Paul Keim  

 

Regents' Professor and Cowden Chair
Phone: 928-523-1078
Email: Paul.Keim@nau.edu
Office: bldg. 56 room 316

Research/teaching interests

Genetic analysis of diverse organisms including:

• bacteria
• fungi
• bird
• plants
• animals

Academic highlights

• Faculty: Northern Arizona University, 1989
• Postdoctoral Fellow: Iowa State University, 1987-1988
• Postdoctoral Fellow/Research Assistant Professor: University of Utah, 1981-1987
• PhD: University of Kansas, Plant Biochemistry, 1981
• BS: Northern Arizona University, Biology and Chemistry, 1977

Dr. Keim works on the molecular genetic analysis of diverse organisms including bacteria, fungi, birds, plants and animals. This primarily focused on defining population structure or addressing systematic issue. In a few cases, this approach has been used in forensic investigations of criminal acts.

Selected publications

Pearson, Talima, Joseph Busch, Jacques Ravel, Tim Read, Shane Rhoton, Jana U’Ren, Tatum Simonson, Sergey Kachur, Rebecca Leadem, Michelle Cardon, Matthew VanErt, Lynn Huynh, Claire Fraser and Paul Keim. Phylogenetic discovery bias in Bacillus anthracis using single nucleotide polymorphisms from whole genome sequencing. In press. Proceedings of the National Academy of Sciences (USA).

Johansson*, Anders, Jason Farlow*, Pär Larsson, Meghan Dukarich, Elias Chambers, Mona Byström, James Fox, May Chu, Mats Forsman, Anders Sjöstedt, And Paul Keim. 2004. World-Wide Genetic Relationships Among Francisella tularensis Isolates Using Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA). J. Bacteriology 186:5808-5818.

Girard*, Jessica M., David M. Wagner*, Amy J. Vogler, Christine Keys, Christopher J. Allender, Lee C. Drickamer, Paul Keim. 2004. Plague Population Genetic Structure is Determined by Transmission Dynamics. Proceedings of the National Academy of Sciences (USA). 101:8409-8413. (cover photo).

Keim, Paul, Matthew Van Ert, Talima Pearson, Amy Vogler, Lynn Hyunh, and David Wagner. 2004. Anthrax Molecular Epidemiology and Forensics: Using Different Markers for the Appropriate Evolutionary Scales. Infection, Genetics and Evolution 4:205-213.

Read, TD, S.L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E. Holtzapple, J. Busch, K.L. Smith, J.M. Schupp, D. Solomon, P. Keim, C.M. Fraser. 2002. Comparative Genome Sequencing for Discovery of Novel Polymorphisms in Bacillus anthracis. Science. 296:2028-2033.

Erin P. Price, Meagan L. Seymour, Derek S. Sarovich,1 Jennie Latham, Spenser R. Wolken, Joanne Mason, Gemma Vincent, Kevin P. Drees, Stephen M. Beckstrom-Sternberg, Adam M. Phillippy, Sergey Koren, Richard T. Okinaka, Wai-Kwan Chung, James M. Schupp, David M. Wagner, Richard Vipond, Jeffrey T. Foster, Nicholas H. Bergman, James Burans, Talima Pearson, Tim Brooks, and Paul Keim. 2012. Molecular Epidemiologic Investigation of an Anthrax Outbreak among Heroin Users, Europe. Emerg Infect Dis. 18(8): 1307–1313. doi:  10.3201/eid1808.111343. PMCID: PMC3414016

Kenneth I. Berns,  Arturo Casadevall,  Murray L. Cohen, Susan A. Ehrlich,  Lynn W. Enquist, J. Patrick Fitch,  David R. Franz,  Claire M. Fraser-Liggett,  Christine M. Grant,       Michael J. Imperiale,  Joseph Kanabrocki,  Paul S. Keim,  Stanley M. Lemon, Stuart B. Levy,  John R. Lumpkin, Jeffery F. Miller,  Randall Murch,  Mark E. Nance,  Michael T. Osterholm,  David A. Relman,  James A. Roth & Anne K. Vidaver. 2012. Policy: Adaptations of avian flu virus are a cause for concern. Nature 482, 153–154 (09 February 2012) doi:10.1038/482153a

Rene S. Hendriksen, Lance B. Price, James M. Schupp, John D. Gillece, Rolf S. Kaas, David M. Engelthaler, Valeria Bortolaia, Talima Pearson, Andrew E. Waters, Bishnu Prasad Upadhyay, Sirjana Devi Shrestha, Shailaja Adhikari, Geeta Shakya, Paul S. Keim, and Frank M. Aarestrup. 2011. Population genetics of Vibrio cholerae from Nepal in 2010: Evidence on the Origin of the Haitian Outbreak. mBio 2(4):e00157-11. doi:10.1128/mBio.00157-11.

Lance B. Price, Marc Steggeb, Henrik Hasman, Maliha Aziz, Jesper Larsen, Paal Skytt Andersen, Talima Pearson, Andrew E. Waters, Jeffrey T. Foster, James Schupp, John Gillece, Elizabeth Driebe, Cindy M. Liu, Burkhard Springer, Irena Zdovc, Antonio Battisti, Alessia Franco, Jacek Żmudzki, Stefan Schwarz, Patrick Butaye, Eric Jouy, Constanca Pomba, M. Concepción Porrero, Raymond Ruimyo Tara C. Smith, D. Ashley Robinson, J. Scott Weese, Carmen Sofia Arriola, Fangyou Yu, Frederic Laurent, Paul Keim, Robert Skov, and Frank M. Aarestrup. 2012. Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock. mBio 3(1):e00305-11. doi:10.1128/mBio.00305-11.