacek WS, Von Hoff DD, Posner RG. “Simulation of large-scale rule-based models,” Bioinformatics. 2009 Apr 1;25(7):910-7.
Colvin J, Monine MI, Gutenkunst RN, Hlavacek WS, Von Hoff DD, Posner RG. RuleMonkey: software for stochastic simulation of rule-based models. BMC Bioinformatics 2010; 11:404
Monine MI, Posner RG, Savage PB, Faeder JR, Hlavacek WS. Modeling Multivalent Ligand- Receptor Interactions with Steric Constraints on Configurations of Cell-Surface Receptor Aggregates. Biophys J. 2010 Jan 6;98(1):48-56.
Hu B, Fricke MG, Faeder JR, Posner RG, Hlavacek WS, “GetBonNie for building, analyzing and sharing rule-based models.” Bioinformatics. 2009 Jun 1;25(11):1457-60.